ASTRO Annual Meeting
MIAMI - In patients with breast cancer who were treated with a regimen
of accelerated intensity modulated radiation therapy with a concurrent boost to
the tumor bed, the local control rate was 98.6% and the OS was 97.6%.
From 2003 to 2006, researchers, including Etin-Osa O. Osa, MD,
from the New York University Clinical Cancer Center, evaluated 490 patients
with stage 0, I or II breast cancer who were prospectively enrolled in two
consecutive protocols. The patients had received radiotherapy after a segmental
mastectomy and had negative margins of tumor excisions.
Accelerated intensity modulated radiation included a total dose of 40.5
Gy, delivered in 15 fractions at 2.7 Gy per fraction. The patients received
treatment Monday to Friday for 3 weeks, and received a concomitant daily boost
of 0.5 Gy to the tumor site. The majority of women, 93%, were treated in the
prone position, and the remaining 7% were treated in the supine position.
Most of the patients, 82%, had stage I or II invasive breast cancer and
18% had ductal carcinoma in situ. After a median follow-up of 3 years, seven
patients had a local recurrence, resulting in 98.6% local control. Five
additional patients developed distant recurrence and four others developed
contralateral breast cancer.
There were 12 total deaths, five of which were breast cancer-related,
resulting in a 97.6% OS. An evaluation of late radiation toxicity showed that
57% of the patients experience grade-1 toxicity, 18% experienced grade-2
toxicity, 3% experienced grade-3 toxicity and 22% had no toxicity. A self
evaluation of cosmesis showed that 83% of the patients reported a
good-excellent result, 16% a fair result and 1% a poor result.
Earn CME this spring at the HemOnc Today Breast Cancer Review & Perspective meeting to be held March 23-24, 2012 at the Hilton San Diego Bayfront. See details at HemOncTodayBreastCancer.com.
For more information:
- Osa EO. #17. Presented at: the 53rd ASTRO Annual Meeting; Oct. 2-6,
2011; Miami Beach, Fla.
Disclosure: Dr. Osa reports no relevant financial