Bone and Mineral Metabolism Disorders
PHILADELPHIA — Concomitant use of the potassium binder patiromer enabled more patients with resistant hypertension and advanced chronic kidney disease to continue treatment with spironolactone, with less hyperkalemia, according to new data from the AMBER trial presented at the Heart Failure Society of America Scientific Meeting.
In the phase 2, randomized, double-blind, placebo-controlled trial, 295 patients with resistant hypertension and advanced CKD were randomly assigned receive placebo or patiromer 8.4 g once daily (Veltassa, Relypsa) in addition to open-label spironolactone, started at 25 mg once daily, and baseline BP medications.
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This activity is supported by an educational grant from Ultragenyx.
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