EXPERT SUMMARIES of the top 30 journals in hematology & oncology
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In the Journals Plus

Biomarker predicts prognosis in certain gynecological cancers

Nielsen B, et al. J Natl Cancer Inst. 2018;doi:10.1093/jnci/djy063.
Researchers identified chromatin entropy nuclei as a prognostic marker for patients with uterine sarcomas, ovarian carcinomas and endometrial…
In the JournalsPerspective

Laparoscopic radical cystectomy conferred favorable long-term survival outcomes

Albisinni S. BJU Int. 2014;doi:10.1111/bju.12947.
Patients with muscle-invasive or high-risk bladder cancer experienced favorable RFS, OS and cancer-specific survival outcomes after undergoing…
In the JournalsPerspective

Circulating neutrophil, monocyte, lymphocyte counts predict survival in HPV-positive oropharyngeal cancer

Huang SH. Cancer. 2014;doi:10.1002/cncr.29100.
Both high pretreatment circulating neutrophil and monocyte counts independently predicted shorter OS and RFS among patients with HPV-positive…
In the Journals

Aspirin, COX-2 inhibitors improved outcomes in stage III colon cancer

Ng K. J Natl Cancer Inst. 2014;doi:10.1093/jnci/dju345.
Patients with stage III colon cancer who used aspirin and COX-2 inhibitors demonstrated statistically significant reductions in risk for cancer…
In the Journals

Sickle cell trait increased risk for pulmonary embolism

Folsom AR. J Thromb Haemost. 2014;doi:10.1111/jth.12787.
African Americans with sickle cell trait appeared twice as likely to develop pulmonary embolism as those who did not carry sickle cell trait…
In the JournalsPerspective

Carboplatin–paclitaxel combination shows promise for rare form of thymus cancer

Hirai F. Ann Oncol. 2014;doi:10.1093/annonc/mdu541.
The combination of carboplatin and paclitaxel compared favorably with standard anthracycline-based chemotherapy in the treatment of thymic carcinoma…
In the Journals

Acid reflux medications may extend survival in HNSCC

Papagerakis S. Cancer Prev Res. 2014;doi:10.1158/1940-6207.CAPR-14-0002.
Two types of antacid medications commonly used by patients with head and neck squamous cell carcinoma to reduce acid reflux may provide a survival…
In the Journals

Women with BRCA-associated ovarian cancer have low risk for subsequent breast cancer

Gangi A. JAMA Surg. 2014; doi:10.1001/jamasurg.2014.1081.
Women with epithelial ovarian cancer who harbor BRCA mutations appear to be at low risk for developing breast cancer, according to results of a…
In the Journals

Adjuvant chemotherapy regimen safe, feasible for stage I nonseminomatous germ cell tumors

Vidal AD. Ann Oncol. 2014; doi:10.1093/annonc/mdu518.
Adjuvant treatment with one cycle of modified bleomycin, etoposide and cisplatin chemotherapy appeared safe and effective for patients with clinical…
In the Journals

Sunitinib appeared active in meningioma

Kaley TJ. Neuro Oncol. 2014;doi:10.1093/neuonc/nou148.
Sunitinib appeared effective in patients with recurrent atypical and malignant meningioma, according to results of a prospective, multicenter, phase…
In the Journals

ST2 levels predicted acute GVHD, mortality after double-unit cord blood transplantation

Ponce DM. Blood. 2014;doi:10.1182/blood-2014-06-584789.
High levels of the biomarker suppressor of tumorigenicity 2 at 28 days post-cord blood transplantation independently predicted acute…
In the Journals

Addition of monoclonal antibody to reduced-intensity conditioning regimen effective in advanced B-cell lymphoma

Bouabdallah K. Ann Oncol. 2014;doi:10.1093/annonc/mdu503.
The addition of the CD20-directed monoclonal antibody 90Y-Ibritumomab tiuxetan to a reduced-intensity fludarabine-based conditioning regimen followed…
In the Journals

Ado-trastuzumab emtansine significantly extended OS in HER-2–positive breast cancer with CNS metastases

Krop IE. Ann Oncol. 2014;doi:10.1093/annonc/mdu486.
Patients with HER-2–positive advanced breast cancer treated with ado-trastuzumab emtansine experienced similar rates of central nervous system…
In the Journals

More studies urged in managing posttreatment fatigue in thyroid cancer

To J. Thyroid. 2014;doi:10.1089/thy.2014.0418.
A paucity of reliable trials exists to guide evidence-based management of posttreatment fatigue in thyroid cancer survivors, according to a…
In the Journals

Diagnostic lineage test differentiated independent primary NSCLC tumors from metastatic disease

Murphy SJ. J Clin Oncol. 2014;doi:10.1200/JCO.2014.56.7644.
An analysis of genomic rearrangements detected by a diagnostic lineage test helped determine whether multiple non–small cell lung cancer tumors…
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