EXPERT SUMMARIES of the top 30 journals in hematology & oncology
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Highly educated patients with acute myeloid leukemia show better survival in a universal health system

Østgård LS, et al. J Clin Oncol. 2017;doi:10.1200/JCO.2017.73.6728.
Education level impacted allogeneic hematopoietic stem cell transplantation rates among younger patients with acute myeloid leukemia in a country…
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Lenvatinib effective for differentiated thyroid cancer despite adverse effects

Amandine B, et al. Thyroid. 2017;doi:10.1089/thy.2017.0205.
The use of lenvatinib for the treatment of radioiodine-refractory differentiated thyroid cancer in adults was relatively effective, but adverse…
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Fewer newly diagnosed patients with cancer lack insurance after ACA

Soni A, et al. JAMA Oncol. 2017;doi:10.1001/jamaoncol.2017.3176.
Uninsurance rates among patients newly diagnosed with cancer dropped one-third during the Affordable Care Act’s first year of implementation…
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Favorable outcomes seen for lung-only metastatic thyroid cancer

Sohn SY, et al. Clin Endocrinol. 2017;doi:10.1111/cen.13489.
Results of a retrospective study conducted in South Korea demonstrated that most patients with metastatic differentiated thyroid cancer confined to
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Hydroxyurea appears safe for African children with sickle cell anemia

Opoka RO, et al. Blood. 2017;doi:10.1182/blood-2017-06-788935.
Hydroxyurea did not increase the risk for malaria infection in children with sickle cell anemia who live in malaria-endemic regions of Uganda…
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Malignant thyroid nodules grow faster than benign nodules

Angell TE, et al. J Clin Endocrinol Metab. 2017;doi:10.1210/jc.2017-01832.
Malignant thyroid nodules are more likely to grow at least 2 mm per year and increase in volume compared with benign thyroid nodules, according to…
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Mortality risk greater for male transfusion recipients with previously pregnant donor

Caram-Deelder, et al. JAMA. 2017;doi:10.1001/jama.2017.14825.
Men who received red blood cell transfusions from women who had ever been pregnant appeared to have an increased risk for death, according to results…
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Cancer site distribution does not vary with sexual orientation

Saunders CL, et al. J Clin Oncol. 2017;doi:10.1200/JCO.2017.72.5465.
Sexual orientation of patients with cancer did not appear to influence the distribution of disease sites, according to researchers in the United
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Cadmium exposure may increase risk for endometrial cancer

McElroy JA, et al. PLoS ONE. 2017;doi:10.1371/journal.pone.0179360.
Women with high levels of cadmium exposure appeared to have increased risk for endometrial cancer, according to a population-based, case-control…
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Genetic variant predicts clinical response to prostate cancer therapy

Almassi N, et al. JAMA Oncol. 2017;doi:10.1001/jamaoncol.2017.3159.
Hearn JWD, et al. JAMA Oncol. 2017;doi:10.1001/jamaoncol.2017.3164.
The presence of HSD3B1 variant predicted clinical outcomes to certain therapies among men treated for localized and metastatic castration-resistant…
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Hospitalization burden heavy after advanced cancer diagnosis

Whitney RL, et al. J Clin Oncol. 2017;doi:10.1200/JCO.2017.72.4963.
Patients with advanced cancer face a heavy burden of hospitalization in the year following diagnosis, study data showed. Researchers recommended
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Venetoclax-based regimen may extend survival in multiple myeloma

Moreau P, et al. Blood. 2017;doi:10.1182/blood-2017-06-788323.
Venetoclax with bortezomib and dexamethasone demonstrated an acceptable safety profile and promising efficacy among patients with relapsed or…
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Antibody drug conjugate shows promise for metastatic colorectal cancer

Dotan E, et al. J Clin Oncol. 2017;doi:10.1200/JCO.2017.73.9011.
Labetuzumab govitecan monotherapy appeared safe and demonstrated activity in heavily pretreated patients with metastatic colorectal cancer, according…
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Pretransplant vitamin D deficiency may heighten relapse risk in myeloid malignancies

Radujkovic A, et al. J Clin Oncol. 2017;doi:10.1200/JCO.2017.73.0085.
A deficiency in vitamin D prior to allogeneic hematopoietic stem cell transplantation increased risk for relapse among patients with myeloid…
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Multimodal therapy increases anaplastic thyroid cancer survival

Prasongsook N, et al. J Clin Endocrinol Metab. 2017;doi:10.1210/jc.2017-01180.
Adults who receive intensive multimodal therapy for treatment of anaplastic thyroid cancer are likely to have longer progression-free survival and…
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