EXPERT SUMMARIES of the top 30 journals in infectious disease
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In the Journals Plus

No advantage in adding meropenem to colistin for A. baumannii infections

Paul M, et al. Lancet Infect Dis. 2018;doi:10.1016/S1473-3099(18)30099-9.
Perez F, Bonomo RA. Lancet Infect Dis. 2018;doi:10.1016/S1473-3099(18)30112-9.
Adding meropenem to colistin does not result in better outcomes compared with colistin monotherapy in hospital patients with severe infections caused…
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Infectious, autoimmune encephalitis show similar incidence, prevalence

Dubey D, et al. Ann Neurol. 2018;doi:10.1002/ana.25131.
Findings recently published in Annals of Neurology indicate that autoimmune encephalitis has an incidence and prevalence similar to that of…
In the Journals Plus

Extending interferon treatment duration for chronic delta hepatitis improves outcomes

Yurdaydin C, et al. J Infect Dis. 2018;doi:10.1093/infdis/jix656.
Interferon treatment lasting longer than 2 years for chronic delta hepatitis, or CDH, increases virologic response and “favorably affects the…
In the Journals Plus

Contaminated HCDs cause up to 282 cases of M. chimaera per year

Sommerstein R, et al. Emerg Infect Dis. 2018;doi:10.3201/eid2403.171554.
Globally, contaminated heater-cooler devices used during cardiac surgery may cause up to 282 cases of invasive Mycobacterium chimaera infection each…
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Current WHO strategy not enough to eliminate yaws, researchers say

Mitjà O, et al. Lancet. 2018;doi:10.1016/S0140-6736(18)30204-6.
Šmajs D, Pospíšilová P. Lancet. 2018;doi:10.1016/S0140-6736(18)30205-8.
A WHO-adopted strategy that aims to eliminate yaws in endemic areas through the mass administration of a single round of azithromycin significantly…
In the Journals Plus

Statin use does not ‘substantially’ increase risk for influenza

Izurieta HS, et al. Clin Infect Dis.2018;doi10.1093/cidciy4846330.
Researchers have concluded that although high-intensity statin users experienced a greater risk for influenza-related medical encounters after…
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Antimalarial resistance spread undetected for 5 years in Cambodia

Amato R, et al. Lancet Infect Dis. 2018;doi:10.1016/S1473-3099(18)30068-9.
A genomic analysis of malaria parasites in Cambodia revealed that resistance to first-line treatment with dihydroartemisinin-piperaquine emerged as…
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Combining HIV drug dolutegravir with TB therapy causes ‘serious toxicities’

Brooks KM, et al. Clin Infect Dis. 2018;doi:10.1093/cid/ciy082.
A study examining pharmacokinetic interactions between the first-line HIV drug dolutegravir and a once-weekly tuberculosis regimen was terminated…
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Asian, European ancestry linked with greater susceptibility to dengue shock syndrome

Oliveira M, et al. Plos Negl Trop Med. 2018;doi:10.1371/journal.pntd.0006202.
Patients of Asian or European descent often have genetic variants that make them more susceptible to dengue shock syndrome than patients of African…
In the Journals PlusPerspective

New C. difficile guidelines include testing, therapy changes

McDonald LC, et al. Clin Infect Dis. 2018;doi:10.1093/cid/cix1085.
Newly released practice guidelines for Clostridium difficile infection, or CDI, in both adults and children include changes in diagnostics and…
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Two-thirds of antibiotic combinations sold illegally in India

McGettigan P, et al. Br J Clin Pharmacol. 2018;doi:10.1111/bcp.13503.
Researchers found that 64% of fixed-dose antibiotic combinations were sold illegally in India over a 5-year period. Many of these unapproved…
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Valley fever outbreaks more widespread than previously thought

Freedman M, et al. Emerg Infect Dis. 2018;doi:10.3201/eid2403.170623.
Outbreaks of coccidioidomycosis, known as valley fever, have reached beyond areas in which it was previously considered endemic, and most stem from…
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Truvada as HIV PrEP not associated with net fat increase

Glidden DV, et al. Clin Infect Dis. 2018;doi:10.1093/cid/ciy083.
Truvada does not lead to an increase in fat mass when used for pre-exposure prophylaxis in people at risk for HIV, according to researchers. Data…
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Experimental RSV vaccine shows promise in phase 2 trials

Beran J, et al. J Infect Dis. 2018;doi:10.1093/infdis/jiy065.
An experimental vaccine for respiratory syncytial virus, or RSV, boosted pre-existing immune responses in young women and had a safety profile…
In the Journals Plus

Blue dye blocks malaria transmission

Dicko A, et al. Lancet Infect Dis. 2018;doi:10.1016/S1473-3099(18)30044-6.
Price RN, White NJ. Lancet Infect Dis. 2018;doi:10.1016/S1473-3099(18)30070-7.
Adding methylene blue to artemisinin-based combination therapy was safe in patients with malaria and resulted in faster parasite clearance than…

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