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Glioblastoma

Virtual Molecular Tumor Board


Levine Cancer Institute
Presented by: Dr. Ashley Sumrall
Patient: Glioblastoma

Initial Diagnosis and Treatment


A 46-year-old man presented to the ED in Mexico with a 6-week history of left-sided numbness and tingling, slurred speech and increasing facial weakness. He underwent a CT scan with and without contrast that demonstrated a right frontal parietal mass with vasogenic edema. He was placed on levetiracetam, and arrangements were made to have him transported back to the United States for neurosurgical evaluation.

  • December 2015: Frontal craniotomy with stereotactic volumetric resection of tumor using microsurgical technique
    • Unmethylated glioblastoma (WHO grade 4)
    • IDH1 and IDH2 negative
    • 1p/19q negative
    • Tissue sent for molecular testing
  • January 2016 to February 2016: Radiation therapy (60 Gy/30 fractions) with concurrent temozolomide (Temodar, Merck)
  • March 2016: Possible pseudoprogression noted
  • April 2016: Stable scan
  • May 2016: Initiate maintenance temozolomide, planned 6 to 12 cycles
  • October 2016: Progressive disease