EXPERT SUMMARIES of the top 30 journals in endocrinology
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Combined treatment with mycophenolate improves response in Graves' orbitopathy

Kahaly GJ, et al. Lancet Diabetes Endocrinol. 2018;doi:10.1016/S2213-8587(18)30020-2.
In patients with Graves’ orbitopathy, adding the immunosuppressant drug mycophenolate to glucocorticoid therapy appeared to improve treatment…
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Bariatric surgery outperforms abdominoplasty for glycemic control in type 2 diabetes

Abdelhafez AH, et al. Bariatr Surg Pract Patient Care. 2017;doi:10.1089/bari.2017.0042.
Adults with type 2 diabetes who underwent abdominoplasty to reduce subcutaneous adipose tissue experienced small improvements in glycemic control…
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Implantable glucose sensor safe, accurate in type 1, type 2 diabetes

Christiansen MP, et al. Diabetes Technol Ther. 2018;doi:10.1089/dia.2017.0142.
An implantable, subcutaneous continuous glucose sensor for patients with type 1 and type 2 diabetes was shown to be safe and accurate over 90 days…
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Central obesity raises fall risk in older adults with normal weight

Cho BY, et al. Am J Prev Med. 2018;doi:10.1016/j.amepre.2017.12.020.
Older adults of normal weight but with central obesity are nearly twice as likely to experience a fall during a 2-year period than adults with…
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Bariatric surgery reduces need for diabetes drugs

Thereaux J, et al. JAMA Surg. 2018;doi:10.1001/jamasurg.2017.6163.
Adults with obesity who underwent bariatric surgery were more likely to discontinue and less likely to initiate treatment with antidiabetes…
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Eating slowly may encourage weight loss in type 2 diabetes with obesity

Hurst Y, et al. BMJ Open. 2018;doi:10.1136/bmjopen-2017-019589.
Adults with type 2 diabetes who reported “fast” eating speeds had a higher risk for obesity than those who reported eating at…
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Sleeve gastrectomy reduces structural markers of atherosclerosis

Altin C, et al. Nutr Metab Cardiovasc Dis. 2018;doi:10.1016/j.numecd.2018.02.001.
Patients with obesity who underwent laparoscopic sleeve gastrectomy experienced a marked reduction in the 6 months after the procedure in carotid…
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Newly identified adipokine associated with bone density in type 2 diabetes

Zhou J, et al. Clin Endocrinol. 2018;doi:10.1111/cen.13560.
Patients with type 2 diabetes and osteopenia or osteoporosis have lower levels of serum retinol-binding protein 4, suggesting the adipokine may play…
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Food insecurity tied to high HbA1c in adolescents with type 1 diabetes

Mendoza JA, et al. Diabetes Res Clin Pract. 2018;doi:10.1016/j.diabres.2018.01.035.
Adolescents with type 1 diabetes livings in households with low and very low food security have higher HbA1c and higher prevalence of…
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Insulin resistance markers associated with DPP-IV inhibitor response in type 2 diabetes

Dennis JM, et al. Diabetes Care. 2018;doi:10.2337/dc17-1827.
Among a cohort of patients with type 2 diabetes, those with markers for higher insulin resistance responded poorly to DPP-4 inhibitor therapy…
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GH does not benefit BMD in Prader-Willi syndrome after adult height attainment

Donze SH, et al. Clin Endocrinol. 2018;doi:10.1111/cen.13567.
Adolescents with Prader-Willi syndrome who continued growth hormone therapy after they reached adult height did not maintain bone density, according…
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Bariatric surgery yields greater metabolic benefits than intensive medical therapy

Simonson DC, et al. Diabetes Care. 2018;doi:10.2337/dc17-0487.
Adults with type 2 diabetes and obesity assigned to Roux-en-Y gastric bypass were more likely to experience improvements in HbA1c and fasting plasma…
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Sarcopenic obesity common in acute lymphoblastic leukemia survivors

Marriott CJC, et al. Cancer. 2017;doi:10.1002/cncr.31191.
Long-term survivors of acute lymphoblastic leukemia frequently experience sarcopenic obesity, which affects their overall health-related quality of…
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Insulin resistance, metabolic dysfunction common in Bardet-Biedl syndrome

Mujahid S, et al. J Clin Endocrinol Metab. 2018;doi:10.1210/jc.2017-01459.
Adults with Bardet-Biedl syndrome are more than twice as likely to have insulin resistance and metabolic syndrome vs. healthy adults; however, most…
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Free androgen index ‘misleading’ indicator of hyperandrogenism in women with low SHBG

Keevil BG, et al. Clin Endocrinol. 2018;doi:10.1111/cen.13561.
Among women with a low concentration of sex hormone-binding globulin, the free androgen index, or FAI, used to assess hyperandrogenism may provide a…
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