A 40% increased risk for acute coronary syndromes was found in women with diabetes vs. men with diabetes, according to research presented at the 51st European Association for the Study of Diabetes Annual Meeting.
The researchers conducted a systematic review and meta-analysis of 19 studies that included nearly 11 million patients to determine the RR for acute coronary syndrome (ACS) among men and women with diabetes.
All of the studies were published between 1966 and 2014, and they were included if they reported sex-specific estimates of RR, HR or OR for the link between diabetes and ACS. Sex-specific RR and ratio between women and men were pooled using a random-effects model.
Overall, there were at least 106,703 fatal and nonfatal ACS events.
Compared with men (RR = 1.68; 95% CI, 1.39-2.04), the pooled maximum adjusted RR for ACS associated with diabetes was higher among women (RR = 2.46; 95% CI, 1.92-3.17). When comparing patients with diabetes and those without diabetes, women had a significantly greater risk for ACS (pooled women-to-men RR ratio = 1.38; 95% CI, 1.25-1.52).
“We should avoid sexual prejudice in cardiovascular disease, take all necessary steps to diagnose it early, and control risk factors comprehensively to guarantee the most suitable treatments and best possible outcomes in female patients,” the researchers wrote. – by Amber Cox
Dong X, et al. Poster #269. Presented at: 51st EASD Annual Meeting; Sept. 14-18, 2015; Stockholm.
The researchers report no relevant financial disclosures.