Oncology

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Companies collaborate to evaluate immunotherapy regimen for colorectal cancer

June 22, 2017

Three companies — eFFECTOR Therapeutics, Pfizer and Merck KGaA — entered a clinical collaboration to evaluate the combination of eFT508 and avelumab for patients with microsatellite stable colorectal cancer.

eFT508 (eFFECTOR Therapeutics) is a highly selective oral inhibitor of MNK1/2 kinases that mediate tumor immune evasion and are activated downstream of MEK and MAPK signaling.

In the Journals

Extensive preop chemo for colorectal liver metastases linked to hepatic atrophy

June 22, 2017
Results of a recently published study showed an association between extensive preoperative chemotherapy in patients with colorectal liver metastases and hepatic atrophy…
In the Journals

Colorectal cancer task force ranks screening tests, suggests earlier screening in blacks

June 21, 2017
The U.S. Multi-Society Task Force on Colorectal Cancer Screening has released new recommendations that rank screening options for average-risk individuals, acknowledge…
In the Journals

Early decompensation predicts mortality in successfully treated HCC

June 21, 2017
The most significant risk factor for mortality in patients with hepatitis C-related cirrhosis and successfully treated hepatocellular carcinoma was hepatic…
CME Video

Loss of Response in the Treatment of Crohns Disease: A Case Study

This activity is supported by an educational grant from Receptos.

Anti-TNF agents are effective for inducing and maintaining remission in patients with Crohn's disease. However, a…
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GI Bookshelf

Chapter 5: Bowel Obstruction And Pseudo-Obstruction

From GI Emergencies: A Quick Reference Guide
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Digestive Disease Week

Digestive Disease Week

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VIDEO: Moffitt Cancer Center physician reviews how patients may reduce their risk for colon cancer

June 23, 2016
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Companies collaborate to evaluate immunotherapy regimen for colorectal cancer

June 22, 2017
Three companies — eFFECTOR Therapeutics, Pfizer and Merck KGaA — entered a clinical collaboration to evaluate the combination of eFT508…

In the Journals

Extensive preop chemo for colorectal liver metastases linked to hepatic atrophy

June 22, 2017
Results of a recently published study showed an association between extensive preoperative chemotherapy in patients with colorectal liver metastases…

In the Journals

Colorectal cancer task force ranks screening tests, suggests earlier screening in blacks

June 21, 2017
The U.S. Multi-Society Task Force on Colorectal Cancer Screening has released new recommendations that rank screening options for average-risk…

In the Journals

Early decompensation predicts mortality in successfully treated HCC

June 21, 2017
The most significant risk factor for mortality in patients with hepatitis C-related cirrhosis and successfully treated hepatocellular carcinoma was…

FDA News

FDA grants orphan drug designation to IT-139 for pancreatic cancer

June 20, 2017
The FDA granted orphan drug designation to IT-139 for the treatment of pancreatic cancer, according to the drug’s manufacturer. “IT-139…

In the Journals Plus

First-line cetuximab, bevacizumab show similar outcomes in colorectal cancer

June 20, 2017
The addition of cetuximab or bevacizumab to a first-line chemotherapy regimen demonstrated similar OS, PFS and response rates in patients with…

In the Journals

Fecal immunochemical test may be viable screening option for colorectal cancer

June 19, 2017
Fecal immunochemical testing for colorectal cancer demonstrated high overall diagnostic accuracy indicating it as a viable, safe, simple, low-cost…

Curbside Consultation

EUS Utility Varies Among Gastrointestinal Cancers

Healio Gastroenterology, June 2017
Thomas J. Savides, MD
A: Gastrointestinal endoscopic ultrasound (EUS) is an important tool for cancer staging because many treatment algorithms are determined by EUS tumor…

In the Journals Plus

Treatment improves OS in elderly patients with early-stage esophageal cancer

June 15, 2017
Elderly patients with early-stage esophageal cancer who received treatment achieved 5-year OS more often than those under observation, according to a…

In the Journals

CT, MRI pelvic scans result in limited new findings in patients with HCC

June 15, 2017
Computerized tomography and magnetic resonance imaging pelvic scans resulted in limited new findings of lesions or metastatic disease in patients…

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