EXPERT SUMMARIES of the top 30 journals in infectious disease
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Eastern equine encephalitis transmitted via solid organ transplantation

Pouch SM, et al. Clin Infect Dis. 2018;doi:10.1093/cid/ciy923/5146011.
Researchers documented the first reported transmission of eastern equine encephalitis through solid organ transplantation and warned clinicians to be…
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Ceftolozane-tazobactam effectively treats MDR P. aeruginosa infections

Gallagher JC, et al. Open Forum Infect Dis. 2018;doi:10.1093/ofid/ofy280.
Ceftolozane-tazobactam effectively treats multidrug-resistant Pseudomonas aeruginosa infections, especially when initiated early on, findings from a…
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Vertical HCV transmission fundamentally different according to maternal coinfection status

Larouche A, et al. J Infect Dis. 2018; doi: 10.1093/infdis/jiy581.
Maternal neutralizing antibody responses have a role in preventing vertical transmission of hepatitis C virus, but not among women coinfected with…
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Drug-resistant UTI relapse tied to incorrect antibiotic therapy

Anesi JA, et al. Infect Control Hosp Epidemiol. 2018:doi:10.1017/ice.2018.254.
Patients with community-onset urinary tract infections caused by Enterobacteriaceae that are resistant to extended-spectrum cephalosporins are less…
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‘Reassuring’ evidence shows statin use does not impact flu vaccine effectiveness

Havers FP, et al. Clin Infect Dis. 2018;doi:10.1093/cid/ciy780/5145968.
Findings from a large observational study showed that statin use had no impact on influenza vaccine effectiveness in patients aged 45 years and…
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Prevalence of health care-associated infections falls to 3.2% in US

Magill SS, et al. N Engl J Med. 2018:doi:10.1056/NEJMoa1801550.
The prevalence of health care-associated infections in hospital patients in the United States decreased from 4% in 2011 to 3.2% in 2015, largely…
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Compensation for ID physicians ‘not a simple issue to fix’

Zahn M, et al. Clin Infect Dis. 2018;doi:10.1093/cid/ciy888.
Compensation policy changes are needed to attract more medical students and residents to the field of infectious diseases, where physicians are…
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Oral, gut decontamination does not reduce bloodstream infections in ICU

Vandenbroucke-Grauls CMJE, van der Meer JWM. JAMA. 2018;doi:10.1001/jama.2018.13764.
Wittekamp BH, et al. JAMA. 2018;doi:10.1001/jama.2018.13765.
Results of a randomized clinical trial showed that selective oral or digestive tract decontamination is not associated with reductions in…
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Fluorescent imaging probe quickly detects gram-negative bacteria in lungs

Akram AR, et al. Sci Transl Med. 2018;doi:10.1126/scitranslmed.aal0033.
Researchers developed a fluorescent imaging probe that can visualize gram-negative bacteria in human lungs in real time and reported that it was…
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Reducing unneeded central venous catheter use prevents CLABSIs

Xiong Z, et al. Infect Control Hosp Epidemiol. 2018; doi: 10.1017/ice.2018.250
A systematic literature review showed that interventions to reduce unnecessary central venous catheter use can significantly decrease the rate of…
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WHO-endorsed tests miss MDR-TB cases

Makhado NA, et al. Lancet Infect Dis. 2018;
WHO-endorsed tests did not detect a substantial number of multidrug-resistant tuberculosis, or MDR-TB, cases in South Africa that harbor a certain…
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Vaccine, nivolumab combination appears promising in recurrent HPV-related cancer

Massarelli E, et al. JAMA Oncol.2018;doi:10.1001/jamaoncol.2018.4051.
Treatment with a novel, synthetic, long-peptide HPV-16 vaccine plus nivolumab yielded promising response rates and survival outcomes among a small…
In the Journals Plus

Sunlight may kill dust-dwelling bacteria

Fahimipour AK, et al. Microbiome. 2018;doi:10.1186/s40168-018-0559-4.
Researchers found that letting sunlight in through windows can kill bacteria in dust around the same level as ultraviolet light. “Humans spend…
In the Journals Plus

Smartphone-based assay diagnoses UTIs at point of care

Barnes L, et al. EBioMedicine. 2018:doi:10.1016/jebiom.2018.09.001.
In a head-to-head comparison, researchers found that a smartphone-based assay was as good at detecting pathogens in urine specimens from sepsis…
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