CHICAGO — In this video exclusive, Andrea Dunaif, MD, professor of medicine and system chief for endocrinology, diabetes and bone disease at Mt. Sinai Health System and the Icahn School of Medicine in New York, discusses exciting advances in research into polycystic ovary syndrome, including mechanisms and developmental origins of disease.
Data from mouse models suggest that anti-Müllerian hormone acting centrally on gonadotropin-releasing hormone therapy secretion may be important in the development of PCOS. Other researchers have found rare genetic variants in regulatory portions of several genes that may be involved in the development of PCOS, in particular, DENND1A.
“I think this is absolutely transformative in our concept of what causes PCOS,” Dunaif said.