August 18, 2017
Samsca, also known as tolvaptan, was safe when combined with conventional diuretics and presented promising results in treating patients with difficult-to-treat cirrhotic ascites, according to results of a recent prospective study. Blood urea nitrogen was a favorable marker for selecting patients most likely to respond to treatment.
“The main differences between tolvaptan and conventional diuretics are that tolvaptan does not stimulate the sodium channel and increases free water excretion without affecting urinary sodium and potassium excretion,” Hideto Kawaratani, MD, PhD, from the Nara Medical University, Japan, and colleagues wrote. “This mechanism seems to reduce the occurrence of diuretic-induced electrolyte abnormalities or renal failure.”