Modules
Modules
Genomics Primer
Genomics Primer
Overview/Key Objectives
What are Eukaryotic Cells?
DNA Definition
What are Chromosomes?
What is a Genome?
Regulation of Gene Expression in Eukaryotes
Genetic Alterations
References
Assessment Questions
Course Introduction
Course Introduction
Overview/Key Objectives
What is Precision Medicine?
Precision Medicine in the Clinic
Direct-to-Consumer Genomic Testing
Ongoing Genomic Research and Big Data in Precision Medicine
References
Assessment Questions
Pathology Assessment of Tumor Tissue
Pathology Assessment of Tumor Tissue
Overview/Key Objectives
Introduction to the Pathology Laboratory
Specimen Preparation
Initial Pathology Assessment
Common Pathology Tests Performed in Oncology
References
Assessment Questions
Introduction to Liquid Biopsies
Introduction to Liquid Biopsies
Overview/Key Objectives
What is a Liquid Biopsy?
Approaches to Liquid Biopsy Analysis: CTCs and cfDNA
Technologies for Isolation and Detection of CTCs and cfDNA
Liquid Biopsy Applications
Concordance Between Tumor and Liquid Biopsies for Mutational Analysis
Select Commercially Available Liquid Biopsy Assays
References
Assessment Questions
Lung Cancer: Assessment, Treatment
Lung Cancer: Assessment, Treatment
Introduction
Current Oncogenic Biomarkers in Lung Cancer
EGFR Epidermal Growth Factor
EGFR Exon 20 Insertions
EGFR Exon 18
ALK Anaplastic Lymphoma Kinase
ROS1 ROS Proto oncogene 1
BRAF v raf murine sarcoma viral oncogene homolog B
NTRK: Fusion Neurotrophic Tropomyosin Receptor Kinase
MET: Mesenchymal-to-Epithelial Transition
RET Fusion: Rearranged During Transfection
HER2: Human Epidermal Growth Factor 2
KRAS: Kirsten RAT Sarcoma Viral Oncogenic Homolog
References
NTRK3 Fusion
NTRK3 Fusion
Initial Diagnosis
Clinical Progress and Treatment
Imaging
Pathology Part 1
Pathology Part 2
Discussion and Proposed Potential Therapies
References
Whole-Genome Sequencing
Whole-Genome Sequencing
Overview/Key Objectives
What is Whole-Genome Sequencing?
Sanger Sequencing
Whole-Genome Sequencing Methods
Whole-Genome vs. Whole-Exome Sequencing vs. Targeted Sequencing Panels
Strengths and Limitations of Next-Generation Sequencing
Next-Generation Sequencing in the Research and Clinic Settings
Importance of Bioinformatics
References
Assessment Questions
Genomic Medicine in Clinical Practice: Era of Personalized Medicine
Genomic Medicine in Clinical Practice: Era of Personalized Medicine
Overview/Key Objectives
Clinical Settings for Genomic Testing
Considerations When Choosing a Genomic Testing Approach
Liquid Biopsies
Frequently Discussed Topics
Future of Genomic Medicine
References
Assessment Questions
Quizzes
Tumor Boards
Videos
About
Visit Healio.com
Modules
Genomics Primer
Overview/Key Objectives
What are Eukaryotic Cells?
DNA Definition
What are Chromosomes?
What is a Genome?
Regulation of Gene Expression in Eukaryotes
Genetic Alterations
References
Assessment Questions
Course Introduction
Overview/Key Objectives
What is Precision Medicine?
Precision Medicine in the Clinic
Direct-to-Consumer Genomic Testing
Ongoing Genomic Research and Big Data in Precision Medicine
References
Assessment Questions
Pathology Assessment of Tumor Tissue
Overview/Key Objectives
Introduction to the Pathology Laboratory
Specimen Preparation
Initial Pathology Assessment
Common Pathology Tests Performed in Oncology
References
Assessment Questions
Introduction to Liquid Biopsies
Overview/Key Objectives
What is a Liquid Biopsy?
