7 recent developments in Crohn's disease

Crohn’s disease has been a hot topic recently, with an abundance of data being published in the journals this month. Here is a recap of the most trafficked news on Healio Gastroenterology about Crohn’s disease.

 

1. Racial disparities exist among children with Crohn’s disease 

Jennifer Dotson

Disparities in hospital readmissions, complications and procedures in pediatric Crohn’s disease patients are related to race, according to data from a recent retrospective review.

“We found racial inequalities exist among children and adolescents with Crohn’s disease, likely due to a combination of genetic and environmental differences,” Jennifer Dotson, MD, MPH, a gastroenterologist at Nationwide Children’s Hospital in Columbus, Ohio, and principal investigator in the Center for Innovation and Pediatric Practice, said in a press release. “This is one of the first studies to investigate the rate of various health disparities in the Crohn’s disease population in pediatrics, despite the fact that 25% of the time, Crohn’s disease is diagnosed in childhood.” Read more

 

2. Experts release international consensus statement on surveillance, management of dysplasia in inflammatory bowel disease 

Tonya Kaltenbach

SCENIC, an international multidisciplinary group, has developed unifying consensus recommendations on surveillance and management of dysplasia in IBD.

“We recognized that there was variable practice in the surveillance methods for dysplasia detection in patients with IBD and there were also variable guidelines, both within the US and internationally,” Tonya Kaltenbach, MD, MS, from the Veterans Affairs Palo Alto, who served on the panel, told Healio Gastroenterology. The need for an international consensus statement, she said, came from “an interest to provide a uniform recommendation” — namely on the use of chromoendoscopy for the detection of dysplasia. Read more

 

3. CRP, calprotectin, excludes IBD in patients with IBS symptoms 

William D. Chey

Adding C-reactive protein and fecal calprotectin to symptom-based diagnostic criteria may help to rule out inflammatory bowel disease in patients with symptoms of irritable bowel syndrome, according to new research data.

“Though IBD is uncommon in patients with typical IBS symptoms and no alarming features, patients and providers remain concerned about this possibility,” William D. Chey, MD, AGAF, FACG, FACP, from the University of Michigan Health System, told Healio Gastroenterology. Read more

 

4. Slow IBD diagnosis in children leads to more advanced disease 

Slow diagnosis of inflammatory bowel disease in pediatric patients was associated with advanced bowel involvement at the time of diagnosis, according to recent data.

“Time from symptom onset to diagnosis for IBD among children and adolescents is too long: an average of 4 to 6 months,” the researchers wrote. “The majority of pediatric IBD patients already have extensive involvement at diagnosis.” Read more

 

5. FMT induces remission in pediatric patients with Crohn’s disease 

David L. Suskind

Children with Crohn’s disease achieved remission after fecal microbiota transplant, recent study data found.

“The fecal microbiome is likely the cause or trigger of the immune response in IBD,” David L. Suskind, MD, from the department of pediatrics, division of gastroenterology at Seattle Children’s Hospital, told Healio Gastroenterology. “Therapies which affect the fecal microbiome such as FMT, have the potential to change our current treatment paradigm by altering the fecal microbiome instead of using medications which suppress the immune response.” Read more

 

6. Smoking cessation programs for Crohn’s improve outcomes, reduce costs 

Stephanie Coward

Gilaad G. Kaplan

The integration of smoking cessation programs targeting patients with Crohn’s disease is cost-effective for health care systems, recent study data found.

“Smoking is known to worsen the course of Crohn’s disease, whereas individuals who quit have a similar prognosis to patients with Crohn’s disease who never smoked,” Stephanie Coward, MSc, and Gilaad G. Kaplan, MD, MPH, both from the University of Calgary in Alberta, Canada, told Healio Gastroenterology. “We conducted a cost-utility analysis to compare different smoking cessation strategies for patients with Crohn’s disease.” Read more

 

7. Mongersen appears to improve remission in Crohn’s disease

Séverine Vermeire

Patients with Crohn’s disease achieved remission and clinical response in greater proportions with mongersen, a novel oral SMAD7 antisense oligonucleotide, compared with placebo, according to recent study data. 

“The impressive clinical effects of mongersen beg for follow-up studies to confirm that we have indeed entered a new phase of Crohn’s disease treatment,” Séverine Vermeire, MD, PhD, from the University Hospitals in Leuven, Belgium, wrote in an accompanying editorial. Read more


Crohn’s disease has been a hot topic recently, with an abundance of data being published in the journals this month. Here is a recap of the most trafficked news on Healio Gastroenterology about Crohn’s disease.

