for Endocrinology BES 2011
Researchers for a new study report that thyroid hormone
levels appear to predict whole body lean mass, fat mass and central adiposity
“This suggests that thyroid hormones play an important role in the
pathogenesis of obesity,” Preethi Rao, MD, of Queen Elizabeth
Hospital, Gateshead, U.K., and colleagues wrote in the study abstract. The data
were presented during the Young Endocrinologists’ Prize Session at the
The researchers conducted a study to assess body composition in
euthyroid women because they said “the relation of body weight
distribution to thyroid function in euthyroid individuals is unclear.”
Their study included more than 1,000 euthyroid women (mean age, 61
years) who were included in the Osteoporosis and Ultrasound Study (OPUS). OPUS
is a population-based cohort study of participants from five European cities.
All of the women had their thyroid function measured in 2001 to 2002, and whole
body adiposity and lean mass were measured using DXA in 2007 to 2008.
According to the researchers’ measurements, the mean
thyroid-stimulating hormone level was 0.86 mIU/L; the mean free thyroxine level
was 12.8 pmol/L; and the mean free triiodothyronine level was 3.7 pmol/L. The
researchers said their study showed a negative correlation between
FT4 levels and whole body and truncal lean mass. Whole body and
truncal fat mass were positively correlated with FT3 levels, but not
with TSH levels. Further, the analysis yielded a positive corelation between
FT3 and TSH levels.
Multiple linear regression analysis revealed that FT3 and TSH
independently predicted whole body and truncal lean mass. In contrast,
FT3 alone predicted whole body and truncal fat mass. The researchers
also found a significant correlation between truncal fat levels and the
FT3 to FT4 ratio.
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Disclosure: The researchers report no relevant financial