EXPERT SUMMARIES of the top 30 journals in endocrinology
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Early pregnancy iron deficiency may predict hypothyroxinemia in second, third trimester

Teng X, et al. Thyroid. 2018;doi:10.1089/thy.2017.0491.
Pregnant women with iron deficiency in the first trimester are more likely to have lower levels of free thyroxine and an increased risk for…
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‘Normal-weight obesity’ linked to cardiometabolic risk in Chinese adults

Jia A, et al. Nutr Metab Cardiovasc Dis. 2018;doi:10.1016/j.numecd.2018.06.015.
Normal-weight obesity — defined as a high body fat percentage in the setting of normal BMI — is relatively common in China, and the…
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Levothyroxine dose in infancy may predict transient congenital hypothyroidism in children

Saba C, et al. Thyroid. 2018;doi:10.1089/thy.2018.0154.
Infants prescribed a lower dose of levothyroxine therapy for congenital hypothyroidism with a eutopic thyroid gland are more likely to have a…
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Parkinson's disease risk nearly doubles for those with diabetic retinopathy

Eun Lee S, et al. J Clin Endocrinol Metab. 2018;doi:10.1210/jc.2017-02774.
Adults with diabetic retinopathy are nearly twice as likely to develop Parkinson’s disease as those without the condition, according to a study…
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In childhood cancer survivors, GH therapy improves height without secondary tumor risk

Tamhane S, et al. J Clin Endocrinol Metab. 2018;doi:10.1210/jc.2018-01205.
In childhood cancer survivors, treatment with growth hormone was associated with gains in height vs. untreated control patients without increased…
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Renal calcifications associated with disease severity in primary hyperparathyroidism

Ejlsmark-Svensson H, et al. J Clin Endocrinol Metab. 2018;doi:10.1210/jc.2018-00923.
Patients with primary hyperparathyroidism have a high prevalence of renal calcifications that are typically linked to the severity of the disease
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Maternal healthy lifestyle may lower obesity risk in offspring

Dhana K, et al. BMJ. 2018;doi:10.1136/bmj.k.2486.
Women who maintain an overall healthy lifestyle, characterized by a healthy BMI, regular exercise, not smoking and moderate consumption of alcohol…
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Thyroid function, antibody positivity associated with ovarian reserve in infertility

Korevaar T, et al. Thyroid. 2018;doi:10.1089/thy.2017.0582.
Among women with diminished ovarian reserve or unexplained infertility, low serum free triiodothyronine and thyroid peroxidase antibody positivity…
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Low-dose glucocorticoid exposure increases osteoporotic fracture risk

Balasubramanian A, et al. J Bone Miner Res. 2018;doi:10.1002/jbmr.3523.
Among patients with various inflammatory conditions, exposure to glucocorticoids at doses as low as 5 mg per day may be associated with increased
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New Endocrine Society guideline stresses regular screenings for childhood cancer survivors

Sklar CH, et al. J Clin Endocrinol Metab. 2018;doi:10.1210/jc.2018-01175/5046572.
Childhood cancer survivors who underwent radiation therapy should be screened regularly for growth disorders, pituitary hormone deficiencies and…
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Even low levels of air pollution increase risk for diabetes

Bowe B, et al. Lancet Planet Health. 2018;doi:10.1016/S2542-5196(18)30140-2.
Exposure to air pollution may contribute to millions of new diabetes cases globally each year, according to a study published in The Lancet
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Higher-dose hydrocortisone may reduce symptoms in secondary adrenal insufficiency

Sorgdrager FJH, et al. J Clin Endocrinol Metab. 2018;doi:10.1210/jc.2018-00582.
Among patients with secondary adrenal insufficiency, a 10-week treatment with a higher dose of hydrocortisone lowered the metabolism of tryptophan…
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Hormone therapy increases diabetes risk among breast cancer survivors

Hamood H, et al. J Clin Oncol. 2018;doi:10.1200/JCO.2017.76.3524.
Hormone therapy appeared associated with an increased risk for diabetes among women who survived breast cancer, according to researchers in Israel…
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Statin use may lower fracture risk after stroke

Lin SM, et al. J Clin Endocrinol Metab. 2018;doi:10.1210/jc.2018-00652.
Adults prescribed statin therapy after a stroke were less likely to sustain a fracture vs. similar patients not prescribed statin therapy, according…
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In secondary hypogonadism, free testosterone levels may predict sexual function in men

Rastrelli G, et al. Clin Endocrinol. 2018;doi:10.1111/cen.13756.
The onset of secondary hypogonadism is associated with the development or worsening of androgen deficiency symptoms only when total testosterone and…
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