In the JournalsPerspective

Diabetes teams provide timelier, more effective inpatient care with early intervention model

Kyi M, et al. Diabetes Care. 2019;doi:10.2337/dc18-2342.

April 11, 2019

Electronically identifying hospitalized patients with diabetes or new hyperglycemia and allowing a diabetes team to provide immediate expert care without a referral can improve glycemic measures and protect against adverse events, according to findings published in Diabetes Care.

Spiros Fourlanos

“The implications of this trial may be significant for revising approaches to models of care for managing diabetes in hospitals worldwide,” Spiros Fourlanos, MD, PHD, director of the department of diabetes and endocrinology at the The Royal Melbourne Hospital in Australia, told Endocrine Today. “Potentially, diabetes models of care in hospital might need to shift towards delivering more proactive care early in the admission course for people with diabetes.”

Using data from the Randomized Study of a Proactive Inpatient Diabetes Services (RAPIDS), Fourlanos and colleagues evaluated a treatment strategy designed around electronic blood glucose monitoring and compared it with usual care during 24 weeks at Royal Melbourne Hospital. After receiving information from electronic blood glucose meters signaling dysglycemia, a diabetes specialist did not require a referral to begin treatment and could initiate within 24 hours. Usual care required a referral based on medical charts before a specialist could intervene.

The researchers randomly assigned eight wards from the hospital to the intervention or to usual care. Before initiation of the intervention, all wards provided usual care and were observed for 10 weeks as a baseline. Each ward was then observed for 14 weeks once the intervention began. This period was categorized as “active” by the researchers.

From March to August 2016, 1,002 adults were consecutively admitted to the hospital wards. At baseline, 221 were treated in wards assigned to usual care (mean age, 70 years; 38.9% women), and 270 were treated in wards assigned to the intervention (mean age, 70 years; 38.5% women). During the active study period, 220 patients were treated in wards assigned to usual care (mean age, 70 years; 49% women) and 291 were treated in wards assigned to the intervention (mean age, 71 years; 46.4% women).

More patients were treated by a specialist diabetes team in the active intervention group compared with baseline (92% vs. 8%; P < .001); 64% of patients in the intervention group during the active period were treated by a specialist in less than 24 hours compared with only 4% at baseline (P < .001). A higher rate of patients without prior insulin treatment received insulin during active intervention compared with baseline (57% vs. 34%; P < .001).

Intervention led to a greater decrease in number of days with adverse glycemic levels (186 per 1,000 patient-days), based on a “liberal glycemic target” of between 4 mmol/L and 15 mmol/L, compared with usual care in the intervention group at baseline (243 per 1,000 patient-days; P < .001). Patients in the intervention group experienced adverse glycemic days 23% less often than those receiving usual care (P = .008).

The intervention group had a 0.4-mmol/L reduction in mean glucose compared with baseline (P = .003) and a 3.3% rate for days in which blood glucose averaged more than 15 mmol/L compared with 7.3% before intervention (P < .001). The usual care group did not have significantly different results from baseline in either measure. Additionally, a lower risk for hospital-acquired infections was observed in the intervention group compared with the usual care group (adjusted OR = 0.2; 95% CI, 0.07-0.58).

“This research is important as it suggests proactive models of diabetes care in hospital improves the safety of glucose management and could decrease the serious complication of hospital-acquired infection,” Fourlanos said. “We did not expect proactive care to have such a major impact on decreasing hospital-acquired infection. Of course infection was a secondary outcome measure, and ideally these findings need to be validated in future randomized clinical trials.” – by Phil Neuffer

Disclosures: The authors report no relevant financial disclosures.

Electronically identifying hospitalized patients with diabetes or new hyperglycemia and allowing a diabetes team to provide immediate expert care without a referral can improve glycemic measures and protect against adverse events, according to findings published in Diabetes Care.

Spiros Fourlanos

“The implications of this trial may be significant for revising approaches to models of care for managing diabetes in hospitals worldwide,” Spiros Fourlanos, MD, PHD, director of the department of diabetes and endocrinology at the The Royal Melbourne Hospital in Australia, told Endocrine Today. “Potentially, diabetes models of care in hospital might need to shift towards delivering more proactive care early in the admission course for people with diabetes.”

Using data from the Randomized Study of a Proactive Inpatient Diabetes Services (RAPIDS), Fourlanos and colleagues evaluated a treatment strategy designed around electronic blood glucose monitoring and compared it with usual care during 24 weeks at Royal Melbourne Hospital. After receiving information from electronic blood glucose meters signaling dysglycemia, a diabetes specialist did not require a referral to begin treatment and could initiate within 24 hours. Usual care required a referral based on medical charts before a specialist could intervene.

The researchers randomly assigned eight wards from the hospital to the intervention or to usual care. Before initiation of the intervention, all wards provided usual care and were observed for 10 weeks as a baseline. Each ward was then observed for 14 weeks once the intervention began. This period was categorized as “active” by the researchers.

From March to August 2016, 1,002 adults were consecutively admitted to the hospital wards. At baseline, 221 were treated in wards assigned to usual care (mean age, 70 years; 38.9% women), and 270 were treated in wards assigned to the intervention (mean age, 70 years; 38.5% women). During the active study period, 220 patients were treated in wards assigned to usual care (mean age, 70 years; 49% women) and 291 were treated in wards assigned to the intervention (mean age, 71 years; 46.4% women).

