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Overall survival low with sorafenib treatment for anaplastic thyroid carcinoma

June 26, 2017

Adults with medullary thyroid carcinoma can be treated safely and effectively with sorafenib, but the agent is less effective for treatment of anaplastic thyroid carcinoma, according to published findings from Japan.

Yasuhiro Ito, MD, PhD, of the Clinical Trial Management Center at Kuma Hospital in Japan, and colleagues evaluated 18 Japanese adults (mean age, 64 years; 11 women) with medullary thyroid carcinoma (n = 8) or anaplastic thyroid carcinoma (n = 10) to determine the safety and efficacy of sorafenib (Nexavar, Bayer; median daily dose, 530 mg; median treatment duration, 15.5 weeks). Treatment with sorafenib was continued in patients until the occurrence of disease progression, unacceptable toxicity or withdrawal of consent.

In the Journals PlusPerspective

Delayed TSH elevation associated with invasive procedures in neonatal ICU newborns

June 22, 2017
Newborns with delayed thyroid-stimulating hormone elevation may experience a greater need for surgery and other invasive procedures compared with newborns without…
In the Journals Plus

Lenvatinib improves OS in older patients with differentiated thyroid cancer

June 22, 2017
Lenvatinib demonstrated higher toxicity in older patients with radioiodine-refractory differentiated thyroid cancer, according to data from a phase 3 trial.

Task force advice against thyroid cancer screening ‘appropriate and timely’

Endocrine Today, June 2017
The U.S. Preventive Services Task Force’s final recommendation against thyroid cancer screening in asymptomatic adults reflects increasing concerns about…
CME

Improving Bone Strength and Reducing Fracture Risk in Osteoporosis

This activity is supported by an educational grant from Merck & Co., Inc.

Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue leading to reduced…
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VIDEO: Ethical issues arise in genetic screening of thyroid cancer

March 7, 2015
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The Endocrine Society Annual Meeting

The Endocrine Society Annual Meeting

CME

Practical Lipidology®: Volume 3, Number 2

This activity is supported by an educational grant from Amgen

The reduction of low-density lipoprotein-cholesterol (LDL-C) is recognized as the primary strategy for decreasing…
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In the Journals Plus

Overall survival low with sorafenib treatment for anaplastic thyroid carcinoma

June 26, 2017
Adults with medullary thyroid carcinoma can be treated safely and effectively with sorafenib, but the agent is less effective for treatment of…

In the Journals PlusPerspective

Delayed TSH elevation associated with invasive procedures in neonatal ICU newborns

June 22, 2017
Newborns with delayed thyroid-stimulating hormone elevation may experience a greater need for surgery and other invasive procedures compared with…

In the Journals Plus

Lenvatinib improves OS in older patients with differentiated thyroid cancer

June 22, 2017
Lenvatinib demonstrated higher toxicity in older patients with radioiodine-refractory differentiated thyroid cancer, according to data from a phase

Task force advice against thyroid cancer screening ‘appropriate and timely’

Endocrine Today, June 2017
The U.S. Preventive Services Task Force’s final recommendation against thyroid cancer screening in asymptomatic adults reflects increasing…

In the Journals Plus

ARIC analysis: Thyroid dysfunction does not increase risk for CVD

June 19, 2017
Middle-aged adults with varying degrees of hypothyroidism and hyperthyroidism have a cardiovascular risk profile that is similar to those without…

In the Journals Plus

Sorafenib alters thyroid hormone levels in patients with hepatocellular carcinoma

June 16, 2017
Sorafenib appeared to alter thyroid function in patients undergoing treatment for hepatocellular carcinoma by inhibiting triiodothyronine

In the Journals Plus

Thyroid dysfunction increases cause-specific mortality risk in women

June 8, 2017
Women with hyperthyroidism have an increased risk for death from breast cancer, and women with hypothyroidism have an increased risk for death from…

In the Journals Plus

Early phthalate exposure diminishes thyroid function in young girls

June 2, 2017
Young girls’ thyroid function may be suppressed after early childhood exposure to specific phthalates, whereas effects of exposure are not as…

In the Journals Plus

Decrease in free T4 increases metabolic syndrome risk

June 2, 2017
The risk for metabolic syndrome may rise with decreasing serum free thyroxine levels, particularly in adults without obesity, according to findings…

In the Journals Plus

Thyroid scintigraphy use decreasing for thyroid carcinoma

June 1, 2017
The use of preoperative thyroid scintigraphy in children, adolescents and young adults with thyroid carcinoma had decreased during a 19-year period…

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