EXPERT SUMMARIES of the top 30 journals in endocrinology
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Case management increases bisphosphonate treatment uptake after fragility fracture

Majumdar SR, et al. J Bone Miner Res. 2018;doi:10.1002/jbmr.3557.
Adults who sustained an upper-extremity fragility fracture were more likely to initiate bisphosphonate treatment if participating in a fracture…
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Early signs of fatty liver, subclinical heart disease found in children with metabolically healthy obesity

Di Bonito P, et al. Nutr Metab Cardiovasc Dis. 2018;doi:10.1016/j.numecd.2018.08.007.
Despite a lack of conventional cardiometabolic risk factors, children with so-called metabolically healthy obesity have a higher prevalence of…
In the Journals Plus

Melatonin may play role in diabetes risk in men

Obayashi K, et al. Clin Endocrinol. 2018;doi:10.1111/cen.13842.
A higher endogenous melatonin level in older Japanese men may be associated with decreased risk for developing type 2 diabetes, according to findings…
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Metformin ineffective for long-term metabolic improvements in teen obesity

Lentferink YE, et al. Nutr Diabetes. 2018;doi:10.1038/s41387-018-0057-6.
Adolescents with obesity assigned to long-term metformin therapy experienced initial improvements in BMI and insulin resistance that were not…
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USPSTF endorses behavioral weight-loss intervention, offers less support for medications

September 18, 2018
In an update to its 2012 recommendation, the U.S. Preventive Services Task Force continued to recommend that physicians not only screen for…
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Oral clonidine effectively, safely diagnoses pediatric GH deficiency

Ibba A, et al. Clin Endocrinol. 2018;doi:10.1111/cen.13845.
Among pubertal and prepubertal children with suspected growth hormone deficiency, the adrenergic agonist clonidine can accurately and safely diagnose…
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Early engagement, intervention ‘crucial’ for children diagnosed with type 2 diabetes

Candler TP, et al. Pediatr Diabetes. 2018;doi:10.1111/pedi.12761.
Children newly diagnosed with type 2 diabetes are at high risk for disease-related complications, including a fourfold increase in microalbuminuria…
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Adolescent metabolic health more strongly linked to physical activity than sedentary time

Bell JA, et al. PLoS Med. 2018:doi:10.1371/journal.pmed.1002649.
In adolescents, current physical activity level has a greater effect on metabolic health than time spent being sedentary, according to findings from…
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Suicide, alcohol-related and accidental deaths higher in diabetes

Niskanen L, et al. Eur J Endocrinol. 2018;doi:10.1530/EJE-18-0351.
Finnish adults newly diagnosed with diabetes are more likely to die of suicide, alcohol-related causes or accidents over 7 years vs. those without…
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Obesity, weight change may predict trajectory of childhood sleep-disordered breathing

Frye SS, et al. Ped Obes. 2018;doi:10.1111/ijpo.12461.
Children with obesity and sleep-disordered breathing are more likely to have persistent sleep conditions into adolescence vs. children without…
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Terminology matters in medical communication about obesity

Pearl RL, et al. JAMA Surg. 2018;doi:10.1001/jamasurg.2018.2702.
People with obesity view language such as “obese person” as stigmatizing and prefer that health care providers use people-first language…
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Prenatal exposure to air pollution may influence newborn thyroid function

Howe CG, et al. JAMA Netw Open. 2018;doi:10.1001/jamanetworkopen.2018.2172.
Exposure to high levels of air pollution in pregnancy may have subtle influences on the development of the fetal thyroid gland and its subsequent…
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Discrimination may contribute to obesity among US Latinos

Molina KM, et al. Obesity. 2018;doi:10.1002/oby.22248.
Experience of routine discrimination on adult Latinos may lead to increased BMI and contribute to growing obesity rates, according to study results…
In the Journals PlusPerspective

Recommended upper limits for vitamin D, calcium associated with hypercalciuria

Aloia JF, et al. Clin Endocrinol. 2018;doi:10.1111/cen.13848.
The upper-limit intake for vitamin D recommended by the Endocrine Society, when coadministered with calcium intake at the upper recommended level, is…
In the Journals Plus

Serum estradiol associated with fracture risk in men

Nethander M, et al. J Clin Endocrinol Metab. 2018;doi:10.1210/jc.2018-00934.
Among white men, serum estradiol exerts a “robust causal effect” on fracture risk, independent of age, BMI, smoking status and physical…
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