 

1. Racial disparities exist among children with Crohn’s disease 

Jennifer Dotson

Disparities in hospital readmissions, complications and procedures in pediatric Crohn’s disease patients are related to race, according to data from a recent retrospective review.

“We found racial inequalities exist among children and adolescents with Crohn’s disease, likely due to a combination of genetic and environmental differences,” Jennifer Dotson, MD, MPH, a gastroenterologist at Nationwide Children’s Hospital in Columbus, Ohio, and principal investigator in the Center for Innovation and Pediatric Practice, said in a press release. “This is one of the first studies to investigate the rate of various health disparities in the Crohn’s disease population in pediatrics, despite the fact that 25% of the time, Crohn’s disease is diagnosed in childhood.” Read more

 

2. Experts release international consensus statement on surveillance, management of dysplasia in inflammatory bowel disease 

Tonya Kaltenbach

SCENIC, an international multidisciplinary group, has developed unifying consensus recommendations on surveillance and management of dysplasia in IBD.

“We recognized that there was variable practice in the surveillance methods for dysplasia detection in patients with IBD and there were also variable guidelines, both within the US and internationally,” Tonya Kaltenbach, MD, MS, from the Veterans Affairs Palo Alto, who served on the panel, told Healio Gastroenterology. The need for an international consensus statement, she said, came from “an interest to provide a uniform recommendation” — namely on the use of chromoendoscopy for the detection of dysplasia. Read more

 

3. CRP, calprotectin, excludes IBD in patients with IBS symptoms 

William D. Chey

Adding C-reactive protein and fecal calprotectin to symptom-based diagnostic criteria may help to rule out inflammatory bowel disease in patients with symptoms of irritable bowel syndrome, according to new research data.

“Though IBD is uncommon in patients with typical IBS symptoms and no alarming features, patients and providers remain concerned about this possibility,” William D. Chey, MD, AGAF, FACG, FACP, from the University of Michigan Health System, told Healio Gastroenterology. Read more

 

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4. Slow IBD diagnosis in children leads to more advanced disease 

Slow diagnosis of inflammatory bowel disease in pediatric patients was associated with advanced bowel involvement at the time of diagnosis, according to recent data.

“Time from symptom onset to diagnosis for IBD among children and adolescents is too long: an average of 4 to 6 months,” the researchers wrote. “The majority of pediatric IBD patients already have extensive involvement at diagnosis.” Read more

 

5. FMT induces remission in pediatric patients with Crohn’s disease 

David L. Suskind

Children with Crohn’s disease achieved remission after fecal microbiota transplant, recent study data found.

“The fecal microbiome is likely the cause or trigger of the immune response in IBD,” David L. Suskind, MD, from the department of pediatrics, division of gastroenterology at Seattle Children’s Hospital, told Healio Gastroenterology. “Therapies which affect the fecal microbiome such as FMT, have the potential to change our current treatment paradigm by altering the fecal microbiome instead of using medications which suppress the immune response.” Read more

 

6. Smoking cessation programs for Crohn’s improve outcomes, reduce costs 

Stephanie Coward

Gilaad G. Kaplan

The integration of smoking cessation programs targeting patients with Crohn’s disease is cost-effective for health care systems, recent study data found.

“Smoking is known to worsen the course of Crohn’s disease, whereas individuals who quit have a similar prognosis to patients with Crohn’s disease who never smoked,” Stephanie Coward, MSc, and Gilaad G. Kaplan, MD, MPH, both from the University of Calgary in Alberta, Canada, told Healio Gastroenterology. “We conducted a cost-utility analysis to compare different smoking cessation strategies for patients with Crohn’s disease.” Read more

 

7. Mongersen appears to improve remission in Crohn’s disease

Séverine Vermeire

Patients with Crohn’s disease achieved remission and clinical response in greater proportions with mongersen, a novel oral SMAD7 antisense oligonucleotide, compared with placebo, according to recent study data. 

“The impressive clinical effects of mongersen beg for follow-up studies to confirm that we have indeed entered a new phase of Crohn’s disease treatment,” Séverine Vermeire, MD, PhD, from the University Hospitals in Leuven, Belgium, wrote in an accompanying editorial. Read more


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