EXPERT SUMMARIES of the top 30 journals in hematology & oncology
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In the Journals Plus

Genetic testing guidelines miss nearly 50% of breast cancers with actionable variants

Beitsch PD, et al. J Clin Oncol. 2018;doi:10.1200/JCO.18.01631.
Milliron KJ and Griggs JJ. J Clin Oncol. 2018;doi:10.1200/JCO.18.01952.
Nearly half of patients whose breast cancer is revealed by expanded genetic testing to have a clinically actionable pathogenic or likely pathogenic…
In the Journals PlusPerspective

Cytoreductive surgery with chemotherapy often safer than other high-risk oncologic procedures

Foster J, et al. JAMA Netw. Open. 2019;doi:10.1001/jamanetworkopen.2018.6847.
Smith M and Nathan H. JAMA Netw. Open. 2019;doi:10.1001/jamanetworkopen.2018.6839.
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy proved to be as safe as or safer than other oncologic procedures with similar…
In the Journals Plus

Cervical cancer study suggests ‘global elimination is within reach’

Brisson M and Drolet M. Lancet Oncol. 2019;doi:10.1016/S1470-2045(19)30072-5.
Simms KT, et al. Lancet Oncol. 2019;doi:10.1016/S1470-2045(18)30836-2.
A rapid scale-up of HPV vaccination and screening could effectively eliminate
In the Journals Plus

Data show 'clear evidence' of HPV vaccine impact on cervical precancer

McClung NM, et al. Cancer Epidemiol Biomarkers Prev. 2019;doi:10.1158/1055-9965.EPI-18-0885.
The proportion of cervical precancers positive for HPV types 16 and 18 declined significantly between 2008 and 2014, particularly among vaccinated…
In the Journals PlusPerspective

Direct oral anticoagulants do not increase incidence of intracranial hemorrhage

Carney, BJ, et al. J Thromb Haemost. 2019;doi:10.1111/jth.14336.
Direct oral anticoagulants did not appear associated with a higher incidence of intracranial hemorrhage compared with low-molecular-weight heparin in…
In the Journals Plus

HIV status does not preclude receipt of curative cervical cancer therapy in Botswana

Grover S, et al. Cancer. 2019;doi:10.1002/cncr.31972.
Little RF. Cancer. 2019;doi:10.1002/cncr.31974.
Women in Botswana with well-managed HIV had the same access to curative chemoradiotherapy for cervical cancer as women without HIV, according to…
In the Journals Plus

Mismatch repair deficiency linked to increased risk for endometrial cancer recurrence

Backes FJ, et al. Cancer. 2018;doi:10.1002/cncr.31901.
Eskander RN. Cancer. 2018; doi:10.1002/cncr.31902.
Women with high-intermediate-risk endometrioid endometrial cancer and defective DNA mismatch repair had higher recurrence rates and poorer RFS than…
In the Journals Plus

Apixaban superior to rivaroxaban in preventing recurrent venous thromboembolism, major bleeding

Dawwas G, et al. Lancet Haematol. 2018;doi:10.1016/S2352-3026(18)30191-1.
Frere C and Farge D. Lancet Haematol. 2018;doi:10.1016/S2352-3026(18)30211-4.
Apixaban appeared more effective than rivaroxaban in preventing recurrent venous thromboembolism without major bleeding events, according to results…
In the Journals Plus

Marker of inflammation associated with depression in patients with lung cancer

McFarland, D et al. Cancer. 2018;doi:10.1002/cncr.31859
Elevated C-reactive protein, a marker of systemic inflammation, appeared associated with depression among patients with metastatic lung cancer…
In the Journals Plus

Direct oral anticoagulants safe, effective in patients with VTE and thrombophilia

Elsebaie MA, et al. J Thromb Haemost. 2019;doi:10.1111/jth.14398.
Patients with thrombophilia had low rates of venous thromboembolism recurrence and bleeding events after treatment with direct oral anticoagulants…
In the Journals Plus

HIV infection linked to shorter survival in hepatocellular carcinoma

Pinato D, et al. J Clin Oncol. 2018;doi:10.1200/JCO.18.00885.
HIV seropositivity appeared associated with shorter OS among patients with hepatocellular carcinoma despite sufficient antiretroviral treatment…
In the Journals PlusPerspective

Breast cancer metastasis risk remains elevated 10 years after childbirth

Goddard ET, et al. JAMA Netw Open. 2019;doi:10.1001/jamanetworkopen.2018.6997.
Women diagnosed with stage 1 or stage 2 postpartum breast cancer up to 10 years after giving birth may be at increased risk for distant metastasis…
In the Journals Plus

Rivaroxaban decreases VTE incidence during intervention period among patients with cancer

Agnelli G, et al. N Engl J Med. 2019;doi:10.1056/NEJMe1816060.
Khorana AA, et al. N Engl J Med. 2019;doi:10.1056/NEJMoa1814630.
Rivaroxaban led to substantially lower incidence of venous thromboembolism and death of VTE among ambulatory patients with cancer death during the…
In the Journals Plus

Cancer death rates declining faster among blacks than whites, but disparities persist

DeSantis CE, et al. CA Cancer J Clin. 2019;doi:10.3322/caac.21555.
Overall cancer death rates are dropping faster among black Americans than white Americans, according to a report published in CA: A Cancer Journal
In the Journals Plus

Filgrastim use increases risk for myelodysplastic syndrome, AML in non-Hodgkin lymphoma

Calip G, et al. Cancer. 2018;doi:10.1002/cncr.31914,
Use of the granulocyte colony-stimulating factor filgrastim appeared associated with a higher risk for myelodysplastic syndrome and acute myeloid…
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