In the Journals

Patients with CKD, diabetes mellitus at no greater cardiorenal risk than patients without diabetes

Patients with non-proteinuric diabetes mellitus and chronic kidney disease are not at greater risk for cardiorenal syndrome compared to patients with CKD and no diabetes, according to a study published in Nephrology Dialysis Transplantation. The presence of diabetes per se, as well as moderate proteinuria, was associated with a higher mortality and cardiovascular event risk; but abnormal proteinuria effected the risk of ESRD independent of diabetes.

“In the absence of proteinuria, [diabetes mellitus with chronic kidney disease] DM-CKD patients are not exposed to increased cardiorenal risk when compared with non-diabetic CKD patients,” Roberto Minutolo, MD, PhD, of the division of nephrology at the University of Campania in Italy, and colleagues wrote. “In contrast, in proteinuric CKD patients, the risk of ESRD is primarily driven by the proteinuria level independent of diabetic status. The independent effect of diabetic status per se only emerges in the presence of moderate proteinuria where diabetes heralds a higher risk of [cardiovascular] CV morbidity and mortality.”

Researchers used data gathered from four similar cohort studies that used patient information from 40 Italian nephrology clinics. Each cohort study gathered patient CV disease history; physical exam data on height, body weight and medication profiles; and lab results. Researchers looked at outcome measures including all-cause death, ESRD, the composite CV endpoint of non-fatal CV events requiring hospitalization and CV death, whichever occurred first, according to the report.

Furthermore, researchers noted that the study had only been limited by its predictors at baseline. However, it was determined that follow-ups after patients’ initial visit to the clinic could exclude any substantial changes in their risk factors that would impact study outcomes. - by Scott Buzby

Disclosure: Minutolo reports no relevant financial disclosures.

For more information: Minutolo can be reached at roberto.minutolo@unicampania.it.

Patients with non-proteinuric diabetes mellitus and chronic kidney disease are not at greater risk for cardiorenal syndrome compared to patients with CKD and no diabetes, according to a study published in Nephrology Dialysis Transplantation. The presence of diabetes per se, as well as moderate proteinuria, was associated with a higher mortality and cardiovascular event risk; but abnormal proteinuria effected the risk of ESRD independent of diabetes.

“In the absence of proteinuria, [diabetes mellitus with chronic kidney disease] DM-CKD patients are not exposed to increased cardiorenal risk when compared with non-diabetic CKD patients,” Roberto Minutolo, MD, PhD, of the division of nephrology at the University of Campania in Italy, and colleagues wrote. “In contrast, in proteinuric CKD patients, the risk of ESRD is primarily driven by the proteinuria level independent of diabetic status. The independent effect of diabetic status per se only emerges in the presence of moderate proteinuria where diabetes heralds a higher risk of [cardiovascular] CV morbidity and mortality.”

Researchers used data gathered from four similar cohort studies that used patient information from 40 Italian nephrology clinics. Each cohort study gathered patient CV disease history; physical exam data on height, body weight and medication profiles; and lab results. Researchers looked at outcome measures including all-cause death, ESRD, the composite CV endpoint of non-fatal CV events requiring hospitalization and CV death, whichever occurred first, according to the report.

Furthermore, researchers noted that the study had only been limited by its predictors at baseline. However, it was determined that follow-ups after patients’ initial visit to the clinic could exclude any substantial changes in their risk factors that would impact study outcomes. - by Scott Buzby

Disclosure: Minutolo reports no relevant financial disclosures.

For more information: Minutolo can be reached at roberto.minutolo@unicampania.it.