ASTRO Annual Meeting
MIAMI - One- and 2-year OS rates were similar for patients who underwent
multifractional stereotactic body radiation therapy compared with patients who
underwent single daily fractions, according to results of a 2-year study at
Mayo Clinic in Rochester.
In results presented in a poster at the 2011 ASTRO Annual Meeting,
researchers analyzed 85 spinal lesions diagnosed in 66 patients from April 2008
to December 2010. Thirty-two lesions were treated with a single daily fraction
to a median of 18 Gy, and 52 patients were treated with multiple daily
fractions to a median of 24 Gy. Median spinal cord maximum dose was 12.6 Gy
(7.8 Gy-17.3 Gy) in the single fractionation schedule and 17.6 Gy (8.6 Gy-44.3
Gy) in the multifractional schedule.
One-year OS was 55% in the single fractionation group and 51% in the
multifractional group. Two-year OS was 33% vs. 41% in favor of the
At 2 years, local control rate as 80% in the single fraction group vs.
85% in the multifractional group. Two patients had local failure in the single
fraction group compared with six in the multifractional group.
There were no differences in actuarial survival or local control between
There was one incident of grade-3 toxicity in each group.
Researchers said the multifractionated treatment schedule with epidural
disease does not compromise local control rates, but further study is needed to
determine long-term control and toxicity.
For more information:
- Ahmed KA. #2167. Presented at: the 2011 ASTRO Annual Meeting; Oct.
Disclosure: The researchers report no relevant financial disclosures.