EXPERT SUMMARIES of the top 30 journals in endocrinology
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GLP-1 agonists reduce risks for CV, all-cause mortality in type 2 diabetes

Perrone-Filardi P, et al. Nutr Metab Cardiovasc Dis. 2017;doi:10.1016/j.numecd.2017.09.006.
A recently published meta-analysis found that GLP-1 agonists substantially reduced both cardiovascular and all-cause mortality in patients with type
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Short-term probiotic supplementation may aid weight loss

Borgeraas H, et al. Obes Rev. 2017;doi:10.1111/obr.12626.
Adults with overweight or obesity who used a probiotic supplement experienced greater reductions in weight, BMI, fat mass and fat percentage compared…
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Lenvatinib effective for differentiated thyroid cancer despite adverse effects

Amandine B, et al. Thyroid. 2017;doi:10.1089/thy.2017.0205.
The use of lenvatinib for the treatment of radioiodine-refractory differentiated thyroid cancer in adults was relatively effective, but adverse…
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SCALE: Liraglutide increases health-related quality of life in obesity, prediabetes

Kolotkin RL, et al. Clin Obes. 2017;doi:10.1111/cob.12226.
Adults with obesity and prediabetes showed 3-year improvements in health-related quality of life and weight loss with once-daily subcutaneous…
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Long-acting pasireotide safe, effective for recurrent Cushing’s disease

Lacroix A, et al. Lancet Diabetes Endocrinol. 2017;doi:10.1016/s2213-8587(17)30326-1.
In patients with persistent or recurring Cushing’s disease after surgery, monthly pasireotide was safe and effective, leading to normal urinary…
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Brain glucose levels diminished in obesity, type 2 diabetes during hyperglycemia

Hwang JJ, et al. JCI Insight. 2017;doi:10.1172/jci.insight.95913.
Adults with obesity or poorly controlled type 2 diabetes have decreased intracerebral glucose levels that can lead to adverse neurocognitive…
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Commercial weight-management program effective for diabetes prevention

Piper C, et al. BMJ Open Diabetes Res Care. 2017;doi:10.1136/bmjdrc-2017-000418.
Adults at high risk for type 2 diabetes may successfully reduce that risk — and their body weight — when participating in a diabetes…
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Prolactinoma increases CVD risk in men

Toulis KA, et al. Clin Endocrinol. 2017;doi:10.1111/cen.13498.
Men with prolactinoma are at higher risk for incident cardiovascular disease compared with women with prolactinoma and healthy men and women…
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Consensus statement: Diabetes language matters

Dickinson JK, et al. Diabetes Care. 2017;doi:10.2337/dci17-0041.
Health care providers should employ neutral, nonjudgmental language that puts a patient with diabetes before the disease to remove pervasive…
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Adverse event reports of acute renal failure more numerous with SGLT2 inhibitors vs other agents

Perlman A, et al. Nutr Metab Cardiovasc Dis. 2017;doi:10.1016/j.numecd.2017.10.011.
Compared with other diabetes medications, SGLT2 inhibitors were associated with more reports of acute renal failure in the FDA adverse event report…
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Favorable outcomes seen for lung-only metastatic thyroid cancer

Sohn SY, et al. Clin Endocrinol. 2017;doi:10.1111/cen.13489.
Results of a retrospective study conducted in South Korea demonstrated that most patients with metastatic differentiated thyroid cancer confined to
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Gestational diabetes often leads to poor metabolic health in offspring

Grunnet LG, et al. Diabetes Care. 2017;doi:10.2337/dc17-0514.
Children of mothers who had gestational diabetes are more likely to have increased adiposity, an adverse cardiometabolic profile and early onset of…
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Statin therapy increases risk for incident diabetes in high-risk adults

Crandall JP, et al. BMJ Open Diabetes Res Care. 2017;doi:10.1136/bmjdrc-2017-000438.
Adults with prediabetes who participated in the Diabetes Prevention Program Outcomes Study were more likely to develop incident type 2 diabetes if…
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Neurodevelopment unaffected by maternal iodine supplementation

Bath SC. Lancet Diabetes Endocrinol. 2017;doi:10.1016/s2213-8587(17)30331-5.
Gowachirapant S, et al. Lancet Diabetes Endocrinol. 2017;doi:10.1016/s2213-8587(17)30332-7.
In iodine-deficient pregnant women, supplementation with daily oral iodine did not affect the neurodevelopment of offspring at age 5 to 6 years…
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Malignant thyroid nodules grow faster than benign nodules

Angell TE, et al. J Clin Endocrinol Metab. 2017;doi:10.1210/jc.2017-01832.
Malignant thyroid nodules are more likely to grow at least 2 mm per year and increase in volume compared with benign thyroid nodules, according to…
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