Family history of breast cancer increased risk for contralateral breast cancer among younger women, even when those who had deleterious genetic mutations were excluded, according to study results.
“Compared with women without a family history, those with a positive family history have a two- to fourfold increased risk [for] developing breast cancer, which depends on the number of affected relatives and their ages at diagnosis,” Anne S. Reiner, MPH, senior research biostatistician at Memorial Sloan Kettering Cancer Center, and colleagues wrote. “The Women’s Environmental Cancer and Radiation Epidemiology (WECARE) Study is a population-based, case-control study of contralateral breast cancer cases and matched controls with unilateral breast cancer. ... The completion of the second phase of WECARE allows us to clarify the relationship between family history of breast cancer and contralateral breast cancer risk.”
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