EXPERT SUMMARIES of the top 30 journals in infectious disease
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In the Journals Plus

Cadazolid inferior to vancomycin for treating C. difficile

Gerding DN, et al. Lancet Infect Dis. 2019;doi:10.1016/ S1473-3099(18)3061.
Phase 3 study findings showed that cadazolid is inferior to vancomycin for treating Clostridioides difficile. Johnson & Johnson had been…
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Patients with sickle cell disease may have lower risk for C. difficile

Ahmed J, et al. N Engl J Med. 2019;doi:10.1056/NEJMc1815711.
Findings from a retrospective cohort study conducted at a single hospital suggest that patients with sickle cell disease have a lower — and not…
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Influenza A causes more severe illness, delayed clinical improvement

Wang Y, et al. Open Forum Infect Dis. 2019;doi:10.1093/ofid/ofz053.
In hospitalized patients, influenza A is associated with more severe illness and delayed clinical improvement compared with influenza B, according to…
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Karius Test identifies pathogens more quickly than standard tests

Blauwkamp TA, et al. Nat Microbiol. 2019;doi:10.1038/s41564-018-0349-6.
The Karius Test has been validated for detecting pathogens and shown to identify quicker than test, according tostudy published in Nature
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Aerosol transmission of CRAB possible from ventilated patients

Mousa M, et al. Infect Control Hosp Epidemiol. 2019;doi:10.1017/ice.2018.335.
Researchers detected carbapenem-resistant Acinetobacter baumannii, or CRAB, in the air adjacent to ventilated patients with CRAB respiratory…
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Two-thirds of hospital-onset bacteremia, fungemia are preventable

Dantes RB, et al. Infect Control Hosp Epidemiol. 2019;doi:10.1017/ice.2018.339.
Two-thirds of all hospital-onset bacteremia and fungemia, or HOB, events and half of nonskin commensal HOB events are potentially preventable…
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Electronically delivered feedback reduces antibiotic prescribing for RTIs

Gulliford MC, et al. BMJ. 2019;doi:10.1136/bmj.l236.
Electronically delivered prescribing feedback led to “moderate” reductions in unnecessary antibiotic prescribing for respiratory tract…
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Data show 'clear evidence' of HPV vaccine impact on cervical precancer

McClung NM, et al. Cancer Epidemiol Biomarkers Prev. 2019;doi:10.1158/1055-9965.EPI-18-0885.
The proportion of cervical precancers positive for HPV types 16 and 18 declined significantly between 2008 and 2014, particularly among vaccinated…
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Analysis shows ‘meaningful’ decline in outpatient antibiotics in New England

Cocoros NM, et al. Infect Control Hosp Epidemiol. 2019;doi:10.1017/ice.2018.341.
An examination of outpatient antibiotics dispensed within a single commercial health insurance plan in New England showed a “meaningful”…
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HIV status does not preclude receipt of curative cervical cancer therapy in Botswana

Grover S, et al. Cancer. 2019;doi:10.1002/cncr.31972.
Little RF. Cancer. 2019;doi:10.1002/cncr.31974.
Women in Botswana with well-managed HIV had the same access to curative chemoradiotherapy for cervical cancer as women without HIV, according to…
In the Journals

Spray bleach significantly reduces C. difficile spores in non-CDI rooms

Wong, YKN, et al. Am J Infect Control. 2019;doi:10.1016/j.ajic.2018.12.023.
A recent study found that using a spray bleach for post-discharge cleaning significantly reduced the recovery of Clostridioides
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Vaginal TFV gel may protect against HSV-2 in women

Marrazzo JM, et al. J Infect Dis. 2019;doi:10.1093/infdis/jiz045.
After controlling for sexual behavior and HIV-1 acquisition, adherence to vaginal tenofovir gel was associated with a trend toward reduced risk for…
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HIV infection linked to shorter survival in hepatocellular carcinoma

Pinato D, et al. J Clin Oncol. 2018;doi:10.1200/JCO.18.00885.
HIV seropositivity appeared associated with shorter OS among patients with hepatocellular carcinoma despite sufficient antiretroviral treatment…
In the Journals Plus

High-dose flu vaccine more effective than standard vaccines in older adults

Young-Xu Y, et al. Vaccine. 2019;doi:10.1016/j.vaccine.2019.01.063.
Compared with standard-dose influenza vaccines, the high-dose vaccine is more effective in preventing influenza- or pneumonia-associated…
In the Journals Plus

Hospital halves urine cultures by encouraging urinalysis reflex testing

Munigala S, et al. Infect Control Hosp Epidemiol. 2019;doi:10.1017/ice.2018.356.  
An intervention that included changing the electronic ordering system to encourage urinalysis reflex testing for suspected urinary tract infections…
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