The American Thyroid Association Task Force has released 70 new recommendations for standardizing studies regarding thyroid hormone economy and action. The recommendations were compiled based on the lack of standardization that has led to the heterogeneity of results in thyroid research, according to the task force.
“This is an outstanding and comprehensive guide for translational and basic research scientists that has filled an important gap in our thyroid research field,” Bryan R. Haugen, MD, ATA President and professor of medicine and pathology; head of the division of endocrinology, metabolism and diabetes; Mark Kern and Jerome H. Kern Chair in endocrine neoplasm research at the University of Colorado School of Medicine, said in a press release. “Dr. Bianco and the entire taskforce are to be commended for developing this authoritative and extremely useful reference.”
Bryan R. Haugen
Recommendations in this extensive document address:
- Assessment of the thyroid gland;
- Assessment of circulating and tissue thyroid hormone levels;
- Assessment of thyroid hormone transport into cells;
- Assessment of thyroid hormone metabolism;
- Inducement of hypothyroidism and thyroid hormone replacement;
- Increasing thyroid hormone signaling;
- Iodine deficiency and maternal-fetal transfer of thyroid hormone;
- Models of non-thyroidal illness;
- Assessment of thyroid hormone signaling at tissue and cellular levels; and
- Assessment of thyroid hormone signaling by way of systemic biological parameters.
“This is a unique compilation of detailed recommendations for performing experiments focusing on the pathophysiology of the thyroid using cell and animal models. It will guide numerous researchers how to best conduct these experiments and will lead to more standardized approaches in many laboratories worldwide,” Peter A. Kopp, MD, editor-in-chief of Thyroid and associate professor of medicine in the division of endocrinology, metabolism and molecular medicine, and interim director for the Center for Genetic Medicine at Northwestern University Feinberg School of Medicine in Chicago, said in the press release.
For more information:
Bianco AC. Thyroid. 2013;doi:10.1089/thy.2013.0109.
Disclosure: The researchers report no relevant financial disclosures.