July 25, 2017
Researchers observed a bidirectional relationship between vasomotor symptoms, or VMS, and depressive symptoms in menopausal women, but VMS are not related to the first onset of major depressive disorder in the menopausal transition, according to a meta-analysis of 16 studies published in Menopause.
“It is plausible that there is a bidirectional relationship between VMS and depression during the menopausal transition,” Rifani B. Natari, MSc, of the School of Pharmacy at The University of Queensland in Australia, and colleagues wrote. “VMS share similar physiological process with depression during this period. Change in neurotransmitter levels in the brain, due to estrogen depletion, narrows the thermoneutral zone in the brain, hence disrupting the thermoregulation process leading to VMS.”