September 8, 2017
In patients with moderate to severe osteoarthritis knee pain, a single intra-articular injection of 1 mg of CNTX-4975 was well tolerated and significantly improved pain with walking, knee stiffness and physical function, according to findings presented at PAINWeek.
“As our populations are aging, the number of people suffering from moderate to severe knee osteoarthritis is increasing,” Randall M. Stevens, MD, chief medical officer of Centrexion Therapeutics, told Healio Internal Medicine. “Unfortunately, current treatments — like NSAIDs, opioids or hyaluronic acid and corticosteroid injections — are limited in the level of efficacy they provide, and come with significant side effects that can be serious, especially in older individuals. CNTX-4975 for intra-articular injection has shown substantial promise in clinical trials as a long-lasting and efficacious treatment, with a safety profile that looks similar to that of placebo.”