EXPERT SUMMARIES of the top 30 journals in infectious disease
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1 in 5 pharmacies in Spain dispenses antibiotics without prescription

Zapata-Cachafeiro M, et al. J Antimicrob Chemother. 2018;
Approximately one in five pharmacies in Spain dispenses antibiotics without a prescription, especially when pressured by patients, according to a…
In the Journals Plus

CSF can show if central nervous system disease is infection-related

Fortuna D, et al. PLOS One. 2018;doi:10.1371/journal.pone.0205501.
Cerebrospinal fluid cytokine levels may be clinically useful in determining if central nervous system disorders are infection-related and to…
In the Journals Plus

Eastern equine encephalitis transmitted via solid organ transplantation

Pouch SM, et al. Clin Infect Dis. 2018;doi:10.1093/cid/ciy923/5146011.
Researchers documented the first reported transmission of eastern equine encephalitis through solid organ transplantation and warned clinicians to be…
In the Journals PlusPerspective

Ceftolozane-tazobactam effectively treats MDR P. aeruginosa infections

Gallagher JC, et al. Open Forum Infect Dis. 2018;doi:10.1093/ofid/ofy280.
Ceftolozane-tazobactam effectively treats multidrug-resistant Pseudomonas aeruginosa infections, especially when initiated early on, findings from a…
In the Journals Plus

Vertical HCV transmission fundamentally different according to maternal coinfection status

Larouche A, et al. J Infect Dis. 2018; doi: 10.1093/infdis/jiy581.
Maternal neutralizing antibody responses have a role in preventing vertical transmission of hepatitis C virus, but not among women coinfected with…
In the Journals Plus

Drug-resistant UTI relapse tied to incorrect antibiotic therapy

Anesi JA, et al. Infect Control Hosp Epidemiol. 2018:doi:10.1017/ice.2018.254.
Patients with community-onset urinary tract infections caused by Enterobacteriaceae that are resistant to extended-spectrum cephalosporins are less…
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In the Journals PlusPerspective

‘Reassuring’ evidence shows statin use does not impact flu vaccine effectiveness

Havers FP, et al. Clin Infect Dis. 2018;doi:10.1093/cid/ciy780/5145968.
Findings from a large observational study showed that statin use had no impact on influenza vaccine effectiveness in patients aged 45 years and…
In the Journals PlusPerspective

Prevalence of health care-associated infections falls to 3.2% in US

Magill SS, et al. N Engl J Med. 2018:doi:10.1056/NEJMoa1801550.
The prevalence of health care-associated infections in hospital patients in the United States decreased from 4% in 2011 to 3.2% in 2015, largely…
In the Journals Plus

Compensation for ID physicians ‘not a simple issue to fix’

Zahn M, et al. Clin Infect Dis. 2018;doi:10.1093/cid/ciy888.
Compensation policy changes are needed to attract more medical students and residents to the field of infectious diseases, where physicians are…
In the Journals Plus

Oral, gut decontamination does not reduce bloodstream infections in ICU

Vandenbroucke-Grauls CMJE, van der Meer JWM. JAMA. 2018;doi:10.1001/jama.2018.13764.
Wittekamp BH, et al. JAMA. 2018;doi:10.1001/jama.2018.13765.
Results of a randomized clinical trial showed that selective oral or digestive tract decontamination is not associated with reductions in…
In the Journals PlusPerspective

Fluorescent imaging probe quickly detects gram-negative bacteria in lungs

Akram AR, et al. Sci Transl Med. 2018;doi:10.1126/scitranslmed.aal0033.
Researchers developed a fluorescent imaging probe that can visualize gram-negative bacteria in human lungs in real time and reported that it was…
In the Journals Plus

Reducing unneeded central venous catheter use prevents CLABSIs

Xiong Z, et al. Infect Control Hosp Epidemiol. 2018; doi: 10.1017/ice.2018.250
A systematic literature review showed that interventions to reduce unnecessary central venous catheter use can significantly decrease the rate of…
In the Journals Plus

WHO-endorsed tests miss MDR-TB cases

Makhado NA, et al. Lancet Infect Dis. 2018;
WHO-endorsed tests did not detect a substantial number of multidrug-resistant tuberculosis, or MDR-TB, cases in South Africa that harbor a certain…
In the Journals Plus

Vaccine, nivolumab combination appears promising in recurrent HPV-related cancer

Massarelli E, et al. JAMA Oncol.2018;doi:10.1001/jamaoncol.2018.4051.
Treatment with a novel, synthetic, long-peptide HPV-16 vaccine plus nivolumab yielded promising response rates and survival outcomes among a small…
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