EXPERT SUMMARIES of the top 30 journals in infectious disease
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In the Journals Plus

Cadazolid inferior to vancomycin for treating C. difficile

Gerding DN, et al. Lancet Infect Dis. 2019;doi:10.1016/ S1473-3099(18)3061.
Phase 3 study findings showed that cadazolid is inferior to vancomycin for treating Clostridioides difficile. Johnson & Johnson had been…
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Patients with sickle cell disease may have lower risk for C. difficile

Ahmed J, et al. N Engl J Med. 2019;doi:10.1056/NEJMc1815711.
Findings from a retrospective cohort study conducted at a single hospital suggest that patients with sickle cell disease have a lower — and not…
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Influenza A causes more severe illness, delayed clinical improvement

Wang Y, et al. Open Forum Infect Dis. 2019;doi:10.1093/ofid/ofz053.
In hospitalized patients, influenza A is associated with more severe illness and delayed clinical improvement compared with influenza B, according to…
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Karius Test identifies pathogens more quickly than standard tests

Blauwkamp TA, et al. Nat Microbiol. 2019;doi:10.1038/s41564-018-0349-6.
The Karius Test has been validated for detecting pathogens and shown to identify quicker than test, according tostudy published in Nature
In the Journals Plus

Aerosol transmission of CRAB possible from ventilated patients

Mousa M, et al. Infect Control Hosp Epidemiol. 2019;doi:10.1017/ice.2018.335.
Researchers detected carbapenem-resistant Acinetobacter baumannii, or CRAB, in the air adjacent to ventilated patients with CRAB respiratory…
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Two-thirds of hospital-onset bacteremia, fungemia are preventable

Dantes RB, et al. Infect Control Hosp Epidemiol. 2019;doi:10.1017/ice.2018.339.
Two-thirds of all hospital-onset bacteremia and fungemia, or HOB, events and half of nonskin commensal HOB events are potentially preventable…
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Electronically delivered feedback reduces antibiotic prescribing for RTIs

Gulliford MC, et al. BMJ. 2019;doi:10.1136/bmj.l236.
Electronically delivered prescribing feedback led to “moderate” reductions in unnecessary antibiotic prescribing for respiratory tract…
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Data show 'clear evidence' of HPV vaccine impact on cervical precancer

McClung NM, et al. Cancer Epidemiol Biomarkers Prev. 2019;doi:10.1158/1055-9965.EPI-18-0885.
The proportion of cervical precancers positive for HPV types 16 and 18 declined significantly between 2008 and 2014, particularly among vaccinated…
In the Journals Plus

Analysis shows ‘meaningful’ decline in outpatient antibiotics in New England

Cocoros NM, et al. Infect Control Hosp Epidemiol. 2019;doi:10.1017/ice.2018.341.
An examination of outpatient antibiotics dispensed within a single commercial health insurance plan in New England showed a “meaningful”…
In the Journals Plus

HIV status does not preclude receipt of curative cervical cancer therapy in Botswana

Grover S, et al. Cancer. 2019;doi:10.1002/cncr.31972.
Little RF. Cancer. 2019;doi:10.1002/cncr.31974.
Women in Botswana with well-managed HIV had the same access to curative chemoradiotherapy for cervical cancer as women without HIV, according to…
In the Journals

Spray bleach significantly reduces C. difficile spores in non-CDI rooms

Wong, YKN, et al. Am J Infect Control. 2019;doi:10.1016/j.ajic.2018.12.023.
A recent study found that using a spray bleach for post-discharge cleaning significantly reduced the recovery of Clostridioides
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Vaginal TFV gel may protect against HSV-2 in women

Marrazzo JM, et al. J Infect Dis. 2019;doi:10.1093/infdis/jiz045.
After controlling for sexual behavior and HIV-1 acquisition, adherence to vaginal tenofovir gel was associated with a trend toward reduced risk for…
In the Journals Plus

HIV infection linked to shorter survival in hepatocellular carcinoma

Pinato D, et al. J Clin Oncol. 2018;doi:10.1200/JCO.18.00885.
HIV seropositivity appeared associated with shorter OS among patients with hepatocellular carcinoma despite sufficient antiretroviral treatment…
In the Journals Plus

High-dose flu vaccine more effective than standard vaccines in older adults

Young-Xu Y, et al. Vaccine. 2019;doi:10.1016/j.vaccine.2019.01.063.
Compared with standard-dose influenza vaccines, the high-dose vaccine is more effective in preventing influenza- or pneumonia-associated…
In the Journals Plus

Hospital halves urine cultures by encouraging urinalysis reflex testing

Munigala S, et al. Infect Control Hosp Epidemiol. 2019;doi:10.1017/ice.2018.356.  
An intervention that included changing the electronic ordering system to encourage urinalysis reflex testing for suspected urinary tract infections…
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