EXPERT SUMMARIES of the top 30 journals in infectious disease
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No differences in CDI-related complications between toxin-positive and NAAT-positive-only CDI

Guh AY, et al. Clin Infect Dis. 2018; doi.org/10.1093/cid/ciz009.
Toxin-positive Clostridioides difficile infection, or CDI, tended to be more severe than CDI that was detected through nucleic acid amplification…
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HAdV-7d outbreak underscores need to consider adenoviruses as cause of respiratory illness

Killerby M, et al. Open Forum Infect Dis. 2019;doi:10.1093/ofid/ofz017.
Researchers reporting on a deadly outbreak of human adenovirus type 7d, or HAdV-7d, said clinicians and public health authorities should consider…
In the Journals PlusPerspective

CP-CRE carriers infected with different genotype face sixfold greater mortality risk

Chen WK, et al. Open Forum Infect Dis. 2019;doi:10.1093/ofid/ofz006.
Researchers found that patients colonized with carbapenem-producing carbapenem-resistant Enterobacteriaceae, or CP-CRE, who are subsequently infected…
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Combination therapy 88% effective against HIV, leishmaniasis coinfection

Diro E, et al. PLoS Negl Trop Dis. 2019;doi:10.1371/journal.pntd.0006988.
Extended treatment with a combination of AmBisome plus miltefosine is 88% effective in treating patients with HIV and visceral leishmaniasis…
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Treatment de-intensification fails to reduce toxicity, maintain efficacy in HPV-positive oropharyngeal cancer

Gillison MR, et al. The Lancet 2018;doi:10.1016/S0140-6736(18)32779-X.
Mehanna H, et al. The Lancet. 2018;doi:10.1016/S0140-6736(18)32752-1.
Oosthuizen JC, et al. The Lancet. 2018;doi:10.1016/S0140-6736(18)32930-1.
Patients with advanced, HPV-positive
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Dermatologists prescribing more antibiotics following surgical visits

Barbieri JS, et al. JAMA Dermatol. 2019; doi:10.1001/jamadermatol.2018.4944.
Antibiotic prescribing by dermatologists has “substantially decreased” in recent years, mostly due to a drop in prescriptions for acne…
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Imported cases of Lassa fever often missed for days

Kofman A, et al. Emerg Infect Dis. 2019;doi:10.3201/eid2502.180836.
From 1969 to 2016, 33 cases of Lassa fever were diagnosed in travelers from West Africa to nine other countries, according to a new report…
In the Journals PlusPerspective

Shigella shows high resistance to azithromycin, ciprofloxacin

Ingle DJ, et al. Clin Infect Dis. 2019;doi:10.1093/cid/ciz005.
More than half of tested Shigella isolates obtained from men who have sex with men, or MSM, in an Australian state demonstrated resistance to…
In the Journals PlusPerspective

Study: 14% of transgender women, 3% of transgender men have HIV

Becasen JS, et al. Am J Public Health. 2018;doi:10.2105/AJPH.2018.304727.
Based on a systematic review and meta-analysis of available data, researchers calculated that around 14% of transgender women and 3% of transgender…
In the Journals Plus

26% of black MSM in PrEP trial diagnosed with STI during follow-up

Hightow-Weidman L, et al. Clin Infect Dis. 2019;doi:10.1093/cid/ciy1141.
More than 26% of black men who have sex with men, or MSM, who were enrolled in a pre-exposure prophylaxis, or PrEP, trial were diagnosed with an STI…
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42% of adults with HBV are coinfected with HDV, study finds

Patel EU, et al. Clin Infect Dis. 2018;doi:10.1093/cid/ciz001.
In the United States, 42% of adults with hepatitis B virus are coinfected with hepatitis D, suggesting a need for routine HDV testing among people…
In the Journals Plus

XDR typhoid infections in 5 US children linked to Pakistan outbreak

Chatham-Stephens K, et al. MMWR Morb Mortal Wkly Report. 2019;doi:10.15585/mmwr.mm6801a3.
Since 2016, five children in the United States have been diagnosed with extensively drug-resistant typhoid fever after traveling to or from Pakistan…
In the Journals PlusPerspective

Three risk factors associated with community-acquired ESBL UTIs

Goyal D, et al. Open Forum Infect Dis. 2018;doi:10.1093/ofid/ofy357.
Patients with indwelling urinary catheters, a history of recurrent urinary tract infections or recent antimicrobial use are at a higher risk for…
In the Journals PlusPerspective

Strategy of screening for HBV, then treating or vaccinating is cost-effective

Chahal HS, et al. Open Forum Infect Dis. 2018; doi.org/10.1093/ofid/ofy353.
An “inclusive” strategy of screening patients for hepatitis B virus infection or susceptibility and then treating or vaccinating them…
In the Journals Plus

Physicians accept 80% to 90% pathogen coverage in sepsis treatment

Cressman AM, et al. Clin Infect Dis. 2018;doi:10.1093/cid/ciy1031.
Kollef MH, Burnham JP. Clin Infect Dis. 2018;doi:10.1093/cid/ciy1035.
Physicians will accept pathogen coverage of 80% to 90% from their preferred empiric antibiotic regimen when managing patients with mild and severe…
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