Excluding skin cancer, lung cancer is the second most common cancer diagnosed in both men and women in the United States, after prostate cancer and breast cancer, respectively.1
Non-small cell lung cancer (NSCLC) is the most common form of lung cancer, accounting for approximately 85% of new cases of lung cancer diagnosed each year in the United States. Small cell lung cancer accounts for about 10% to 15%, and fewer than 5% of lung cancers are attributed to lung carcinoid tumors.2
An estimated 234,030 new cases of lung cancer will be reported in 2018.3
An estimated 154,050 people (83,550 men and 70,500 women) are expected to die from lung cancer in 2018, making it the leading cause of cancer death in men and women nationwide.1
Since 1990, the death rate from lung cancer has declined by 43% in men. Since 2002, the death rate has declined by 17% in women. These declining rates are attributed to reductions in smoking.3
The average age of patients at diagnosis is 70 years. Lung cancer is diagnosed in only a small number of people who are younger than age 45 years.1
- The 5-year relative survival rate of patients with lung and bronchus cancer (all stages combined) is 18%. For patients with localized cancer, the 5-year survival rate is 56%. The rate drops to 5% if the cancer has metastasized to distant sites.4
NSCLC rates among never-smokers have doubled over the last decade, with two-thirds of these cases occurring in women.5
About 5% of patients with NSCLC adenocarcinomas have ALK–positive lung cancer. These patients are younger than other patients with NSCLC and most are never-smokers.6
In the United States, about 21% to 23% of patients with NSCLC have EGFR–positive lung cancer, and the frequency of this mutation is higher in women than in men (28% vs. 19%) and higher in never-smokers than in ever-smokers (47% vs. 14%).7
In the United States, more than 750 lung cancer clinical trials are either actively recruiting or plan to recruit patients in the near future.8
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