Among white men, serum estradiol exerts a “robust causal effect” on fracture risk, independent of age, BMI, smoking status and physical activity level, according to findings from a large Mendelian randomization analysis.
In an analysis of genome-wide association study data from men participating in the UK Biobank, the researchers also found no causal link between testosterone levels and estimated bone mineral density, a predictor of fracture risk.
This activity is supported by an educational grant from Portola Pharmaceuticals, Inc.
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