EXPERT SUMMARIES of the top 30 journals in endocrinology
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In the Journals PlusPerspective

Large weight loss raises fragility fracture risk in type 2 diabetes

Komorita Y, et al. Diabetes Care. 2018;doi:10.2337/dc17-2004.
Adults with type 2 diabetes who lost at least 30% of their maximum body weight had increased risks for fragility fractures and any fracture compared…
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Cinnamon supplement may improve cardiometabolic profile in type 2 diabetes

Zare R, et al. Clin Nutr. 2018;doi:10.1016/j.clnu.2018.03.003.
Patients with type 2 diabetes randomly assigned to twice-daily cinnamon supplementation for 3 months experienced a marked improvement in BMI and…
In the Journals Plus

Levothyroxine adjustment fails to improve quality of life in hypothyroidism

Samuels MH, et al. J Clin Endocrinol Metab. 2018;doi:10.1210/jc.2017-02668.
Quality of life, mood and cognition were unaffected by adjusting levothyroxine dose to achieve thyroid-stimulating hormone levels near the reference…
In the Journals Plus

Antiandrogenic pretreatment decreases gestational diabetes risk in PCOS

Li Y, et al. Fertil Steril. 2018;doi:10.1016/j.fertnstert.2017.12.023.
Pregnant women with polycystic ovary syndrome previously treated with the antiandrogenic therapy ethinylestradiol/cyproterone acetate have a lower…
In the Journals Plus

Bisphosphonate holiday may decrease fracture risk in women

Adams AL, et al. J Bone Miner Res. 2018;doi:10.1002/jbmr.3420.
Women on bisphosphonates for at least 3 years who took a drug holiday for at least 12 months do not appear to have an increased risk for any…
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Prediabetes defined by HbA1c may lead to worse prognosis

Vistisen D, et al. Diabetes Care. 2018;doi:10.2337/dc17-2530.
Adults with prediabetes defined by HbA1c levels were more likely to have an increased risk for cardiovascular disease or all-cause mortality compared…
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Diabetes self-management behaviors, goals differ by ethnicity

Peyrot M, et al. J Diabetes Complications. 2018;doi:10.1016/j.jdiacomp.2018.03.002.
White, African-American, Hispanic-American and Chinese-American adults with diabetes self-reported common goals for improving healthy eating and…
In the Journals Plus

Obesity drives risk for influenza-related hospitalization

Karki S, et al. Int J Obes. 2018;doi:10.1038/s41366-018-0029-x.
Among adults with overweight or obesity, each-5 kg/m² increase in BMI is associated with a 40% increase in the risk for influenza-related…
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Soy formula associated with estrogenic response in infant girls

Adgent MA, et al. J Clin Endocrinol Metab. 2018;doi:10.1210/jc.2017-02249.
Infant girls fed soy formula from birth had a higher vaginal cell maturation index and lower uterine volume involution over the first 9 months of…
In the Journals Plus

Antihistamine use may be linked with impaired fertility in men

Mondillo C, et al. Reproduction. 2018;doi:10.1530/REP-17-0685.
The overuse of over-the-counter antihistamine medications may be associated with impaired fertility in men, according to a review of animal and human…
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Thyroid autoantibodies in pregnancy linked to risk for hypertensive disorders of pregnancy

Han Y, et al. Clin Endocrinol. 2018;doi:10.1111/cen.13590.
Pregnant women positive for anti-thyroperoxidase autoantibody and anti-thyroglobulin autoantibody during their first trimester are at increased risks…
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No increased fracture risk identified with sarcopenia

Trajanoska K, et al. J Bone Miner Res. 2018;doi:10.1002/jbmr.3416.
Adults with pre-sarcopenia or sarcopenia are no more likely to sustain a fracture than adults with osteoporosis without sarcopenia, according to…
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Maternal congenital hypothyroidism associated with developmental delays in offspring

Leger J, et al. Eur J Endocrinol. 2018;doi:10.1530/EJE-17-0855.
Children born to mothers with congenital hypothyroidism were four times more likely to have low motor coordination at age 1 year vs. children of the…
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HIV linked to higher risks for obesity, cardiovascular disease

Gelpi M, et al. Clin Infect Dis. 2018;doi:10.1093/cid/ciy146.
HIV infection is associated with a greater risk for abdominal obesity and, perhaps indirectly, a greater risk for elevated LDL cholesterol and…
In the Journals PlusPerspective

Menopausal HT not linked to adverse changes in cardiac structure

Sanghvi MM, et al. PLoS One. 2018;doi:10.137/journal.pone.0194015.
Postmenopausal women using menopausal hormone therapy for at least 3 years were not at increased risk for adverse, subclinical changes in cardiac…
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