Approaches to Liquid Biopsy Analysis: CTCs and cfDNA
Technologies for Isolation and Detection of CTCs and cfDNA
Liquid Biopsy Applications
Concordance Between Tumor and Liquid Biopsies for Mutational Analysis
Select Commercially Available Liquid Biopsy Assays
References
Assessment Questions
Lung Cancer: Assessment, Treatment
Introduction
Current Oncogenic Biomarkers in Lung Cancer
EGFR Epidermal Growth Factor
EGFR Exon 20 Insertions
EGFR Exon 18
ALK Anaplastic Lymphoma Kinase
ROS1 ROS Proto oncogene 1
BRAF v raf murine sarcoma viral oncogene homolog B
NTRK: Fusion Neurotrophic Tropomyosin Receptor Kinase
MET: Mesenchymal-to-Epithelial Transition
RET Fusion: Rearranged During Transfection
HER2: Human Epidermal Growth Factor 2
KRAS: Kirsten RAT Sarcoma Viral Oncogenic Homolog
References
Whole-Genome Sequencing
Overview/Key Objectives
What is Whole-Genome Sequencing?
Sanger Sequencing
Whole-Genome Sequencing Methods
Whole-Genome vs. Whole-Exome Sequencing vs. Targeted Sequencing Panels
Strengths and Limitations of Next-Generation Sequencing
Next-Generation Sequencing in the Research and Clinic Settings
Importance of Bioinformatics
References
Assessment Questions
Genomic Medicine in Clinical Practice: Era of Personalized Medicine
Overview/Key Objectives
Clinical Settings for Genomic Testing
Considerations When Choosing a Genomic Testing Approach
Liquid Biopsies
Frequently Discussed Topics
Future of Genomic Medicine
References
Assessment Questions
Quizzes
Tumor Boards
Videos
About
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Hematology/Oncology
Learn Genomics
Introduction to Liquid Biopsies
Pathology Assessment of Tumor Tissue
Module Content
Overview/Key Objectives
Introduction to the Pathology Laboratory
Specimen Preparation
Initial Pathology Assessment
Common Pathology Tests Performed in Oncology
References
Assessment Questions
Overview/Key Objectives
Introduction to the Pathology Laboratory
Specimen Preparation
Initial Pathology Assessment
Common Pathology Tests Performed in Oncology
References
Assessment Questions
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Your Module Progress
1.
Which of the following assays would be considered a form of liquid biopsy?
Your Colleagues Responded
A. Quantification of cell-free circulating DNA (cfDNA) in patient with lung cancer
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B. EGFR mutation testing in circulating tumor DNA (ctDNA) in patient with lung cancer
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C. Enumeration of circulating tumor cells (CTCs) in peripheral blood from patient with breast cancer
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D. All of the above
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2.
Cold ischemic time for tissue specimens being sent to the pathology lab is defined as:
Your Colleagues Responded
A. The duration of time the specimen is in refrigeration
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B. The duration of time between when a specimen is removed from a patient to when it is in contact with formalin
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C. The duration of time a specimen is in contact with formalin
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D. The duration of time a specimen is decalcified
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3.
An example of a predictive biomarker is:
Your Colleagues Responded
A. . CA19-9 level in pancreatic cancer
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B. Expression of CD44 in bladder cancer
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C. Detection of BRAF V600E mutation in melanoma
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D. Expression of cyclin D1 in bladder cancer
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4.
Which of the following pre-analytical factors may affect the antigenicity of tumor tissue used for immunohistochemistry testing?
Your Colleagues Responded
A. Decalcification of the specimen
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B. Under fixation of tissue prior to evaluation
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C. Prolonged cold ischemic time
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D. All of the above
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5.
Which of the following sequencing techniques employs a process similar to capillary electrophoresis?
Your Colleagues Responded
A. Sanger sequencing
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B. Pyrosequencing
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C. Next-generation sequencing
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D. None of the above
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