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Urothelial bladder cancer

Virtual Molecular Tumor Board


Carolinas HealthCare System
Levine Cancer Institute
Prepared: 2/20/2017
Presented by: Dr. Earle Burgess
Patient: Urothelial bladder cancer

History -- Part 1


  • 65-year-old male presented with gross hematuria in 2013.
    • Cystoscopic evaluation identified a large bladder tumor on the right lateral/posterior wall.
    • August 2013: Transurethral resection of bladder tumor identified high grade papillary urothelial carcinoma with extensive lamina propria invasion and focal muscularis propria invasion.
    • Staging studies negative, diagnosed with clinical stage T2N0M0 urothelial carcinoma of the bladder with right hydronephrosis.
  • Received 4 cycles of neoadjuvant gemcitabine and cisplatin.
  • February 2014: Robotic assisted radical cystoprostatectomy and bilateral pelvic lymph node dissection with ileal conduit urinary diversion
    • Pathology - Residual high grade, urothelial carcinoma with lamina propria invasion present and negative margins – pathologic stage ypT1 pN0.
  • February 2015: Surveillance imaging identified right ureteral lesion, which was identified as urothelial carcinoma via ureteroscopic biopsy.