EXPERT SUMMARIES of the top 30 journals in endocrinology
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Vitamin D supplementation fails to improve semen quality in men with infertility

Jensen MB, et al. J Clin Endocrinol Metab. 2017;doi:10.1210/jc.2017-01656.
Vitamin D supplementation did not improve the quality of semen in men with infertility and vitamin D deficiency, a randomized clinical trial found
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Use of advanced functions on insulin pumps improves HbA1c in diabetes

Lepore G, et al. Nutr Metab Cardiovasc Dis. 2017;doi:10.1016/j.numecd.2017.12.001.
HbA1c levels were lower in adults and children with diabetes who use advanced pump functions, have a higher rate of sensor use and who have a longer…
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Short-term melatonin supplementation decreases cardiometabolic risk in type 2 diabetes, CHD

Raygan F, et al. Clin Nutr. 2017;doi:10.1016/j.clnu.2017.12.004.
Adults with type 2 diabetes and coronary heart disease who used melatonin supplementation for 12 weeks experienced improvements in biomarkers for…
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Clinical, behavioral diabetes risk factors high in early onset of disease

Bo A, et al. Diabetes Metab Res Rev. 2017;doi:10.1002/dmrr.2968.
Adults with type 2 diabetes who are diagnosed at age 45 years or younger are more likely to have poor glucose control, increased BMI and dyslipidemia…
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NHANES: Nearly 25% of U.S. veterans have diabetes

Liu Y, et al. Prev Chronic Dis. 2017;doi:10.5888/pcd14.170230.
More than 20% of U.S. veterans have diabetes and 3.4% have undiagnosed diabetes, a combined figure that is more than double the diabetes rate in the…
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Incident type 2 diabetes tied to net excess weight in overweight, central obesity

Zameni F, et al. Diabetes Res Clin Pract. 2017;doi:10.1016/j.diabres.2017.12.002.
The risk for incident type 2 diabetes is associated with the degree and duration of excess waist circumference and excess weight, study data show. …
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Advanced glycation end products, oxidation products tied to CVD risk in type 2 diabetes

Koska J, et al. Diabetes Care. 2017;doi:10.2337/dc17-1740.
Adults with type 2 diabetes may be at increased risk for cardiovascular disease with low levels of the oxidation product methionine sulfoxide and…
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Insulin pump therapy improves glucose control, total insulin dose in type 2 diabetes

Chlup R, et al. Diabetes Technol Ther. 2017;doi:10.1089/dia.2017.0283.
Patients with poorly controlled type 2 diabetes and insulin resistance saw an improvement in glycemic profile and a reduction in total daily insulin…
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Depression not linked with glycemic control in adolescents with type 2 diabetes

VanBuren DJ, et al. Diabetes Res Clin Pract. 2017;doi:10.1016/j.diabres.2017.11.008.
Symptoms of depression were not associated with glycemic control in adolescents with type 2 diabetes, although depression was common, according to
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Once-daily glucocorticoid therapy improves immune, metabolic function in adrenal insufficiency

Isidori AM, et al. Lancet Diabetes Endocrinol. 2017;doi:10.1016/s2213-8587(17)30398-4.
Johannsson G. Lancet Diabetes Endocrinol. 2017;doi:10.1016/s2213-8587(17)30431-x.
Patients with primary or secondary adrenal insufficiency assigned to once-daily hydrocortisone therapy for 24 weeks experienced fewer infections and…
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Low vitamin D level may increase risk for heart failure hospitalization

Costanzo S, et al. Nutr Metab Cardiovasc Dis. 2017;doi:10.1016/j.numecd.2017.11.008.
Adults with a low serum 25-hydroxyvitamin D concentration are more likely to be admitted to the hospital with heart failure and spend more days in…
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Meta-analysis: GLP-1 receptor agonists reduce CV risks in type 2 diabetes

Bethel MA, et al. Lancet Diabetes Endocrinol. 2017;doi:10.1016/S2213-8587(17)30412-6.
Taylor SI. Lancet Diabetes Endocrinol. 2017;doi:10.1016/S2213-8587(17)30413-8.
Adults with type 2 diabetes are effectively treated with GLP-1 receptor agonists compared with placebo and experience significant decreases in…
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HbA1c reductions differ with type of second-line drug class

Gottlieb A, et al. BMJ Open Diabetes Res Care. 2017;doi:10.1136/bmjdrc-2017-000435.
HbA1c is significantly reduced in adults with type 2 diabetes when treated with a second-line drug class, but reductions are greater with…
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Levothyroxine treatment does not alter pregnancy outcomes

Wang H, et al. JAMA. 2017;doi:10.1001/jama.2017.18249.
Miscarriage, intrauterine pregnancy and live-birth rates were not affected with levothyroxine treatment in women who were…
In the Journals PlusPerspective

USPSTF recommends against HT for prevention of chronic conditions in postmenopausal women

Gartlehner G, et al. JAMA. 2017;doi:10.1001/jama.2017.16952.
Hormone therapies in menopausal women are associated with some beneficial effects, such as decreased risk for diabetes and fracture, but are also…
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