EXPERT SUMMARIES of the top 30 journals in hematology & oncology
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High-dose chemotherapy improves survival in Ewing sarcoma

Whelan J, et al. J Clin Oncol. 2018;doi:10.1200/JCO.2018.78.2516.
Gorlick R, et al. J Clin Oncol. 2018;doi:10.1200/JCO.2018.79.3489.
A high-dose combination of busulfan and melphalan with autologous stem cell transplant improved survival compared with standard-of-care vincristine…
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Brentuximab vedotin plus gemcitabine safe, active for young patients with Hodgkin lymphoma

Cole PD, et al. Lancet Oncol. 2018;doi:10.1016/S1470-2045(18)30426-1.
Vitolo U and Chiappella A. Lancet Oncol. 2018;doi:10.1016/S1470-2045(18)30510-2.
Salvage treatment with the combination of brentuximab vedotin and gemcitabine showed antitumor activity among children and young adults with…
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Study data reveal ‘complexity’ of evaluating benefit of breast cancer screening

Beau AB, et al. J Clin Oncol. 2018;doi:10.1200/JCO.2018.78.0270.
Inviting women to mammography screenings may reduce breast cancer mortality by up to 20%, according to retrospective study of Danish national…
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Immediate compression offers 'clear benefit' following blood clot

Amin EE, et al. Blood. 2018;doi:10.1182/blood-2018-03-836783.
Patients with deep vein thrombosis who underwent immediate compression therapy had significantly lower rates of residual vein obstruction and…
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Tool predicts risk for late breast cancer recurrence

Dowsett M, et al. J Clin Oncol. 2018;doi:10.1200/JCO.2017.76.4258.
An online prognostic tool accurately determined the risk for late distant recurrence among women with ER-positive breast cancer, according to a…
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Brentuximab vedotin data ‘practice changing’ for older patients with Hodgkin lymphoma

Evens AM, et al. J Clin Oncol. 2018;doi:10.1200/JCO.2018.79.0139.
Brentuximab vedotin administered sequentially before and after standard chemotherapy appeared effective and safe for older patients with previously…
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Dose-dense chemotherapy improves bladder cancer outcomes following cystectomy

Peyton CC, et al. JAMA Oncol. 2018;doi:10.1001/jamaoncol.2018.3542.
Neoadjuvant chemotherapy comprised of a dose-dense combination of methotrexate, vinblastine, doxorubicin and cisplatin improved response rates among…
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Low-cost genetic test spurs ‘cascade testing’ among relatives

Caswell-Jin JL, et al. J Natl Cancer Inst. 2018;doi:10.1093/jncl/djy147.
Nearly half of people closely related to carriers of cancer-associated genes accepted invitations to undergo low-cost genetic testing to assess their…
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Blood test could reduce unnecessary biopsies of lung nodules

Nasrallah NA and Sears CR. CHEST. 2018;doi:10.1016/j.chest.2018.04.032.
Silvestri GA, et al. CHEST. 2018;doi:10.1016/j.chest.2018.02.012.
A risk-assessment test that combined levels of plasma proteins and clinical factors accurately determined whether pulmonary nodules were benign or…
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Anti-inflammatory may improve colon cancer surgery outcomes

Redmond HP, et al. BMC Cancer. 2018;10.1186/s12885-018-4641-x.
The anti-inflammatory and anti-neoplastic agent taurolidine significantly decreased IL-6 levels in patients undergoing colon cancer surgery…
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Chemotherapy combination appears safe for elderly patients with acute myeloid leukemia

Kadia TM, et al. Lancet Haematol. 2018;doi:10.1016/S2352-3026(18)30132-7.
Vey N. Lancet Haematol. 2018;doi:10.1016/S2352-3026(18)30136-4.
Treatment with the combination of cladribine and low-dose cytarabine alternating with decitabine appeared safe and effective among older patients…
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Supportive therapy alleviates depression associated with advanced cancer

Rodin G, et al. J Clin Oncol. 2018.doi;10.1200/JCO.2017.77.1097.
Patients with advanced cancer experienced alleviated
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Obinutuzumab-venetoclax shows activity for chronic lymphocytic leukemia

Cramer P, et al. Lancet Oncol. 2018;doi:10.1016/S1470-2045(18)30414-5.
Kallam A and Armitage JO. Lancet Oncol. 2018;doi:10.1016/S1470-2045(18)30442-X.
Bendamustine followed by obinutuzumab and venetoclax appeared safe and effective for treatment of patients with chronic lymphocytic leukemia…
In the Journals Plus

Fatal toxic events possible, but rare, with immune checkpoint inhibitors

Wang DY, et al. JAMA Oncol. 2018;doi:10.1001/jamaoncol.2018.3923.
Fatal toxic events occurred in about 0.3% to 1.3% of patients treated with immune checkpoint inhibitors, according to a meta-analysis of adverse…
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Persistent mutations in bone marrow associated with poor myelodysplastic syndrome outcomes

Duncavage EJ, et al. N Engl J Med. 2018;doi:10.1056/NEJMoa1804714.
Patients with myelodysplastic syndrome who had persistent mutations detected in bone marrow samples after allogeneic hematopoietic stem cell…
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