BOSTON — The pipeline for new therapies to treat drug-resistant
gram-negative bacilli is small, but measurable progress is being made,
according to Helen Boucher, MD, who presented results on the progress of
IDSA's "10 x '20 initiative." She and colleagues identified nine intravenous
compounds in development to treat these resistant bacteria.
Since a previous survey was conducted in 2009, only two new antibiotics
have been approved, and only one of the hoped for
10 x '20 drugs has been approved, Boucher, who is
assistant professor of medicine at Tufts University School of Medicine, said
during a press conference today. In addition, the number of large
pharmaceutical companies that are actively developing antibiotics continues to
To quantify the severity of this problem, Boucher and colleagues
conducted a review of literature, clinical trial registries and interviews with
pharmaceutical leaders to gain information on the pipeline of novel
antimicrobial therapies to treat drug-resistant gram-negative bacilli.
They found nine IV compounds in clinical development, including one
beta-lactamase inhibitor in a phase 3 trial and six
compounds (an aminoglycoside, a beta-lactamase inhibitor, a tRNA synthetase
inhibitor, a peptide mimetic and a fluorocycline) in phase 2 studies of acute
bacterial skin and skin structure infections, complicated urinary tract
infection and/or complicated intra-abdominal infections. Two agents - a
siderophore monosulfactam and a beta-lactamase inhibitor - are currently in
phase 1 or preclinical development, the researchers reported.
There were no studies of hospital-acquired bacterial pneumonia or
ventilator-associated bacterial pneumonia, and only three compounds had a novel
mechanism of action, according to the abstract.
Boucher said the decline in the number of large pharmaceutical companies
investing in the development of antibiotics - "the loss of the brain trust" -
has tremendous consequences that may take years to overcome. — by Stacey L.
For more information:
- Boucher H. LB-27. Presented at: IDSA 49th Annual Meeting; Oct.
20-23, 2011; Boston.
Disclosure: Dr. Boucher is on the adjudication committee and
receives a consulting fee from Merck; is a Data and Safety Monitoring Board
member and receives a consulting fee from Wyeth/Pfizer; is a consultant and
receives fees from Durata Therapeutics; and is a consultant and receives a fee