EXPERT SUMMARIES of the top 30 journals in infectious disease
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Universal MenB vaccination of college-aged adults not cost-effective

Leeds IL, et al. Am J Prev Med. 2018; doi:10.1016/j.amepre.2018.09.020 .
Universally vaccinating young adults entering college with the meningococcal B vaccine is not cost-effective because of the rarity of…
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HIV-infected Hispanics at greater risk for HPV-related cancers

Ortiz A, et al. Cancer. 2018;doi:10.1002/cncr.31702.
HIV-infected Hispanic adults in the United States demonstrated a higher risk for HPV-related cancers than Hispanics who did not have HIV, according…
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Depleted plasma gelsolin linked to severe pneumonia outcomes

Self WH, et al. Clin Infect Dis. 2018;doi:10.1093/cid/ciy1049.
Researchers found that a lower concentration of plasma gelsolin, or pGSN, was associated with more severe clinical outcomes in adults hospitalized…
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Meningococcal B vaccine Bexsero may protect against gonorrhea

Semchenko EA, et al. Clin Infect Dis. 2018;doi:10.1093/cid/ciy1061.
Bexsero, a meningococcal B vaccine approved in the United States since 2015, induces antibodies in humans that target Neisseria gonorrhoeae
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Study: Probiotics do not reduce C. difficile in hospitalized patients

Box MJ et al. Open Forum Infect Dis. 2018;
A large retrospective cohort study showed that probiotics did not decrease rates of facility-onset Clostridioides difficile in hospitalized patients…
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Schistosomiasis associated with HIV transmission, death

Wall KM, et al. PLoS Negl Trop Dis. 2018;doi:10.1371/journal.pntd.0006902.
Researchers found that schistosome infection was associated with increased transmission of HIV from both men and women in Zambia, as well as HIV…
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Morocco sees 16% annual decline in leprosy cases attributed to rifampicin

Khoudri I, et al. PLoS Negl Trop Dis. 2018;doi:10.1371/journal.pntd.0006910.
Leprosy cases in Morocco declined by 16% annually from 2012 to 2017 after the implementation of single-dose rifampicin chemoprophylaxis, researchers…
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Vaccination halves risk for flu-related hospitalization among adults

Ferdinands JM, et al. J Infect Dis. 2018;doi:10.1093/infdis/jiy723.
Vaccination halved the risk for influenza-associated hospitalization among adults during the 2015-2016 influenza season in the United States, most of…
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Community-acquired respiratory viruses a risk factor for chronic lung allograft dysfunction

Peghin M et al. Clin Infect Dis. 2018;
Community-acquired respiratory viruses causing lower respiratory tract infections are a significant independent risk factor for the development of…
In the Journals Plus

Patients with cancer have 40% higher risk for shingles

Kawai K and Yawn BP. J Infect Dis. 2018;doi:10.1093/infdis/jiy626.
Qian J, et al. J Infect Dis. 2018;doi:10.1093/infdis/jiy625.
Patients diagnosed with cancer of any kind have an approximately 40% higher risk for developing shingles than patients without cancer, researchers…
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Adenovirus causes keratoconjunctivitis outbreak at eye clinic

OYong K, et al. MMWR Morb Mortal Wkly Rep. 2018;doi:10.15585/mmwr.mm6748a4.
A 2017 outbreak of epidemic keratoconjunctivitis at an eye care clinic in Los Angeles was caused by a novel human adenovirus type, according to study…
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Treatment bundle leads to ‘dramatic improvement’ in UTI management

MacLaggen TD, et al. Infect Control Hospit Epidemiol. 2018;doi:10.1017/ice.2018.276.
A UTI management bundle implemented at a Canadian hospital resulted in a “dramatic improvement” in the management of UTIs, including…
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Higher RPR titers, recent diagnosis predict syphilis treatment response

Spagnuolo V, et al. Open Forum Infect Dis. 2018;
Higher rapid plasma reagin, or RPR, titers at diagnosis and a diagnosis made in more recent years are associated with serological treatment response…
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Despite guidelines, more than 100 ways PPE doffing process can fail

Gurses AP, et al. Infect Control Hosp Epidemiol. 2018;doi:10.1017/ice.2018.292.
Experts at Johns Hopkins Hospital identified more than 100 ways that health care workers can potentially self-contaminate while doffing personal…
In the Journals Plus

2-dose regimen of dalbavancin effectively treats osteomyelitis

Rappo U, et al. Open Forum Infect Dis. 2018;doi:10.1093/ofid/ofy331.
A two-dose regimen of dalbavancin — a long-acting lipoglycopeptide antibiotic approved for the treatment of acute bacterial skin and skin…
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