Endocrinology

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AMPK activator reduces glucose level in type 2 diabetes in phase 2a trial

November 18, 2017

A novel AMP-activated protein kinase activator showed glucose reduction and decreased cardiovascular risk factors in people with type 2 diabetes in a phase 2a trial, according to a press release from the drug’s developer.

The first-in-class drug (O304, Betagenon/Baltic Bio) activates AMP-activated protein kinase (AMPK), which regulates energy balance. By activating this protein, the researchers aimed to prevent type 2 diabetes and cardiovascular disease.

In the Journals

Nearly 1 in 7 patients with diabetes have poor glycemic control

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About one in seven patients with diabetes had poor glycemic control between 2007 and 2014 despite an increase in the frequency of self-reported testing and patient…
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Patients with Addison's disease show no increase in adipose tissue

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Although patients with Addison’s disease who were treated with glucocorticoids demonstrated increased cortisol exposure, they did not have increased levels of
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Heart failure strongest predictor of poor survival in type 2 diabetes

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Older adults with type 2 diabetes are at increased risk for death from cardiovascular complications, with the strongest associations found between survival and heart…
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Glycemic control, drug regimen interaction influence mortality risk in type 2 diabetes

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The Future of the Lipid Panel: An NLA Expert Discussion

This educational activity is supported by an educational grant from Quest Diagnostics, Inc.

Past-President of the National Lipid Association and Editor-in-Chief of the Journal of Clinical Lipidology, Dr. W…
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Best of Obesity Forum® 2017

This activity is supported by an educational grant from Novo Nordisk, Inc.

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