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Hydroxyurea appears safe for African children with sickle cell anemia

Hydroxyurea appears safe for African children with sickle cell anemia
October 19, 2017

Hydroxyurea did not increase the risk for malaria infection in children with sickle cell anemia who live in malaria-endemic regions of Uganda, according to the results of a randomized, double-blind clinical trial published in Blood.

“Hydroxyurea has proven laboratory and clinical efficacy for children and adults with sickle cell anemia living in the United States and Europe,” Russell E. Ware, MD, PhD, director of the division of hematology at Cincinnati Children’s Hospital Medical Center, told HemOnc Today. “However, there are virtually no data regarding its safety and toxicities in sub-Saharan Africa, which bears the greatest global burden of disease.”

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