EXPERT SUMMARIES of the top 30 journals in endocrinology
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Hyperandrogenism may alter gut microbiome in PCOS

Torres PT, et al. J Clin Endocrinol Metab. 2018;doi:10.1210/jc.2017-02153.
White women diagnosed with polycystic ovary syndrome have a reduction in overall species richness in the gut microbiome and changes in microbial…
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Meta-analysis: SGLT2 inhibitors safe, effective in treating type 1 diabetes

El Masri D, et al. Diabetes Res Clin Pract. 2018;doi:10.1016/j.diabres.2018.01.004.
Combined treatment with SGLT2 inhibitors and insulin is a viable option for treating patients with type 1 diabetes, according to results from a…
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Prevalence of obesity, hypertension, diabetes rising in sub-Saharan Africa

Price AJ, et al. Lancet Diabetes Endocrinol. 2018;doi:10.1016/s2213-8587(17)30432-1.
Rates of overweight, obesity, hypertension and type 2 diabetes are rising across both urban and rural areas of Malawi, with highest disease burden of…
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Increasing BMI raises risk for major renal events in type 2 diabetes

Mohammedi K, et al. Nutr Diabetes. 2018;doi:10.1038/s41387-017-0012-y.
Adults with type 2 diabetes and overweight or obesity are more likely to experience a major renal event over 5 years, including new microalbuminuria…
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Seasonal variation associated with gestational diabetes risk

Vasileiou V, et al. Eur J Endocrinol. 2018;doi:10.1530/EJE-17-0730.
Women who are pregnant appear to be at increased risk for gestational diabetes during the summer months compared with winter months, but they may…
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Dual therapy ertugliflozin, sitagliptin improves glycemic control in type 2 diabetes

Miller S, et al. Diabetes Ther. 2018;doi:10.1007/s13300-017-0358-0.
Patients with poorly controlled type 2 diabetes assigned to combination SGLT2 inhibitor and DPP-IV inhibitor therapy for 6 months saw a marked…
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Infection risks may increase with type 1 diabetes

Carey IM, et al. Diabetes Care. 2018;doi:10.2337/dc17-2131.
Compared with the general public, people with diabetes — and type 1 diabetes, in particular — have increased risks for serious…
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Diabetes increases breast cancer mortality risk

Lega IC, et al. Diabetes Care. 2018;doi:10.2337/dc17-2012.
Women with breast cancer and diabetes have a greater risk for all-cause and cancer-specific mortality and are less likely to receive chemotherapy and…
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Maternal hypothyroidism may influence risk for neurodevelopmental disorders in offspring

Thompson W, et al. Clin Endocrinol. 2018;doi:10.1111/cen.13550.
Children born to women with subclinical hypothyroidism and hypothyroxinemia during pregnancy are more likely to have an intellectual disability than…
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Teriparatide reduces fracture risk in women with severe osteoporosis

Geusens P, et al. J Bone Miner Res. 2018;doi:10.1002/jbmr.3384.
Postmenopausal women with severe osteoporosis may have a lower risk for new vertebral fractures when treated with the anabolic agent teriparatide…
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Graves’ orbitopathy risk linked to cholesterol levels

Sabini E, et al. Thyroid. 2018;doi:10.1089/thy.2017.0430.
In adults with Graves’ disease, the risk for Graves’ orbitopathy may be associated with increased levels of total and LDL cholesterol…
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PCOS-like characteristics do not raise diabetes risk in women with overweight

Kim C, et al. J Clin Endocrinol Metab. 2017;doi:10.1210/jc.2017-01829.
Irregular menses and elevated androgen concentrations did not increase risk for coronary artery calcification or diabetes among women with glucose…
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All-cause, CVD mortality tied to 25-(OH)D concentrations

Degerud E, et al. J Clin Endocrinol Metab. 2018;doi:10.1210/jc.2017-02328.
Adults with suspected stable angina pectoris who have serum 25-hydroxyvitamin D levels less than 42.5 nmol/L or more than 100 nmol/L have an…
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US diabetes detection rates remain low for some populations

Geiss LS, et al. BMJ Open Diabetes Res Care. 2018;doi:10.1136/bmjdrc-2017-000487.
The overall detection rate of undiagnosed type 2 diabetes in the United States did not increase between 1999 and 2014, despite small improvements…
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Early radioactive iodine initiation may improve treatment response after thyroidectomy

Li H, et al. Clin Endocrinol. 2018;doi:10.1111/cen.13551.
Adults with differentiated thyroid cancer who underwent thyroidectomy and started radioiodine therapy 3 or more months after surgery may have an…

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