Elevated intake of fat of animal origin, particularly
red meat and dairy, was associated with increased risk for pancreatic cancer,
according to the findings from a prospective study.
The study included 308,736 men and 216,737 women aged 50
to 71 from the NIH-AARP Diet and Health Study.
Participants completed a
124-item food frequency questionnaire during 1995 to 1996. During that time, the incident rate for exocrine
pancreatic cancer was 45.0 per 100,000 person-years for men and 34.5 per
100,000 person-years for women.
Men in the highest quintile of fat consumption had
a 53% higher incidence of pancreatic cancer than men in the lowest quintile and
women in the highest quintile had a 23% higher incidence of pancreatic cancer
than women in the lowest quintile, researchers said.
After adjustment, men and women in the highest quintile
of percent energy from fat had a higher risk for pancreatic cancer linked to
total fat consumption (46.8 vs. 33.2 cases per 100,000 person-years; HR=1.23;
95% CI, 1.03-1.46) than those in the lowest quintile.
Similar associations were observed with saturated fat
consumption (51.5 vs. 33.1; HR=1.36; 95% CI, 1.14-1.62) and monounsaturated fat
consumption (46.2 vs. 32.9; HR=1.22; 95% CI, 1.02-1.46). No association was
observed with polyunsaturated fat.
Overall, there was a 1.43 HR for the association between
saturated fat intake of animal origin and pancreatic cancer risk (95% CI,
1.20-1.70). Pancreatic cancer risk was linked to saturated fat intake from red
meat (HR=1.27; 95 % CI, 1.07-1.52) and dairy products (HR=1.19; 95% CI,
Thiebaut ACM. J Natl Cancer Inst.
More In the Journals summaries >>