Trial to assess CAR T-cell therapy for HER2-positive metastatic breast cancer

January 19, 2019
Researchers at City of Hope have opened a first-in-human clinical trial to assess the use of chimeric antigen receptor T-cell therapy for patients…

CIMAvax-nivolumab combination appears safe, demonstrates ‘good signals’ in advanced lung cancer

January 18, 2019
The Cuban-developed immunotherapy CIMAvax-EGF in combination with nivolumab appeared safe for patients with advanced non-small cell lung cancer…

‘Cancer-agnostic’ NTRK inhibitor approval ushers in paradigm of personalized genomics-guided therapeutics

HemOnc Today, January 10, 2019
Patrick C. Ma, MD, MSc
On Nov. 26, the FDA announced the accelerated approval of larotrectinib as the first small molecule inhibitor for use in a…
Cover Story

Checkpoint inhibition and rheumatic events: ‘Many more questions than answers’

HemOnc Today, January 10, 2019
It may seem silly to use Whac-A-Mole to illustrate a key challenge in cancer treatment. But the popular arcade game’s basic premise — use…

NCI grant to fund study of CAR T-cell therapy for solid tumors

January 2, 2019
A $10.7 million grant from NCI will fund research at University of Pennsylvania’s Abramson Cancer Center to evaluate the use of chimeric…

ASH launches sickle cell disease clinical trials network to accelerate therapy development

December 31, 2018
ASH launched a clinical trials network designed to accelerate development of novel therapies for patients with sickle cell disease. The network will…
FDA News

FDA issues new framework for oncology drug development

December 19, 2018
The FDA today issued new guidance to help drug developers select endpoints for marketing applications with the goal of advancing the efficient…
Meeting News

B-cell maturation antigen-targeted CAR T-cell therapy potent in advanced myeloma

December 17, 2018
SAN DIEGO — B-cell maturation antigen chimeric antigen receptor T cells that harbor a fully human single-chain variable fragment with a defined…

Precision immunotherapy: Giving the right drug to the right patient at the right time

HemOnc Today, December 10, 2018
Razelle Kurzrock, MD; Vivek Subbiah, MD
James P. Allison, PhD, of the United States, and Tasuku Honjo, MD, PhD, of Japan, received the 2018 Nobel Prize in Physiology or Medicine for their…

NIH initiative takes ‘multiple-shots’ approach toward cure for sickle cell disease

November 29, 2018
The NIH launched an initiative to coordinate and accelerate research into a cure for sickle cell disease. W. Keith Hoots, MD, director of the…