EXPERT SUMMARIES of the top 30 journals in hematology & oncology
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Robotic-assisted cystectomy noninferior to open procedure

Parekh DJ, et al. Lancet. 2018;doi:10.1016/S0140-6736(18)30996-6.
Seiler R and Thalmann GN. Lancet. 2018;doi:10.1016/S0140-6736(18)31309-6.
Robotic-assisted cystectomy demonstrated comparable 2-year PFS to open cystectomy among patients with bladder cancer, according to phase 3 results…
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HPV-related oropharyngeal cancer incidence increasing among older adults

Chaturvedi AK and ZS Zumsteg. Cancer. 2018;doi:10.1002/cncr.31383.
Windon MJ, et al. Cancer. 2018;doi:10.1002/cncr.31385.
The median age of patients with HPV-related oropharyngeal squamous cell carcinoma increased since 1995, reflecting the increasing incidence among…
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High-dose steroids for treatment-induced hypophysitis reduce melanoma survival

Faje AT, et al. Cancer. 2018;doi:10.1002/cncr.31629.
Johnson DB. Cancer. 2018;doi:10.1002/cncr.31627.
High-dose glucocorticoid therapy failed to benefit patients with melanoma who developed hypophysitis following treatment with ipilimumab, according…
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Diabetes increases risk for all cancers by 10%

Ohkuma T, et al. Diabetologia. 2018;doi:10.1007/s00125-018-4664-5.
Adults with diabetes have a 10% greater risk for developing any cancer vs. those without diabetes, whereas the disease confers a greater risk for…
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Study assesses clinical impact of linezolid-resistant S. epidermidis in leukemia patients

Aitken SL, et al. Open Forum Infect Dis. 2018;doi:10.1093/ofid/ofy167.
Li X, et al. Clin Infect Dis. 2018;doi: 10.1093/cid/ciy089.
Patients with leukemia who have linezolid-resistant Staphylococcus epidermidis and are treated with linezolid are significantly more likely to have…
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Diet soft drinks linked to reduced colon cancer recurrence, mortality

Guercio BJ, et al. PLoS One. 2018;doi:10.1371/journal.pone.0199244.
Patients with advanced colon cancer who drank artificially sweetened soft drinks had a reduced risk for recurrence and cancer-specific mortality…
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High-dose vitamin D may not prevent cancer

Scragg R, et al. JAMA Oncol. 2018;doi:10.1001/jamaoncol.2018.2178.
Individuals who received monthly high concentrations of vitamin D without calcium did not appear to have lower risk for cancer, according to findings…
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Use of complementary medicine linked to greater risk for cancer death

Johnson SB, et al. JAMA Oncol. 2018;doi:10.1001/jamaoncol.2018.2487.
The use of complementary medicine for the treatment of lung, breast, prostate or colorectal cancer appeared associated with refusal of conventional…
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Patients with head, neck cancers at excess risk for second primary malignant neoplasms

Boakye EA, et al. JAMA Otolaryngol Head Neck Surg. 2018;doi:10.1001/jamaoto.2018.0993.
Patients with head and neck squamous cell carcinoma appeared at increased risk for second primary malignant neoplasms, according to a…
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L-glutamine reduces painful crises associated with sickle cell disease

Minniti CP. N Engl J Med. 2018;doi:10.1056/NEJMe1800976.
Niihara Y, et al. N Engl J Med. 2018;doi:10.1056/NEJMoa1715971.
Adults and children with sickle cell disease who received prescription-grade oral L-glutamine alone or with hydroxyurea experienced fewer painful…
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Adverse skin reactions can occur months after anti-PD-1 treatment

Wang LL, et al. JAMA Dermatol. 2018;doi:10.1001/jamadermatol.2018.1912.
Adverse skin reactions to anti-PD-1 therapy for cancer treatment can occur months after therapy initiation and even after patients discontinue…
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Early dinner associated with reduced risk for prostate, breast cancer

Kogevinas M, et al. Int J Cancer. 2018;doi:10.1002/ijc.31649.
People who ate their evening meal before 9 p.m. or left a 2-hour window between eating dinner and going to bed had a 20% lower risk for breast or…
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‘Simple’ model predicts risk for cancer-related venous thromboembolism

Khorana AA. Lancet Haematol. 2018;doi:10.1016/S2352-3026(18)30067-X.
Pabinger I, et al. Lancet Haematol. 2018;doi:10.1016/S2352-3026(18)30063-2.
A clinical prediction model that used tumor-site category and D-dimer as the only variables accurately predicted risk for venous thromboembolism…
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HPV status of head, neck cancer influences fatigue, inflammation

Xiao C, et al. Cancer. 2018;doi:10.1002/cncr.31537.
Patients with HPV-unrelated squamous cell carcinoma of the head and neck experienced greater fatigue and inflammation at baseline and over time than…
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Treatment-related amenorrhea incidence consistent among anti-HER-2 regimens

Cathcart-Rake E, et al. J Natl Cancer Inst. 2018;doi:10.1093/jnci/djy092.
Lambertini M, et al. J Natl Cancer Inst. 2018;doi:10.1093/jnci/djy094.
Treatment-related amenorrhea incidence appeared consistent among premenopausal women with hormone receptor-positive or HER-2-positive breast cancer…
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