Modules
Modules
The Immune System
The Immune System
Overview/Key Objectives
The Immune System
Components of the Immune System
The Innate vs. Adaptive Immune Response
Inflammation
Adaptive Immunity – Humoral and Cellular Immunity
Activated vs. Anergic Immune Functionality
References
Assessment Questions
Cancer and the Immune System: History and Theory
Cancer and the Immune System: History and Theory
Overview/Key Objectives
Brief History of Cancer Immunotherapy Approaches and Theories
A Hallmark of Cancer – Evasion of Immune Destruction
Immuno-oncology Theories – Immunoediting and Immune Surveillance
Cancer-Immunity Cycle
References
Assessment Questions
Clinical Indications
Clinical Indications
Overview/Key Objectives
Breast Cancer
Melanoma
Colorectal Cancer
Gastric/Gastroesophageal Junction Cancer
Lung Cancer
Bladder Cancer
Kidney Cancer
Prostate Cancer
Cervical Cancer
B-Cell Non-Hodgkin Lymphoma
Classical Hodgkin Lymphoma
Acute Lymphoblastic Leukemia
Anaplastic Large-Cell Lymphoma
Multiple Myeloma
Merkel Cell Carcinoma
Summary
References
Assessment Questions
Immune System Signaling Pathways
Immune System Signaling Pathways
Overview/Key Objectives
T Cell Signaling
Natural Killer Cell Signaling
B7 Family of Ligands
Inflammation
Inhibitory Signaling Pathways
References
Assessment Questions
Immunotherapies
Immunotherapies
Overview/Key Objectives
Non-targeted (Non-specific) Immunotherapies
Targeted Immunotherapies: Monoclonal Antibodies, Checkpoint Inhibitors, Therapeutic Vaccines
Targeted Immunotherapies: Adoptive Cell Therapies, Oncolytic Virus Therapy
Single vs. Combination Immunotherapies
References
Immunotherapy: Adverse Events
Immunotherapy: Adverse Events
Overview/Key Objectives
Cardiovascular
Dermatologic
Endocrine
Endocrine cont
Gastrointestinal
Cardiovascular
Pulmonary
Renal
Cardiovascular
Neurologic Conditions
Summary
References
Assessment Questions
Adverse Events
Adverse Events
Overview/Key Objectives
Rituximab
Trastuzumab
Alemtuzumab
Ibritumomab Tiuxetan
Cetuximab
Bevacizumab
Panitumumab
Recombinant HPV vaccines
Ofatumumab
Sipuleucel-T
Peginterferon alfa-2b
Ipilimumab
Brentuximab vedotin
Pertuzumab
Ado-trastuzumab emtansine
Obinutuzumab
Blinatumomab
Nivolumab
Pembrolizumab
Ramucirumab
Talimogene laherparepvec
Daratumumab
Elotuzumab
Atezolizumab
References
Assessment Questions
Quizzes
Tumor Boards
Videos
About
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Modules
The Immune System
Overview/Key Objectives
The Immune System
Components of the Immune System
The Innate vs. Adaptive Immune Response
Inflammation
Adaptive Immunity – Humoral and Cellular Immunity
Activated vs. Anergic Immune Functionality
References
Assessment Questions
Cancer and the Immune System: History and Theory
Overview/Key Objectives
Brief History of Cancer Immunotherapy Approaches and Theories
A Hallmark of Cancer – Evasion of Immune Destruction
Immuno-oncology Theories – Immunoediting and Immune Surveillance
Cancer-Immunity Cycle
References
Assessment Questions
Clinical Indications
Overview/Key Objectives
Breast Cancer
Melanoma
Colorectal Cancer
Gastric/Gastroesophageal Junction Cancer
Lung Cancer
Bladder Cancer
Kidney Cancer
Prostate Cancer
Cervical Cancer
B-Cell Non-Hodgkin Lymphoma
Classical Hodgkin Lymphoma
Acute Lymphoblastic Leukemia
Anaplastic Large-Cell Lymphoma
Multiple Myeloma
Merkel Cell Carcinoma
Summary
References
Assessment Questions
Immune System Signaling Pathways
Overview/Key Objectives
T Cell Signaling
Natural Killer Cell Signaling
B7 Family of Ligands
Inflammation
Inhibitory Signaling Pathways
References
Assessment Questions
Adverse Events
Overview/Key Objectives
Rituximab
Trastuzumab
Alemtuzumab
Ibritumomab Tiuxetan
Cetuximab
Bevacizumab
Panitumumab
Recombinant HPV vaccines
Ofatumumab
Sipuleucel-T
Peginterferon alfa-2b
Ipilimumab
Brentuximab vedotin
Pertuzumab
Ado-trastuzumab emtansine
Obinutuzumab
Blinatumomab
Nivolumab
Pembrolizumab
Ramucirumab
Talimogene laherparepvec
Daratumumab
Elotuzumab
Atezolizumab
References
Assessment Questions
Quizzes
Tumor Boards
Videos
About
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Hematology/Oncology
Learn Immuno-Oncology
The Immune System
The Immune System
Module Content
Overview/Key Objectives
The Immune System
Components of the Immune System
The Innate vs. Adaptive Immune Response
Inflammation
Adaptive Immunity – Humoral and Cellular Immunity
Activated vs. Anergic Immune Functionality
