In a population-based cohort, each 1 µU/mL increase in fasting insulin level was associated with an average half-pound increase in body weight over 10 years, whereas each unit increase in insulin resistance was associated with an average 1.32-pound increase in body weight over the same period, according to findings published in Diabetes Metabolism Research and Reviews.
“Past reports have shown mixed results on the role of endogenous insulin levels in weight gain,” Nicholas Pennings, DO, assistant professor and chair of family medicine at Campbell University School of Osteopathic Medicine in Buies Creek, North Carolina, told Endocrine Today. “This study examined the relationship between fasting insulin levels and weight gain and identified that weight occurred as insulin levels began to rise, triggering weight gain before glucose rose to abnormal levels. The impact of rising insulin levels is seen at fairly low fasting insulin levels and diminishes at higher levels where insulin resistance is more significant.”
This activity is supported by an educational grant from Novo Nordisk, Inc.
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