EXPERT SUMMARIES of the top 30 journals in endocrinology
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Oral macimorelin safe diagnostic test for adult GH deficiency

Garcia JM, et al. J Clin Endocrinol Metab. 2018;doi:10.1210/jc.2018-00665.
Among adults with suspected growth hormone deficiency, the oral ghrelin agonist macimorelin is a safe and effective alternative GH stimulation agent…
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HT may help slow cognitive decline in postmenopausal women with mild cognitive impairment

Yoon BK, et al. Menopause. 2018;doi:10.1097/GME.0000000000001140.
The use of percutaneous estradiol gel and oral micronized progesterone during long-term hormone therapy may reduce cognitive decline in…
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Thyroid function in early pregnancy may predict gestational diabetes risk

Rawal S, et al. J Clin Endocrinol Metab. 2018;doi:10.1210/jc.2017-02442.
Among pregnant women, a thyroid hormone marker indicating the conversion rate from thyroxine to triiodothyronine measured during the first and second…
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Cancer increases risk for subsequent diabetes

Hwangbo Y, et al. JAMA Oncol. 2018;doi:10.1001/jamaoncol.2018.1684.
Cancer increased patients’ risk for subsequently developing diabetes, according to results of a cohort study conducted in South Korea…
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Work stress increases mortality risk in men with cardiometabolic disease

Kivimäki M, et al. Lancet Diabetes Endocrinol. 2018;doi:10.1016/s2213-8587(18)30140-2.
Among men with diabetes, history of stroke or coronary heart disease, job strain increases the risk for death independent of socioeconomic status and…
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Increased weight associated with height loss in postmenopausal women

Mai X, et al. Menopause. 2018;doi:10.1097/GME.0000000000001108.
Height loss in postmenopausal women can be predicted by several factors, including older age, use of oral corticosteroids, strenuous exercise in…
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In women, diabetes triples risk for CVD death

Prospective Studies Collaboration. Lancet Diabetes Endocrinol. 2018;doi:10.1016/s2213-8587(18)30079-2.
In a large, international cohort of adults with no previous vascular disease, diabetes tripled the risk for death from ischemic heart disease or…
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Lifestyle intervention promotes weight loss after gestational diabetes

June 5, 2018
Women with a history of gestational diabetes who participated in a postnatal lifestyle intervention program experienced greater weight loss at 6…
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Alternatives to waist circumference, BMI ‘weak’ predictors of cardiometabolic risk

Barazzoni R, et al. Clin Nutr. 2018;doi:10.1016/j.clnu.2018.04.014.
Alternative surrogate measurements of central body shape and fat accumulation are not superior indicators of cardiometabolic risk when compared…
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Medical therapy ‘reasonable option’ vs. surgery in Cushing’s disease

Broersen LHA, et al. Pituitary. 2018;doi:10.1007/s11102-018-0897-z.
In a large percentage of patients with Cushing’s disease, medical therapy effectively induces cortisol normalization, suggesting the choice may…
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Childhood hyperthyroidism may be on the rise

Simon M, et al. J Clin Endocrinol Metab. 2018;doi:10.1210/jc.2018-00273.
Incidence of childhood hyperthyroidism in France, although rare, may be on the rise, peaking during adolescence and affecting girls more than boys…
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Osteoporosis associated with risk for sudden hearing loss

Kim SY, et al. J Clin Endocrinol Metab. 2018;doi:10.1210/jc.2018-00717.
Among adults aged at least 50 years, osteoporosis may be an independent risk factor for sudden sensory neural hearing loss, according to an analysis…
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Thyroid cancer doubles risk for heart disease in men vs. women

Park J, et al. J Clin Endocrinol Metab. 2018;doi:10.1210/jc.2017-02629.
Male thyroid cancer survivors are twice as likely to develop cardiovascular disease in the 5 years after diagnosis vs. women, according to findings…
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Lifestyle advice alone fails to reduce type 2 diabetes risk

Jølle A, et al. Open Diab Res Care.2018;doi:10.1136/bmjdrc-2018-000509.
Among Norwegian adults at high risk for developing type 2 diabetes, twice-yearly group sessions designed to teach lifestyle modifications did not…
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In metabolically healthy obesity, risk remains for CVD in women

Eckel N, et al. Lancet Diabetes Endocrinol. 2018;doi:10.1016/s2213-8587(18)30137-2.
Women with metabolically healthy obesity are at increased long-term risk for cardiovascular disease vs. metabolically healthy normal-weight women…
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