SAN DIEGO — High-dose vitamin D treatment failed to reduce the incidence of postoperative recurrence in patients with Crohn’s disease, according to data presented at Digestive Disease Week.
“Vitamin D deficiency is common in Crohn’s disease and [vitamin D] has potent anti-inflammatory effects,” Marjolijn Duijvestein, PhD, of Amsterdam UMC in the Netherlands, said during her presentation. “When you add vitamin D to T cells, you actually see a decrease of pro-inflammatory cytokines and an increase of anti-inflammatory cytokines.”
Researchers randomly assigned 72 patients with CD to 25,000 IU vitamin D3 and 71 patients to placebo weekly for 6 months after their first or second ileocolonic resection. They found no differences in the incidence or severity of endoscopic recurrence or cumulative clinical recurrence rates at week 26 between the two groups.
High-dose vitamin D treatment failed to reduce the incidence of postoperative recurrence in patients with Crohn’s disease, according to data presented at Digestive Disease Week.
For more Healio coverage of this study, please click here. – by Janel Miller and Alex Young
Reference: Duijvestein M, et al. Abstract 144. Presented at: Digestive Disease Week; May 18-21, 2019; San Diego.
Disclosures: Duijvestein reports financial ties to Echo Pharma, Dr. Falk Pharma, Janssen, Merck, Pfizer, Robarts Clinical Trials, Takeda and Tillots. Please see the meeting disclosure index for all other authors’ relevant financial disclosures.