EXPERT SUMMARIES of the top 30 journals in hematology & oncology
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FOLFOXIRI plus cetuximab active, feasible for metastatic colorectal cancer

Cremolini C, et al. JAMA Oncol. 2018;doi:10.1001/jamaoncol.2017.5314.
A 4-month course of induction therapy with modified FOLFOXIRI and cetuximab produced significant activity and appeared feasible for patients with…
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Insurers’ cost for chemotherapy varies across delivery location

Winn AN, et al. JAMA Oncol. 2018;doi:10.1001/jamaoncol.2017.5544.
Delivering infused chemotherapy in a physician’s office cost commercial health insurers less than chemotherapy administered in a hospital…
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Larotrectinib active, safe in certain fusion-positive cancers

Drilon A, et al. N Engl J Med. 2018;doi:10.1056/NEJMoa1714448.
Larotrectinib showed activity in adults and children with TRK fusion-positive cancers, according to findings published in The New England Journal of
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High estrogen receptor heterogeneity doubles breast cancer mortality risk

Lindström LS, et al. J Natl Cancer Inst. 2018;doi:10.1093/jnci/djx270.
Postmenopausal women with breast cancer with high intratumor heterogeneity of ER had an increased long-term risk for death of breast cancer…
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Targeted radiation reduces mortality for early-stage lung cancer

Stokes WA, et al. J Clin Oncol. 2018;doi:10.1200/JCO.2017.75.6536.
Stereotactic body radiation therapy conferred lower 30-day and 90-day mortality rates than surgery among patients with early-stage non-small cell…
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Study identifies racial disparities in multiple myeloma treatment, outcomes

Ailawadhi S, et al. Cancer. 2018;doi:10.1002/cncr.31237.
Outcomes for patients with multiple myeloma treatment appeared to substantially improve in recent years, according to findings published in…
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Fluids extend survival at end of life for patients with cancer

Davies AN, et al. Palliat Med. 2018;doi:10.1177/0269216317741572.
Patients with cancer at end of life who received assisted hydration survived nearly 1.5 days longer than those who did not receive fluids, according…
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Fracture incidence in thyroid cancer linked to levothyroxine dose

Shin DW, et al. J Bone Miner Res. 2018;doi:10.1002/jbmr.3407.
Adults with thyroid cancer taking less than 115 µg per day or at least 145 µg per day of levothyroxine after thyroidectomy or radioiodine ablation…
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Mothers of children with cancer report lower income after diagnosis

Hiyoshi A, et al. Cancer. 2018;doi:10.1002/cncr.31123.
Over time, mothers, but not fathers, of children with cancer showed significantly lower income than parents of children without cancer, according to…
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Lifestyle factors associated with ischemic heart disease after hematopoietic cell transplantation

Leger KJ, et al. Cancer. 2018;doi:10.1002/cncr.31227.
Preventable lifestyle and cardiovascular factors appeared associated with ischemic heart disease and mortality among patients who had received…
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As obesity-related health costs rise, experts warn of far-reaching complications

Biener A, et al. Clin Chem. 2018;doi:10.1373/clinchem.2017.272450.
Obesity-related health care costs in the United States rose 29% between 2001 and 2015, and new data from the most populous states reveal that the…
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Accuracy of common prognostic signatures for breast cancer varies considerably

Sestak I, et al. JAMA Oncol. 2018;doi:10.1001/jamaoncol.2017.5524.
The accuracy of six prognostic signatures for ER-positive breast cancer varied widely in their ability to predict disease recurrence, according to…
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ASCO, NCCN release guidelines on managing immunotherapy toxicity

Brahmer JR, et al. J Clin Oncol. 2018;doi:10.1200/JCO.2017.77.6385.
Immune checkpoint inhibitor therapy should be discontinued when moderate to severe adverse events are present in treated patients, according to newly…
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Interactive educational website improves knowledge, decision-making for breast cancer treatment

Hawley S, et al. J Clin Oncol. 2018;doi:10.1200/JCO.2017.74.8442.
An interactive website improved knowledge and decision-making among patients with breast cancer, study data showed. “Knowledge is a key…
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Many oncology clinical pathways meet criteria for high quality

Daly B, et al. J Oncol Prac. 2018;doi:10.1200/JOP.17.00033.
Most available commercial oncology clinical pathways meet ASCO’s criteria for high-quality development, implementation and use, and analytics…

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