EXPERT SUMMARIES of the top 30 journals in endocrinology
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Fenofibrate reduces gout incidence in type 2 diabetes

Waldman B, et al. Lancet Diabetes Endocrinol. 2018;doi:10.1016/s2213-8587(18)30029-9.
Adults with type 2 diabetes and high levels of uric acid assigned the dyslipidemia medication fenofibrate experienced a 20% reduction in uric acid…
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Decreasing BMI from young adulthood to midlife reduces incident diabetes risk

Stokes A, et al. Diabetes Care. 2018;doi:10.2337/dc17-2336.
Adults with obesity in young adulthood who dropped to a nonobese BMI category during midlife had reduced risk for developing diabetes compared with…
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Extra-thyroid extension increases recurrence rates in differentiated thyroid cancer

Diker-Cohen T, et al. J Clin Endocrinol Metab. 2018;doi:10.1210/jc.2018-00081.
Extra-thyroid extension increases the risk for disease recurrence in adults with differentiated thyroid cancer compared with those without extension…
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Excess mortality falling, pituitary surgery increasing for acromegaly

Esposito D, et al. Eur J Endocrinol. 2018;doi:10.1530/EJE-18-0015.
Excess mortality for adults diagnosed with acromegaly has markedly declined in past 3 decades, with researchers also observing an increase in the use…
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Gut hormones appear to mediate impaired bone turnover markers in NAFLD with type 2 diabetes

Maagensen H, et al. J Clin Endocrinol Metab. 2018;doi:10.1210/jc.2018-00176.
Adults with nonalcoholic fatty liver disease and type 2 diabetes had impaired collagen type 1 C-telopeptide suppression in response to an oral…
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Rheumatoid arthritis drug may lower blood glucose levels in type 2 diabetes

Chen J, et al. J Endocrinol. 2018;doi:10.1530/JOE-17-0536.
An active metabolite in the rheumatoid arthritis treatment leflunomide may inhibit a protein that affects insulin-receptor signaling in mice, making…
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Serum creatinine level associated with type 2 diabetes risk in men

Takeuchi M, et al. BMJ Open Diabetes Res Care. 2018;doi:10.1136/bmjdrc-2017-000492.
Healthy men with a low level of serum creatinine are nearly twice as likely to develop type 2 diabetes over 6 years vs. men with a high baseline…
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Fat mass increased in adolescents assigned probiotic supplement

Hispanic adolescents assigned to 16 weeks of supplementation with a commercial probiotic formulation experienced an increase in total adiposity…
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Vitamin D supplementation fails to lower HbA1c in type 2 diabetes

Angellotti E, et al. J Endocr Soc. 2018;doi:10.1210/js.2018-00015.
Older adults with well-controlled type 2 diabetes assigned 4,000 IU daily vitamin D for 48 weeks saw no changes in insulin secretion rate or HbA1c…
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Radioactive iodine treatment for thyroid cancer may adversely affect ovarian reserve

Yaish I, et al. Thyroid. 2018;doi:10.1089/thy.2017.0442.
Women with differentiated thyroid cancer treated with radioactive iodine ablation experienced decreased anti-Müllerian hormone levels 3 months…
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Researchers propose 5 distinct types of adult-onset diabetes

Ahlqvist E, et al. Lancet Diabetes Endocrinol. 2018;doi:10.1016/S2213-8587(18)30051-2.
Researchers have developed a novel diabetes classification system that calls for five distinct disease etiologies to better target early treatment to…
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Declines in anti-Müllerian hormone faster, ovarian volume slower in PCOS

Ahmad AK, et al. Fertil Steril. 2018;doi:10.1016/j.fertnstert.2017.11.012.
Compared with healthy controls, women with polycystic ovary syndrome demonstrated a slower decline in ovarian volume with aging and a faster decline…
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Endoscopically implanted device safe, effective in obesity, type 2 diabetes

Patel N, et al. Obes Surg. 2018;doi:10.1007/s11695-018-3123-1.
A duodenal-jejunal bypass liner was safe and effective in treating adults with obesity and type 2 diabetes and may serve as an alternative to…
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Low testosterone increases mortality risk in metabolic syndrome

Laouali N, et al. J Endocr Soc. 2018;doi:10.1210/js.2018-00005.
Older men with metabolic syndrome and low levels of total and bioavailable testosterone are more likely to die of any cause over 12 years vs. men…
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IDegLira reduces hypoglycemia rates in uncontrolled type 2 diabetes

Billings LK, et al. Diabetes Care. 2018;doi:10.2337/dc17-1114.
Adults with uncontrolled type 2 diabetes treated with a fixed-ratio combination of insulin degludec and liraglutide, or IDegLira, experienced lower…
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