Women who used intermittent relievers to manage their asthma were more likely to have problems conceiving, according to data recently published in the European Respiratory Journal.
“While maternal asthma has been consistently associated with significant perinatal morbidities and mortality impacts on fertility are conflicting,” Luke E. Grzeskowiak, an Early Career Fellow at Adelaide Medical School, University of Adelaide in Australia, and colleagues wrote. “In light of limited and conflicting evidence, the aim of this study was to examine the impact of asthma and asthma medication use on fecundability and time to pregnancy.”
Researchers analyzed asthma status and medications; medical, family and gynecological history; and other demographic and physical characteristics of 5,617 participants of the Screening for Pregnancy Endpoints (SCOPE) study. Paternal BMI and age were also recorded. Women who had doctor-diagnosed asthma (n = 1,106) were further divided based on medication taken.
Grzeskowiak and colleagues found that women who currently have asthma managed by short-acting -agonists had adjusted fecundability ORs that were 15% lower (0.85; 95% CI, 0.75–0.96) vs. women without asthma. In addition, there was no difference in fecundability ORs seen in women currently with asthma who took inhaled corticosteroids ± long-acting -agonists (0.98; 95% CI 0.84–1.15) or women who used to have asthma (1; 95% CI, 0.89–1.13).
Also vs. patients without asthma, subfertility point estimates were higher in women utilizing short-acting -agonists (adjusted OR = 1.3; 95% CI, 0.93–1.81) but not in women who had asthma and took inhaled corticosteroids ± long-acting -agonists (adjusted OR = 1.08; 95% CI, 0.69–1.71) or in women who used to have asthma (adjusted OR = 0.89; 95% CI, 0.62–1.28).
“These findings support appropriate management of asthma with [inhaled corticosteroid] preventer medications to ensure optimal asthma control,” Grzeskowiak and colleagues wrote. “Women with asthma planning a pregnancy should be encouraged to continue taking their preventer medications.” – by Janel Miller
The authors report no relevant financial disclosures.