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Maternal diabetes exposure associated with insulin resistance, decreased insulin sensitivity in offspring

July 25, 2017

Children exposed to maternal diabetes in utero are more likely to experience insulin resistance during childhood and adolescence vs. children not exposed to maternal diabetes, independent of maternal prepregnancy obesity and offspring BMI, according to findings from a longitudinal study.

“The intrauterine environment appears to be particularly important for the development of early-onset type 2 diabetes; however, among people aged at least 20 years, less is known about how intrauterine exposures are related to metabolic abnormalities that are precursors to overt type 2 diabetes, including insulin resistance and altered insulin secretion,” Katherine A. Sauder, PhD, assistant professor of pediatrics at the University of Colorado School of Medicine, and colleagues wrote. “Given that half of women are overweight or obese prior to pregnancy and at least 9% of pregnancies are complicated by maternal diabetes in the USA, a better understanding of how these exposures are associated with offspring diabetes risk is needed to guide early intervention efforts.”

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