EXPERT SUMMARIES of the top 30 journals in hematology & oncology
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In the Journals Plus

Ibrutinib effective among patients with rare Bing-Neel syndrome

Castillo JJ, et al. Blood. 2018;doi:10.1182/blood-2018-10-879593.
Ibrutinib induced rapid and durable responses among patients with Bing-Neel syndrome, a condition that affects only about 1% of patients with…
In the Journals Plus

World Trade Center responders at increased risk for head and neck cancers

Graber J, et al. Int J Cancer. 2019;doi:10.1002/ijc.32070.
Rescue workers and volunteers who responded to the World Trade Center on 9/11 demonstrated a significantly increased risk for head and neck cancers…
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Treatment de-intensification fails to reduce toxicity, maintain efficacy in HPV-positive oropharyngeal cancer

Gillison MR, et al. The Lancet 2018;doi:10.1016/S0140-6736(18)32779-X.
Mehanna H, et al. The Lancet. 2018;doi:10.1016/S0140-6736(18)32752-1.
Oosthuizen JC, et al. The Lancet. 2018;doi:10.1016/S0140-6736(18)32930-1.
Patients with advanced, HPV-positive
In the Journals Plus

Some patients with renal cancer may not benefit from partial nephrectomy

Derweesh IH, et al. Cancer. 2018;doi:10.1002/cncr.31579.
Ristau BT, et al. Cancer. 2018;doi:10.1002/cncr.31582.
Although partial nephrectomy was associated with improved OS among patients with
In the Journals Plus

Higher platelet transfusion threshold increased risk for death among neonates with severe thrombocytopenia

Curley A, et al. N Engl J Med. 2019;doi:10.1056/NEJMoa1807320.
Sola-Visner MC. N Engl J Med. 2019;doi:10.1056/NEJMe1813419.
Higher platelet transfusion threshold appeared to increase risk for death and major bleeding among preterm infants with severe thrombocytopenia…
In the Journals Plus

Oncologists demonstrate limited knowledge about needs of LGBTQ patients but want more education

Schabath MB, et al. J Clin Oncol. 2019;10.1200/JCO.18.00551.
Oncologists at NCI-designated cancer centers demonstrated limited knowledge about the unique health needs of lesbian, gay, bisexual, transgender and…
In the Journals Plus

Smoking linked to poor neoadjuvant chemotherapy response, recurrence in bladder cancer

Boeri L, et al. BJU Int. 2019;doi:10.1111/bju.14612.
Cigarette smoking appeared significantly associated with poor pathological response to cisplatin-based neoadjuvant chemotherapy among patients with…
In the Journals Plus

Financial incentives may influence oncologists’ practice patterns

Mitchell A, et al. JAMA Oncol. 2019;doi:10.1001/jamaoncol.2018.6196.
Some oncologists may alter treatment recommendations for patients in some cases based on personal revenue considerations, according to results of a…
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Treatment at academic centers yields survival benefit in metastatic NSCLC

Ramalingam S, et al. J Thorac Oncol. 2018;doi:10.1016/j.jtho.2018.09.007.
In the Journals Plus

Black women, poor face barriers to breast cancer screening despite interventions

Kim SJ, et al. Cancer. 2018;doi:10.1002/cncr.31636.
Black women, women living in poverty, and women who expressed deep distrust of the health care system appeared less likely to report barriers to…
In the Journals Plus

No link between ADT, dementia among veterans with prostate cancer

Deka R, et al. JAMA Oncol. 2018;doi:10.1001/jamaoncol.2018.4423.
Androgen deprivation therapy did not appear to increase risk for dementia, vascular dementia or Alzheimer disease among veterans with nonmetastatic…
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Complication rates after invasive diagnostic lung procedures twice as high in community setting

Huo J, et al. JAMA Intern Med. 2019;doi:10.1001/jamainternmed.2018.6277.
Complications after invasive diagnostic procedures for lung abnormalities occurred twice as often in the real-world setting than in clinical trials…
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Organ-sparing treatment strategy appears promising in early-stage rectal cancer

Garcia-Aguilar J. JAMA Surg. 2018;doi:10.1001/jamasurg.2018.3760.
Stijns RCH, et al. JAMA Surg.2018;doi:10.1001/jamasurg.2018.3752.
Neoadjuvant chemoradiotherpy followed by transanal endoscopic microsurgery may be a viable alternative to conventional total mesorectal excision for…
In the Journals Plus

Modernized trial eligibility criteria aim to remove comorbidities as a barrier to enrollment

Unger J, et al. JAMA Oncol. 2019;doi:10.1001/jamaoncol.2018.5953.
Mishkin G, et al. JAMA Oncol. 2019;doi:10.1001/jamaoncol.2018.5949.
Patients with cancer and comorbidities are routinely left out of clinical trial discussions, offers and participation, according to results of a…
In the Journals Plus

Oral HT associated with risk for VTE

Vinogradova Y, et al. BMJ. 2019;doi:10.1136/bmj.k4810.
British women recently exposed to oral hormone therapy were 58% more likely to receive a primary diagnosis of venous thromboembolism than women not…
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