Children born to mothers who underwent Roux-en-Y gastric bypass are less likely to have birth defects when compared with mothers with obesity who did not undergo weight-loss surgery, according to findings from a research letter published in JAMA.
“In this nationwide matched cohort study we found that bariatric surgery, leading to substantial and sustained weight loss as well as normalization of blood glucose, is associated with a lower risk for birth defects,” Martin Neovius, PhD, a professor with the department of medicine at the Karolinska Institutet in Stockholm, told Endocrine Today. “It is important to know that weight loss surgery has both positive and negative effects, which may influence the risk for birth defects. Nutrient deficiencies caused by the surgery may increase risk, and therefore it is important to take the recommended supplements.”
Neovius and colleagues analyzed data from live-born, singleton infants born between 2007 and 2014, identified via the Swedish Medical Birth Register, born to 2,921 women who underwent Roux-en-Y gastric bypass surgery during the same period (using data from the Scandinavian Obesity Surgery Register) and 30,573 women with obesity but without a history of bariatric surgery (controls). Researchers matched cases with controls by major birth defects in previous pregnancies (identified via National Patient Register), preoperative BMI, diabetes status and delivery year, as well as a propensity score that included maternal age, smoking status, parity and drug use (mean age, 31 years).
Among women who underwent gastric bypass, mean preoperative BMI was 43.5 kg/m², mean weight loss was 40 kg and mean surgery-to-conception interval was 1.6 years. Diabetes drug use fell from 9.7% before surgery to 1.5% during the 6 months before conception.
Children born to mothers who underwent Roux-en-Y gastric bypass are less likely to have birth defects when compared with mothers with obesity who did not undergo weight-loss surgery.
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Researchers observed major birth defects recorded for 98 infants born to mothers with gastric bypass surgery (3.4%) vs. 1,510 infants born to mothers who did not undergo surgery (4.9%), for a risk ratio of 0.67 (95% CI, 0.52-0.87) and a risk difference of 1.6% (95% CI, 2.7 to 0.6).
Major heart defects accounted for 60% (n = 58) of birth defects among infants born to mothers in the surgery group. There were no cases of neural tube defects among the surgery group and 20 cases (0.07%) among controls, with results persisting in sensitivity analyses.
“We can say to mothers that there is no increased risk for birth defects after bariatric surgery, as has been suspected for a long time,” Neovius said. “On the contrary, our study showed a lower risk. However, the results from our study need to be confirmed in other settings, and it is important to stress that women need to take their recommended supplements after surgery, as there is an increased risk for nutritional deficiencies which may have adverse effects on the fetus.”– by Regina Schaffer
Disclosures: Neovius reports he has received advisory boards fees from Itrim and Ethicon Johnson & Johnson. Please see the study for all other authors’ relevant financial disclosures.