EXPERT SUMMARIES of the top 30 journals in endocrinology
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Add-on dapagliflozin therapy safe, effective in Asian adults with poorly controlled type 2 diabetes

Yang W, et al. J Diabetes. 2017;doi:10.1111/jdb.12634.
Asian adults with poorly controlled type 2 diabetes experienced a marked improvement in glycemic profile and weight loss when randomly assigned the…
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Skipping breakfast may induce changes in fat metabolism, insulin response

Gonzalez JT, et al. J Physiol. 2017;doi:10.1113/JP275113.
In lean adults, morning fasting directly affects the molecular response of abdominal adipose tissue, increasing the expression of genes involved in…
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Pioglitazone, SGLT2 inhibitors equally effective for reducing HbA1c

Cho YK, et al. J Diabetes Investig. 2017;doi:10.1111/jdi.12787.
Pioglitazone and SGLT2 inhibitors as add-ons to insulin therapy were more effective for lowing HbA1c, fasting plasma glucose and insulin dose…
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Elevated BPA levels found in women with PCOS

Hu Y, et al. Gynecol Endocrinol. 2017;doi:10.1080/09513590.2017.1405931.
Women with polycystic ovary syndrome exhibit higher concentrations of the endocrine-disrupting chemical bisphenol A, or BPA, than those without the…
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Cardiac dysfunction may predict mortality in type 2 diabetes, acute coronary syndrome

Savonitto S, et al. Diab Vasc Dis Res. 2017;doi:10.1177/1479164117735493.
Compared with markers of metabolic dysfunction, markers of cardiac dysfunction may be more effective in predicting the risk for mortality in adults…
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All-cause, CV mortality similar with intensive vs. standard BP lowering in diabetes

Brouwer TF, et al. Diabetes Care. 2017;doi:10.2337/dc17-1722.
Intensive blood-pressure lowering in adults with type 2 diabetes or an increased 10-year cardiovascular risk may not be more effective at reducing CV…
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Metformin exposure in utero may increase infant head size

Hjorth-Hansen A, et al. J Clin Endocrinol Metab. 2017;doi:10.1210/jc.2017-01191.
Among babies born to women with polycystic ovary syndrome, those who were exposed to metformin in utero had larger head circumferences compared with
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Oral therapy as safe, effective as insulin in cystic fibrosis-related diabetes

Ballmann M, et al. Lancet Diabetes Endocrinol. 2017;doi:10.1016/s2213-8587(17)30400-x.
Patients with cystic fibrosis-related diabetes treated with oral repaglinide for 24 months experienced improvements in HbA1c and pulmonary function…
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Night sweats plus hot flashes linked to diabetes risk in postmenopausal women

Gray KE, et al. Menopause. 2017;doi:10.1097/GME.0000000000001033.
The risk for developing diabetes may be increased in postmenopausal women who experience hot flashes accompanied by night sweats, according to…
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Hypoglycemia poses danger for women with gestational diabetes observing Ramadan fast

Afandi BO, et al. BMJ Open Diabetes Res Care. 2017;doi:10.1136/bmjdrc-2017-000470.
Among women with gestational diabetes, those who opted to fast during the Muslim holy month of Ramadan experienced lower mean glucose levels during…
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STAMPEDE: 5 years after bariatric surgery, increased testosterone levels persist

Pham NH, et al. Obes Surg. 2017;doi:10.1007/s11695-017-2881-5.
Men with obesity and poorly controlled type 2 diabetes randomly assigned to bariatric surgery saw a near 50% increase in free testosterone that…
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Long-term weight loss, diabetes remission maintained after RYGB

Courcoulas AP, et al. JAMA Surg, 2017;doi:10.1001/jamasurg.2017.5025.
Higa KD, et al. JAMA Surg. 2017;doi:10.1001/jamasurg.2017.5010.
Adults with obesity who underwent Roux-en-Y gastric bypass were likely to maintain much of their weight loss with variable weight fluctuations long…
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Women with PCOS report ‘sense of inevitability’ regarding weight gain, adverse outcomes

Lin AW, et al. Hum Reprod. 2017;doi:10.1093/humrep/dex351.
Women with polycystic ovary syndrome were more likely to report they had concerns regarding long-term health risks, including cardiovascular disease…
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Type 2 diabetes remission possible with diet, weight loss in primary care

Lean MEJ, et al. Lancet. 2017;doi:10.1016/S0140-6736(17)33102-1.
Uusitupa M. Lancet. 2017;doi:10.1016/S0140-6736(17)33100-8.
An intensive weight management program delivered in the primary care setting was effective for diabetes remission and weight loss in adults with type…
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Probiotic supplementation aids wound healing in diabetic foot ulcer

Mohseni S, et al. Diabetes Metab Res Rev. 2017;doi:10.1002/dmrr.2970.
Patients with a diabetic foot ulcer who received probiotic supplementation for 12 weeks experienced faster wound healing coupled with an improved…
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