References
Assessment Questions
Overview/Key Objectives
The Immune System
Components of the Immune System
The Innate vs. Adaptive Immune Response
Inflammation
Adaptive Immunity – Humoral and Cellular Immunity
Activated vs. Anergic Immune Functionality
References
Assessment Questions
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Your Module Progress
1.
The purpose of the human immune system is to defend the body against non-self pathogens.
Your Colleagues Responded
A. True
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B. False
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2.
The innate immune system is long lasting, highly specific, and is sustained by long term by memory T cells.
Your Colleagues Responded
A. True
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B. False. The adaptive immune system is long lasting, highly specific, and is sustained by long term by memory T cells. The innate immune system in the body’s first response to a pathogen. It is fast acting and short lived.
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3.
Clonal expansion involves a rapid generation of T cells and B cells.
Your Colleagues Responded
A. True
0%
B. False
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4.
T cells originate in the ____________ and travel to the _____________ to mature and differentiate.
Your Colleagues Responded
A. Thymus, bone marrow
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B. Bone marrow, thymus
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C. Bone marrow, spleen
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D. Lymph nodes, thymus
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5.
The purpose of inflammation is to:
Your Colleagues Responded
A. Generate new T and B lymphocytes
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B. Bring white blood cells to the damaged or injured area to initiate tissue repair
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C. Prevent monocytes from differentiating into macrophages
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D. Defend the body against leukocytes
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6.
Humoral (or antibody mediated immunity) deals with antigens from pathogens that are ____________ while cellular immunity occurs ____________.
Your Colleagues Responded
A. Circulating outside of the cell; within cells
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B. Within cells; circulating outside of the cell
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7.
The immune system consists only of lymphocytes that circulate throughout the body in the blood vessels.
Your Colleagues Responded
A. True
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B. False. The immune system consists of organs, tissues and cells.
0%
8.
The organs of the immune system include (select all that apply):
Your Colleagues Responded
A. Thymus
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B. Bone marrow
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C. Heart
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D. Mucous membranes
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E. Lungs
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F. Lymph nodes
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G. Spleen
0%
H. Skin
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I. Pancreas
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9.
______________ are cells that carry out an immune response or function. Examples include T and B lymphocytes.
Your Colleagues Responded
A. Effector cells
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B. Non-effector cells
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C. Antigen presenting cells
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D. Antibody presenting cells
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10.
In cancer and other diseases that affect the immune system, ___________ prevent the _________ of the ___________ cells.
Your Colleagues Responded
A. Effector cells; immunosuppression; non-effector
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B. Non-effector cells; immune activity; effector
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C. Effector cells; immune activity, non-effector cells
0%
D. T regulatory cells; immune activity; non-effector cells
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