Recently published studies have demonstrated new developments in colorectal cancer.
In case you missed it, the editors of Healio Gastroenterology and Liver Disease have compiled a recap of some of the most recent developments in the world of colorectal cancer, including a new risk model, artificial intelligence-assisted polyp detection and racial disparities in screening rates.
High-, low-risk adenomas could inform colonoscopy intervals
The presence of high- or low-risk adenomas at screening colonoscopy could help physicians determine how long to make surveillance intervals, according to study results.“Ideally, surveillance recommendations are based on the risk of developing and dying from colorectal cancer after adenoma removal,” Jeffrey K. Lee, MD, MAS, of the department of gastroenterology at Kaiser Permanente San Francisco, and colleagues wrote. “Yet most studies that serve as the basis for the guidelines have either been small in size, performed under highly standardized conditions or with selected populations, lacked long-term follow-up and colonoscopy quality data, evaluated broad time intervals, or focused on advanced adenomas rather than colorectal cancer incidence and mortality as the primary outcome.” READ MORE
Colorectal cancer risk model could optimize colonoscopy resources
Researchers from Poland developed a risk classification model that could reduce the number of individuals who would be classified as high-risk for colorectal cancer after colonoscopy screening.
Paulina Wieszczy , MSc, of the department of gastroenterology, hepatology and clinical oncology at the Centre of Postgraduate Medical Education in Poland, and colleagues wrote that their new model could reduce the burden of surveillance colonoscopies without increasing the risk for CRC in patients with adenomas. READ MORE
AI system improves colorectal neoplasm detection
An artificial intelligence-assisted system improved the identification of colorectal neoplasms, according to findings from a study published in Clinical Gastroenterology and Hepatology.
“Computer-aided diagnosis of endoscopic images using artificial intelligence has attracted attention because of its potential for better accuracy and lower interobserver variability,” Shin-ei Kudo, from the Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan, and colleagues wrote. “With [computer-aided] technology, non-expert endoscopists may more easily achieve accuracy levels sufficient to meet the PIVI threshold.” READ MORE
CRC risk with family history lower than previous estimates
Patients with first-degree family members who have been diagnosed with colorectal cancer are at lower risk than previously estimated for developing the disease themselves, according to recent study results.
“According to various clinical practice guidelines, individuals with [familial CRC] are recommended to undergo more intensive surveillance strategies than the general population, starting at an earlier age,” Rodrigo Jover, MD, PhD, of the department of gastroenterology at Hospital General Universitario de Alicante in Spain, and colleagues wrote. “However, the definition of who should undergo intensified colonoscopy surveillance instead of average-risk screening varies widely.” READ MORE
Q&A: Addressing racial disparities in colorectal cancer screening
Screening rates for colorectal cancer have increased over the last decade, according to data published in Clinical Gastroenterology and Hepatology. However, researchers found that despite this uptick, disparities in screening rates persist among racial and ethnic minority groups.
Study author Folasade (Fola) P. May, MD, PhD, of the Tamar and Vatche Manoukin Division of Digestive Diseases at the University of California, Los Angeles, provided Healio Gastroenterology and Liver Disease with some insight into the study, highlighted some of the issues driving the disparity and offered some potential strategies to help bridge the gap. READ MORE