Heart Association Scientific Sessions 2010
CHICAGO Low serum vitamin D levels appear to be independently
associated with the development of prehypertension, new data suggest.
Researchers conducted a cross-sectional study of 9,215 participants
included in the National Health and Nutrition Examination Survey (NHANES) III
who were free of hypertension at baseline. Participants were divided into
quartiles based on serum vitamin D levels. The main outcome of interest was
prehypertension (n=3,712), which was defined as systolic blood pressure of 120
mm Hg to 139 mm Hg or diastolic BP of 80 mm Hg to 89 mm Hg.
According to the results, low serum vitamin D levels were associated
with the development of prehypertension, independent of risk factors such as
age, sex, race, smoking, alcohol intake, BMI, physical inactivity, diabetes,
HDL ratio, C-reactive protein and glomerular filtration rate.
When compared with the highest quartile of serum vitamin D (>32.4
ng/mL), the odds of developing prehypertension were increased in the lowest
quartile (≤17.7 ng/mL; OR=1.48; 95% CI, 1.16-1.90). On continuous analysis,
each standard deviation decrease in vitamin D was associated with an odds ratio
of 1.14 (95% CI, 1.05-1.24) of prehypertension.
These findings are largely consistent with previous studies that
examine the association [between low vitamin D levels] and
prehypertension, Charumath Sabanayagam, MD,
PhD, of West Virginia
University, said during his presentation.
The researchers concluded that future randomized trials are needed to
determine if vitamin D supplementation during the prehypertension stage can
prevent the onset of full-blown hypertension. by Eric Raible
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