In the Journals

Previous CIN3 diagnosis doubled cervical, vaginal cancer mortality risk

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February 19, 2014

Women previously treated for cervical intraepithelial neoplasia grade 3 were more than twice as likely to die from cervical or vaginal cancers than the general population, according to results of a population-based cohort study.

Researchers conducted the study to identify the factors that influenced long-term risks for the development of or mortality from invasive cervical or vaginal cancers.

The investigators reviewed the Swedish Cancer Registry and Swedish Cause of Death Register from 1958 to 2008. They identified 150,883 women diagnosed with cervical intraepithelial neoplasia grade 3 (CIN3) who were followed for invasive cervical or vaginal cancer, as well as related mortality. The analysis included 3.14 million person-years of follow-up.

Results showed women with a previous diagnosis of CIN3 were at more than double the risk for mortality from invasive cervical or vaginal cancer compared with the general population (standardized mortality ratio=2.35; 95% CI, 2.11-2.61).

In addition, women aged older than 60 years demonstrated an increased risk for developing invasive caner. The risk accelerated again after age 70.

“The risk of treated women contracting or dying from cervical or vaginal cancer increases considerably with older age,” the researchers wrote. “Attained age and age at treatment explain the increase in long-term risk. These findings might have important implications for management, because women treated for CIN grade 3 apparently need follow-up until old age.”

Disclosure: The researchers report no relevant financial disclosures.

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