XELOX improved DFS in patients of all ages with stage III colon cancer

2010 Gastrointestinal Cancers Symposium

Results from a subgroup analysis of the NO16968 trial showed that patients of all ages with stage III colon cancer had superior disease-free survival when assigned to a combination of capecitabine and oxaliplatin (XELOX) compared with those assigned to standard therapy with 5-FU and leucovorin.

Previous data had shown that older patients either did not benefit or could not tolerate combination therapy with 5-FU plus leucovorin and oxaliplatin.

“Based on these data, XELOX offers superior DFS benefits with therapy regardless of age,” said Daniel G. Haller, MD, professor of medicine and Deenie Greitzer Professor of Gastrointestinal Oncology at the Abramson Cancer Center at the University of Pennsylvania. He presented the results during a press conference in advance of the 2010 Gastrointestinal Cancers Symposium.

“Although the OS benefits are presently immature, there are trends for OS advantage in all examined groups, and there are many other data yet to be analyzed that will be presented over the next few years.”

Researchers randomly assigned 1,886 patients with stage III colon cancer to XELOX or 5-FU plus leucovorin. At three years, overall DFS was 71% for those assigned to XELOX vs. 67% for those assigned to 5-FU plus leucovorin.

For patients older than 70, DFS was 66% with XELOX vs. 60% with 5-FU and leucovorin (HR=0.87; 95% CI, 0.63-1.18). Three-year DFS for patients aged younger than 70 was 72% for those assigned to XELOX vs. 69% in the 5-FU and leucovorin group (HR=0.80; 95% CI, 0.65-0.98).

“In addition to the two other 5-FU/oxaliplatin regimens, XELOX offers an additional standard of care for stage III, node-positive colon cancer regardless of age with superior DFS benefits comparable to the established combination, and with expectations for survival benefit when patients are followed beyond six years,” Haller said.

He added that XELOX requires fewer office visits than other regimens and unlike FOLFOX regimens, XELOX does not require a surgically-implanted access device or infusion pump. – by Jason Harris

For more information:

  • Haller DG. #284. Presented at: the 2010 Gastrointestinal Cancers Symposium; Jan. 22-24, 2010; Orlando, Fla.

PERSPECTIVE

This is an interesting addition to the prior data on this chemotherapy regimen, indicating that it is effective in patients older than 70. Certainly, the numbers were very impressive and I believe this data represents an important addition to our current knowledge.

– Robert P. Sticca, MD
Chairman, Department of Surgery, University of North Dakota School of Medicine and Health Sciences

More Meeting Highlights>>


2010 Gastrointestinal Cancers Symposium

Results from a subgroup analysis of the NO16968 trial showed that patients of all ages with stage III colon cancer had superior disease-free survival when assigned to a combination of capecitabine and oxaliplatin (XELOX) compared with those assigned to standard therapy with 5-FU and leucovorin.

Previous data had shown that older patients either did not benefit or could not tolerate combination therapy with 5-FU plus leucovorin and oxaliplatin.

“Based on these data, XELOX offers superior DFS benefits with therapy regardless of age,” said Daniel G. Haller, MD, professor of medicine and Deenie Greitzer Professor of Gastrointestinal Oncology at the Abramson Cancer Center at the University of Pennsylvania. He presented the results during a press conference in advance of the 2010 Gastrointestinal Cancers Symposium.

“Although the OS benefits are presently immature, there are trends for OS advantage in all examined groups, and there are many other data yet to be analyzed that will be presented over the next few years.”

Researchers randomly assigned 1,886 patients with stage III colon cancer to XELOX or 5-FU plus leucovorin. At three years, overall DFS was 71% for those assigned to XELOX vs. 67% for those assigned to 5-FU plus leucovorin.

For patients older than 70, DFS was 66% with XELOX vs. 60% with 5-FU and leucovorin (HR=0.87; 95% CI, 0.63-1.18). Three-year DFS for patients aged younger than 70 was 72% for those assigned to XELOX vs. 69% in the 5-FU and leucovorin group (HR=0.80; 95% CI, 0.65-0.98).

“In addition to the two other 5-FU/oxaliplatin regimens, XELOX offers an additional standard of care for stage III, node-positive colon cancer regardless of age with superior DFS benefits comparable to the established combination, and with expectations for survival benefit when patients are followed beyond six years,” Haller said.

He added that XELOX requires fewer office visits than other regimens and unlike FOLFOX regimens, XELOX does not require a surgically-implanted access device or infusion pump. – by Jason Harris

For more information:

  • Haller DG. #284. Presented at: the 2010 Gastrointestinal Cancers Symposium; Jan. 22-24, 2010; Orlando, Fla.

PERSPECTIVE

This is an interesting addition to the prior data on this chemotherapy regimen, indicating that it is effective in patients older than 70. Certainly, the numbers were very impressive and I believe this data represents an important addition to our current knowledge.

– Robert P. Sticca, MD
Chairman, Department of Surgery, University of North Dakota School of Medicine and Health Sciences

More Meeting Highlights>>