More patients were treated by a specialist diabetes team in the active intervention group compared with baseline (92% vs. 8%; P < .001); 64% of patients in the intervention group during the active period were treated by a specialist in less than 24 hours compared with only 4% at baseline (P < .001). A higher rate of patients without prior insulin treatment received insulin during active intervention compared with baseline (57% vs. 34%; P < .001).

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Intervention led to a greater decrease in number of days with adverse glycemic levels (186 per 1,000 patient-days), based on a “liberal glycemic target” of between 4 mmol/L and 15 mmol/L, compared with usual care in the intervention group at baseline (243 per 1,000 patient-days; P < .001). Patients in the intervention group experienced adverse glycemic days 23% less often than those receiving usual care (P = .008).

The intervention group had a 0.4-mmol/L reduction in mean glucose compared with baseline (P = .003) and a 3.3% rate for days in which blood glucose averaged more than 15 mmol/L compared with 7.3% before intervention (P < .001). The usual care group did not have significantly different results from baseline in either measure. Additionally, a lower risk for hospital-acquired infections was observed in the intervention group compared with the usual care group (adjusted OR = 0.2; 95% CI, 0.07-0.58).

“This research is important as it suggests proactive models of diabetes care in hospital improves the safety of glucose management and could decrease the serious complication of hospital-acquired infection,” Fourlanos said. “We did not expect proactive care to have such a major impact on decreasing hospital-acquired infection. Of course infection was a secondary outcome measure, and ideally these findings need to be validated in future randomized clinical trials.” – by Phil Neuffer

Disclosures: The authors report no relevant financial disclosures.

    Perspective
    Nestoras Mathioudakis

    Nestoras Mathioudakis

    Hyperglycemia is highly prevalent among non-critically ill hospitalized patients, and there are multiple challenges to achieving safe and effective glycemic control in the inpatient setting.  In this persuasive study by Kyi and colleagues, the investigators sought to test the hypothesis that clinical inertia by primary inpatient teams in consulting inpatient diabetes specialists contributes to less-effective glycemic control in the hospital.  Using a parallel cluster randomized design in eight medical/surgical units, the study compared usual care (inpatient diabetes consultations requested by primary admitting team) vs. early identification (within first 24 hours) and reflex management by a specialized diabetes team for all inpatients with hyperglycemia. 

    The authors found that early detection and management of hyperglycemia by a diabetes management team resulted in a 24% reduction in adverse glycemic days, defined as a blood glucose less than 4 mmol/L (<72 mg/dl) or >15 mmol/l (>270 mg/dl) and greater use of insulin initiation in previously naïve patients (57% vs. 34%,  P = 0.001) compared to usual care.  While early intervention reduced overt hyperglycemia by 55%, hypoglycemia rates were not significantly reduced. 

    Since multiple observational studies have linked hyperglycemia to poorer clinical outcomes, the study also evaluated the effect of the intervention on secondary outcomes of hospital-acquired infections, acute kidney injury, acute myocardial infarction, unplanned critical care admission and in-hospital mortality.  Over the course of this 24-week trial, there was an 80% reduction in the odds of hospital-acquired infections, but no difference in the other secondary clinical outcomes.

    This is an important study because it is the first randomized controlled trial to demonstrate that early detection and intervention in hyperglycemic inpatients is effective at improving glycemic control and suggests that diabetes specialists are underutilized in the hospital.  Rushakoff and colleagues used a similar approach to detect patients with extreme hyperglycemia via the electronic medical record and delivered an electronic consultation service, and in an observational study was found to be highly effective at reducing rates of both hyperglycemia and hypoglycemia (Rushakoff RJ, et al. Ann Intern Med. 2017;doi: 10.7326/M16-1413). Moreover, the study adds to evidence supporting the role of glycemic control to prevent hospital-acquired infections.

    While the results of this innovative clinical care model were promising, there are several important points to note regarding the generalizability of the study findings.  First, this Australian-based study did not follow the U.S. practice of routinely discontinuing non-insulin antihyperglycemic medications at admission for the majority of hospitalized patients.  Second, the outcomes were limited to the first 14 days of admission, although this would not be expected to have significant impact on inferences drawn since only a very small minority of inpatients have a length of stay longer than this.  Third, although glucose data were available electronically, the hospital in which this study was performed did not have an EMR and structured insulin/glucose order sets, which may have affected the quality of diabetes care provided in the usual care arm.  At our institution, for example, a subcutaneous insulin decision-support tool is available for providers to assist them in selection of an initial insulin regimen (Mathioudakis N, et al. J Diabetes Sci Technol. 2018;doi: 10.1177/1932296818798036).

    Fourth, there were some differences in the intervention group compared to control group (fewer males, lower baseline HbA1c, less insulin use at baseline, more emergent and surgical admissions).  While these differences are likely due to chance alone, a strength of this study was the inclusion of baseline and active periods in both intervention and control arms, which can account for secular trends in hospital care that are not directly related to the intervention itself.

    The authors acknowledge that it could be practically challenging to carry out this type of resource-intensive intervention in a real-world setting, and a cost-effectiveness analysis would be needed to better understand whether the incremental increase in resources (eg, number of diabetes specialists need for higher volume of consultations) is offset by savings (eg, reducing hospital-acquired infections).

    • Nestoras Mathioudakis, MD, MHS
    • Assistant Professor of Medicine
      Clinical Director, Endocrinology, Diabetes, & Metabolism
      Johns Hopkins University School of Medicine

    Disclosures: Mathioudakis reports no relevant financial disclosures.