HemOnc Today scans the TOP 30 JOURNALS to bring you the most important articles published in your field.
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End-of-life care 'suboptimal' in elderly patients with acute myeloid leukemia

Wang R, et al. J Clin Oncol. 2017;doi:10.1200/JCO.2017.72.7149.
End-of-life care suboptimal for elderly patients with acute myeloid leukemia, with increas use of hospice care occurring mostly in the last 7 days of…
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Ipatasertib shows promise for triple-negative breast cancer

Delaloge S and DeForceville L. Lancet Oncol. 2017;doi:10.1016/S1470-2045(17)30450-3.
Kim SB, et al. Lancet Oncol. 2017;doi:10.1016/S1470-2045(17)30450-3.
The addition of ipatasertib to paclitaxel improved PFS among women with triple-negative breast cancer, according to results from the LOTUS trial…
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Melanoma immunotherapy trials may not capture all toxicity data

Shoushtari AN, et al. JAMA Oncol. 2017;doi:10.1001/jamaoncol.2017.2391.
Common Terminology Criteria for Adverse Events may not appropriately reflect immune-related adverse event severity, duration or timing, according to…
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HPV behind nearly 75% of oropharyngeal cancer cases in Canada

Habbous S, et al. CMAJ. 2017;doi:10.1503/cmaj.161379.
The proportion of oropharyngeal cancers associated with HPV in several cancer centers across Canada rose from nearly half to nearly three-quarters…
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Fusions define new colorectal cancer subtype with poor prognosis

Pietrantonio F, et al. JNCI J Natl Cancer Inst. 2017;doi:10.1093/jnci/djx089.
Patients with ALK-, ROS1- or NTRK-rearranged tumors defined a rare subtype in metastatic colorectal cancer associated with poor outcomes, according…
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Vorinostat may prevent graft-versus-host disease after unrelated donor bone marrow transplant

Choi SW, et al. Blood. 2017;doi:10.1182/blood-2017-06-790469.
Vorinostat appeared safe and effective combined with standard graft-versus-host disease prophylaxis for patients undergoing matched unrelated donor…
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CAR T-cell therapy effective for chronic lymphocytic leukemia

Turtle CJ, et al. J Clin Oncol. 2017;doi:10.1200/JCO.2017.72.8519.
CD19-specific chimeric antigen receptor-modified T-cell therapy induced durable molecular remissions in patients with high-risk chronic lymphocytic…
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Liquid biopsy offers option for EGFR testing without lung tumor tissue

Mayo-de-las-Casas C, et al. Ann Oncol. 2017;doi:10.1093/annonc/mdx288.
Blood assays identified EGFR mutations in patients with advanced non-small cell lung cancer with insufficient tumor biopsies, according to a…
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Older patients with cancer may burden caregivers by overestimating physical abilities

Hsu T, et al. Oncologist. 2017;doi:10.1634/theoncologist.2017-0085.
Older patients with cancer often reported having better physical function, mental health and social support than their caregivers’ assessments…
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ASCO updates guideline on systemic therapy for non-small cell lung cancer

Hanna N, et al. J Clin Oncol. 2017;doi:10.1200/JCO.2017.74.6065.  
An updated ASCO clinical practice guideline clarifies the appropriate use of immunotherapy and provides new recommendations on the use of targeted…
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Adolescents who distrust cancer care for a dying parent likely to face psychological problems

Beernaert K, et al. J Clin Oncol. 2017;doi:10.1200/JCO.2017.72.9814.
Adults who did not trust health care professionals after losing a parent to cancer during adolescence had a higher risk for negative long-term…
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Venous thromboembolic events persist despite in-hospital prophylaxis

Heit JA, et al. Blood. 2017.doi:10.1182/blood-2016-12-758995.
Near-universal in-hospital prophylaxis did not lead to declines in hospital-related venous thromboembolic events, according to a study published in…
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HER-2 mutation found in advanced lung cancer

Pillai RN, et al. Cancer. 2017;doi:10.1002/cncr.30869.
Nearly 3% of patients with advanced lung adenocarcinoma tested positive for the HER-2 gene, the common driver mutation for breast cancer, according…
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Low-risk thyroid cancer may respond to less aggressive treatments

Robenshtok E, et al. Thyroid. 2017;doi:10.1089/thy.2017.0040.
Adults with low-risk differentiated thyroid cancer may be at lower risk for disease-related mortality compared with those with intermediate- and…
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Breast cancer outcomes for young women who choose conservative treatment improve over time

Botteri E, et al. Br J Surg. 2017;doi:10.1002/bjs.10658.
Outcomes for young women with breast cancer who underwent conservative treatment improved significantly over time, according to results of a…

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