EXPERT SUMMARIES of the top 30 journals in endocrinology
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Analysis: Marked, bimodal distribution of testosterone between genetic males, females

Clark RV, et al. Clin Endocrinol. 2018;doi:10.1111/cen.13840.
Normal testosterone ranges for adult women and men differ markedly with a bimodal distribution, with the lower limit of the male range approximately…
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No increased CVD risk observed in PCOS

Jacewicz-Swiecka M, et al. Diabetes Metab Res Rev. 2018;doi:10.1002/dmrr.3054.
Women with polycystic ovary syndrome are at higher
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New edition of thyroid cancer staging system shows better prediction of survival

van Velsen EFS, et al. Thyroid. 2018;doi:10.1089/thy.2018.0066.
The eighth edition of the American Joint Committee on Cancer/tumor node metastasis staging system for differentiated thyroid cancer was a better…
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High aldosterone level may raise type 2 diabetes risk

Joseph JJ, et al. J Am Heart Assoc. 2018;doi:10.1161/JAHA.118.009890.
Adults with higher aldosterone levels are more likely to develop type 2 diabetes over 10 years vs. those with lower levels, with the risk further…
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Weight Watchers provides cost-effective obesity prevention vs. standard care

Lymer S, et al. Obesity. 2018;doi:10.1002/oby.22216.
Commercial weight-management programs, such as the Weight Watchers intervention, may be cost-effective alternatives to standard care for Australian…
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Age, tumor size may predict papillary thyroid carcinoma recurrence

Tran B, et al. Thyroid. 2018;doi:10.1089/thy.2017.0607[JR1]
For adults aged 55 years and older, tumor size can be an accurate means to predict recurrence of papillary thyroid carcinoma, with every 1-cm…
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Calcium supplement formulations similarly ineffective for normalizing parathyroid hormone following bariatric surgery

Madsen LR. Clin Endocrinol. doi: 10.1111/cen.13836
In adults with slightly elevated parathyroid hormone following Roux-en-Y gastric bypass surgery, supplementation with either calcium carbonate or…
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SGLT2 inhibitor well tolerated in East Asian adults with type 2 diabetes

Yabe D, et al. J Diabetes Investig. 2018;doi:10.1111/jdi.12910.
The SGLT2 inhibitor empagliflozin, used to manage type 2 diabetes, was well tolerated by adults in East Asia with more than 2,100 patient-years of…
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Chemotherapy increases early menopause risk for women with lung cancer

Cathcart-Rake, E, et al. Menopause. 2018;doi:10.1097/GME.0000000000001199
Among women with lung cancer, chemotherapy may elevate the likelihood of amenorrhea and early menopause, according to research published in…
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No cognitive defects observed in small-for-gestational age children receiving long-term hormone therapy

Goedegebuure WJ, et al. J Clin Endocrinol Metab. 2018;doi:10.1210/jc.2018-01463.
In children born small for gestational age, treatment with combined growth hormone/gonadotropin-releasing hormone analogue does not appear to have…
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Earlier treatment intensification yields shorter time to glycemic control in type 2 diabetes

Desai U. Diabetes Care. 2018;doi:10.2337/dc17-0662.
In adults with uncontrolled type 2 diabetes prescribed metformin or sulfonylurea monotherapy, earlier addition of a second noninsulin drug is
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Childhood obesity leads to comorbidities in adults with severe obesity

Borgeraas H, et al. Obes Sci Pract. 2018;doi:10.1002/osp4.298.
The onset of obesity in childhood puts men with severe obesity at greater risk for developing coronary heart disease and women with severe obesity at…
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Men with BRAF-mutated papillary thyroid cancer may have worse survival outcomes

Wang F, et al. J Clin Oncol. 2018;doi:10.1200/JCO.2018.78.5097.
Male sex appeared to be an independent risk factor for poor clinical outcomes among patients with BRAF V600E-mutated papillary thyroid cancer…
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3 second-line type 2 diabetes therapies similarly lower HbA1c

Vashisht R, et al. JAMA Netw Open. 2018;doi:10.1001/jamanetworkopen.2018.1755.
An international, collaborative analysis of data from more than 246 million patients with type 2 diabetes suggests that three second-line…
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Probiotic supplementation may confer cardiometabolic benefits in type 2 diabetes

Sabico S, et al. Clin Nutr. 2018;doi:10.1016/j.clnu.2018.08.009.
Adults with newly diagnosed type 2 diabetes randomly assigned to twice-daily, multi-strain probiotic therapy for 6 months experienced improvements in…
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