EXPERT SUMMARIES of the top 30 journals in infectious disease
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Pregnant women at higher risk for flu-related hospitalization

Prasad N, et al. J Infect Dis. 2019;doi:10.1093/infdis/jiz035.
Pregnant women in any trimester, but not during the postpartum period, are at a higher risk for influenza-related hospitalization compared with…
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Risk for infective endocarditis related to injection drug use increasing

Weir MA, et al. Can Med Assoc J. 2019;doi:10.1503/cmaj.180694.
A recent study of people who inject drugs identified a “substantial and progressive” increase in their risk for infective endocarditis…
In the Journals PlusPerspective

OVIVA: Oral therapy noninferior to IV therapy for bone and joint infections

Li HK, et al. N Engl J Med. 2019;doi:10.1056/NEJMoa1710926.
Oral antibiotic therapy is noninferior to IV antibiotic therapy when used in the first 6 weeks of treatment for complex bone and joint infections…
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Investigational Ebola treatment yields positive results in phase 1 trial

Gaudinski MR, et al. Lancet. 2019;doi.org/10.1016/S0140-6736(19)30036-4.
MAb114, an investigational Ebola treatment, is safe, well tolerated, and easy to administer, according to results from an early-stage clinical trial…
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Flu vaccine 72% effective against H1N1 in Canada

Skowronski DM, et al. Euro Surveill. 2019;doi:10.2807/1560-7917.ES.2019.24.4.1900055.
In Canada, the influenza vaccine has been 72% effective this season against the predominant circulating virus, influenza A(H1N1)pdm09, offering…
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Influenza an important risk factor for aspergillosis coinfection

Huang L, et al. Clin Respir J. 2019;doi:doi.org/10.1111/crj.12995.
Patients with influenza who received steroids after ICU admission, have a white blood count greater than 10 x 109/L on ICU admission, and have…
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Alternative antibiotics do not reduce UTI-related hospitalizations, deaths in older adults

Ahmed H, et al. Open Forum Infect Dis. 2019;doi:10.1093/ofid/ofz039.
Alternative antibiotics to nitrofurantoin for treating suspected urinary tract infection in older patients were associated with lower odds of…
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Financial incentives do not boost HIV viral suppression rate

Thirumurthy H, et al. Lancet HIV. 2019;doi.org/10.1016/S2352-3018(18)30330-8.
Financial incentives had no effect on viral suppression among HIV-positive adults in Uganda, according to a recent study. Researchers said these…
In the Journals PlusPerspective

Less restrictive OPAT criteria for infective endocarditis safe, effective

Pericas JM, et al. Clin Infect Dis. 2019;doi:10.1093/cid/ciz030.
Outpatient parenteral antibiotic therapy for the treatment of infective endocarditis was found to be safe and effective, despite the use of less…
In the Journals PlusPerspective

S. stercoralis infection ‘widely prevalent’ in Bolivia

Getaz L, et al. PLoS Negl Trop Dis. 2019;doi:10.1371/journal.pntd.0007028.
Researchers discovered a wide prevalence of strongyloidiasis — a chronic intestinal infection caused by a soil-transmitted intestinal nematode…
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Study finds nearly 25% of antibiotics are unnecessarily prescribed

Chua KP, et al. BMJ. 2019;doi.org/10.1136/bmj.k5092.
In a recent study examining outpatient antibiotic prescriptions filled by privately insured patients, researchers found that of the 40% of patients…
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Only 1 in 10 patients filled ART prescription after hospital discharge

Antoniou T, et al. Open Forum Infect Dis. 2019;doi:10.1093/ofid/ofz009.
Approximately 90% of socially vulnerable patients with HIV did not fill their prescriptions for ART within 7 days of being discharged from a…
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Social intervention in Brazil increases rate of TB cure by 7.6%

Oliosi JGN, et al. Lancet Glob Health. 2019;doi:10.1016/S2214-109X(18)30478-9.
The Bolsa Familia Programme — a conditional cash transfer program in Brazil — directly affects tuberculosis treatment outcomes…
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Beta-lactam/daptomycin combo does not reduce mortality rates in patients with MSSA bacteremia

Grillo S, at al. Clin Infect Dis. 2018; doi.org/10.1093/cid/ciz018.
The combination of a beta-lactam and daptomycin did not improve outcomes in patients with methicillin-susceptible Staphylococcus aureus, or MSSA…
In the Journals Plus

No differences in CDI-related complications between toxin-positive and NAAT-positive-only CDI

Guh AY, et al. Clin Infect Dis. 2018; doi.org/10.1093/cid/ciz009.
Toxin-positive Clostridioides difficile infection, or CDI, tended to be more severe than CDI that was detected through nucleic acid amplification…
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