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Metastatic breast cancer

Virtual Molecular Tumor Board


Atrium Health
Presented by: Dr. Julie Fisher
Patient: Metastatic breast cancer

Initial Diagnosis and Treatment


A 55-year-old Caucasian woman noted a palpable lump in her left breast in August 2008.

  • Diagnostic breast imaging revealed a 1.6 cm x 1.2 cm x 1.0 cm spiculated mass corresponding to the area of palpable concern
  • Ultrasound-guided core biopsy showed poorly differentiated invasive ductal carcinoma: ER+, PR+, HER-2-Neu 2+ by immunohistochemistry (equivocal) and negative by FISH (ratio: 1.46)
  • September 2008: Initiated dose-dense doxorubicin/cyclophosphamide
  • Patient was found to have metastasis to the lung and liver after two cycles